Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hala Al Adhami"'
Autor:
Hala Al Adhami, Anaïs Flore Bardet, Michael Dumas, Elouan Cleroux, Sylvain Guibert, Patricia Fauque, Hervé Acloque, Michael Weber
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylation have been extensively studied in mouse and human, their conservation in other vertebrat
Externí odkaz:
https://doaj.org/article/abf7797ce69d42e3a33c9d2f9c36fae6
Autor:
Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to ger
Externí odkaz:
https://doaj.org/article/f118f417497a4386a18456d4d7889a0a
Autor:
Thomas Dahlet, Andrea Argüeso Lleida, Hala Al Adhami, Michael Dumas, Ambre Bender, Richard P. Ngondo, Manon Tanguy, Judith Vallet, Ghislain Auclair, Anaïs F. Bardet, Michael Weber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA methyltrasferases play important role during mouse embryo development. Here the authors reveal the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos genome-wide.
Externí odkaz:
https://doaj.org/article/590f66de9a5641b6a92e0860825a1341
Autor:
Jean-Philippe Perrier, Eli Sellem, Audrey Prézelin, Maxime Gasselin, Luc Jouneau, François Piumi, Hala Al Adhami, Michaël Weber, Sébastien Fritz, Didier Boichard, Chrystelle Le Danvic, Laurent Schibler, Hélène Jammes, Hélène Kiefer
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract Background Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation p
Externí odkaz:
https://doaj.org/article/27fba2dd3123471aada1624970fa960c
Autor:
Hala Al Adhami, Judith Vallet, Celia Schaal, Paul Schumacher, Anaïs Flore Bardet, Michael Dumas, Johana Chicher, Philippe Hammann, Sylvain Daujat, Michael Weber
Publikováno v:
Nucleic Acids Research
In mammals, many germline genes are epigenetically repressed to prevent their illegitimate expression in somatic cells. To advance our understanding of the mechanisms restricting the expression of germline genes, we analyzed their chromatin signature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec4dd64b20bdf0997c4bcdaf876072f
https://doi.org/10.1093/nar/gkad071
https://doi.org/10.1093/nar/gkad071
Autor:
Philippe Hammann, Hala Al Adhami, Gonzalo Alvarez, Matthias Truss, Sarah Kottnik, Christian Hagemeier, Johana Chicher, Judith Vallet, Anaïs F. Bardet, Jochen Hecht, Ute Frede, Thomas Dahlet, Michael Weber, Michael Dumas, Uschi Luz, Ghislain Auclair, Peter Hansen, Peter N. Robinson
Publikováno v:
Nature Communications
Nature Communications, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.3582. ⟨10.1038/s41467-021-23596-w⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
In mouse development, long-term silencing by CpG island DNA methylation is specifically targeted to germline genes; however, the molecular mechanisms of this specificity remain unclear. Here, we demonstrate that the transcription factor E2F6, a membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ab6abc4ce0075028f98d18c18beb4e
https://hal.science/hal-03380281/file/Dahlet_NatComm_2021.pdf
https://hal.science/hal-03380281/file/Dahlet_NatComm_2021.pdf
Publikováno v:
Methods in Molecular Biology ISBN: 9781071609576
DNA methylation is extensively reprogrammed during mammalian embryogenesis and germ cell development. Protocols for genome-wide bisulfite sequencing enable the quantification of DNA methylation with high precision and single base-pair resolution; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7eed526dc77d2fdeab0aeeb270cfcf3
https://doi.org/10.1007/978-1-0716-0958-3_14
https://doi.org/10.1007/978-1-0716-0958-3_14
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2214
DNA methylation is extensively reprogrammed during mammalian embryogenesis and germ cell development. Protocols for genome-wide bisulfite sequencing enable the quantification of DNA methylation with high precision and single base-pair resolution; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe22bf7c5dfd16696e05c56240217909
https://pubmed.ncbi.nlm.nih.gov/32944912
https://pubmed.ncbi.nlm.nih.gov/32944912
Autor:
Aurelie Chaulot Talmon, Jean-Philippe Perrier, Valentin Costes, Luc Jouneau, Frambourg Anne, Hala Al Adhami, Hélène Jammes, Hélène Kiefer
Publikováno v:
5. Journée d'Animation Scientifique du réseau épiPhase
5. Journée d'Animation Scientifique du réseau épiPhase, Jun 2019, Toulouse, France. 35 p
HAL
5. Journée d'Animation Scientifique du réseau épiPhase, Jun 2019, Toulouse, France. 35 p
HAL
National audience; La méthylation de l’ADN, est la marque épigénétique la plus étudiée. Plusieurs méthodes pour l’étudier ont été développées, parmi lesquelles le Reduced Representation Bisulfite Sequencing (RRBS), présente certains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4c795439ddfcc830b26d3b872a097547
https://hal.inrae.fr/hal-02734801
https://hal.inrae.fr/hal-02734801
Autor:
Jean-Philippe Perrier, Audrey Prézelin, Maxime Gasselin, Luc Jouneau, Francois PIUMI, Hala Al Adhami, Weber, M., Sebastien Fritz, Didier Boichard, Chrystelle Le Danvic, Laurent Schibler, Hélène Jammes, Hélène Kiefer
Publikováno v:
Advances in Animal Biosciences
International Bull Fertility Conference
International Bull Fertility Conference, British Society of Animal Science (BSAS). GBR., May 2018, Westport, Ireland
HAL
International Bull Fertility Conference
International Bull Fertility Conference, British Society of Animal Science (BSAS). GBR., May 2018, Westport, Ireland
HAL
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::49a9a402885b08781f4c8bc85cce1bd8
https://hal.inrae.fr/hal-02736565
https://hal.inrae.fr/hal-02736565