Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity.

Autor: Zhang T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yu W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Cheng X; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yeung J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA., Ahumada V; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Norris PC; Sciex Demo Lab, Framingham, MA, USA., Pearson MJ; Sciex Demo Lab, Framingham, MA, USA., Yang X; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., van Deursen W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Halcovich C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Nassar A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Vesely MD; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA., Zhang Y; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Zhang JP; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Ji L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Flies DB; NextCure Inc., Beltsville, MD, USA., Liu L; NextCure Inc., Beltsville, MD, USA., Langermann S; NextCure Inc., Beltsville, MD, USA., LaRochelle WJ; Normunity Inc., Boston, MA, USA., Humphrey R; Normunity Inc., Boston, MA, USA., Zhao D; Yale Center for Genome Analysis, Yale University, New Haven, CT, USA., Zhang Q; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Zhang J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gu R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Schalper KA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Sanmamed MF; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Program of Immunology and Immunotherapy, Center for Applied Medical Research, University of Navarra, Pamplona, Spain., Chen L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Publikováno v: Science immunology [Sci Immunol] 2024 Apr 26; Vol. 9 (94), pp. eadh2334. Date of Electronic Publication: 2024 Apr 26.

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