Association of Polymorphism of the Methyl Tetrahydrofolate Reductase (MTHFR) Gene with Anti-Seizure Medication Response in Pediatric Patients in Jeddah, Saudi Arabia

Autor: Reem Alyoubi, Abdullah Althomali, Rania Magadmi, Hala S. Abdel kawy, Hadiah Bassam Al Mahdi, Fatemah O. Kamel, Duaa M. Bakhshwin, Maha Jamal, Mohammed Alsieni

Publikováno v: Medicina, Vol 58, Iss 11, p 1593 (2022)

Background and Objectives: Epilepsy is a chronic brain disease, with inherent and noninherent factors. Although over 20 anti-seizure medications (ASMs) are commercially available, nearly one-third of patients develop drug-resistant epilepsy. We evalu

Externí odkaz: https://doaj.org/article/7b5fe966169f4021a0235f12f368e720

Celecoxib attenuates depressive-like behavior associated with immunological liver injury in C57BL/6 mice through TNF-α and NF-κb dependent mechanisms

Autor: Hala S. Abdel Kawy, Walaa Baher, Mahdy Salama Abou Zeid, Esraa Moustafa ELnahas, Nevien Hendawy

Publikováno v: Life Sciences. 163:23-37

Aim Depression associating patients with chronic liver diseases is a major treatment goal. This study aimed to evaluate the potential hepatoprotective and antidepressant effects of celecoxib in a model of experimental autoimmune hepatitis (EAH) and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b635904af158eb9380b92585459d703
https://doi.org/10.1016/j.lfs.2016.08.027

Theophylline, an old drug with multi-faceted effects: Its potential benefits in immunological liver injury in rats

Autor: Yousria Saad Wahba, Reeham Mohamed Hussein, Amany H Hasanin, Ghada Galal Hamam, Hala S. Abdel Kawy, Osama Mahmod Elsirafy

Publikováno v: Life Sciences. 136:100-107

Aim A low dose of theophylline enhances histone deacetylase activity leading to inhibition of proinflammatory transcription, and inhibits lung fibroblast proliferation. The present work investigated the effect of low dose theophylline on biochemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba581872a6aa1b6e00274fbfccd20d0
https://doi.org/10.1016/j.lfs.2015.06.028

Lamotrigine Decreased Hippocampal Damage and Improved Vascular Risk Markers in a Rat Model of Pentylenetetrazole Induced Kindling Seizure

Autor: Basma S Haggag, Mona H. Raafat, Hala S. Abdel Kawy, Amany H Hasanin

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

Various antiepileptic drugs (AEDs) especially enzyme-inducing AEDs might be associated with increased vascular risk, through impairment of the endogenous antioxidative ability which may trigger oxygen-dependent tissue injury. Lamotrigine (LTG) a non-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888518c4af0d0f7ab2398fb4023ff916
http://europepmc.org/articles/PMC4071181

Cilostazol attenuates cholestatic liver injury and its complications in common bile duct ligated rats

Autor: Hala S. Abdel Kawy

Publikováno v: European journal of pharmacology. 752

Cilostazol is a phosphodiesterase III inhibitor increases adenosine 3′, 5′-cyclic monophosphate (cyclic AMP) level which inhibits hepatic stellate cell activation. Its pharmacological effects include vasodilation, inhibition of vascular smooth mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2edf7b7217812813357b800ebb26d2
https://pubmed.ncbi.nlm.nih.gov/25666386