Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss

Autor: Sheri L. Peterson, Hal X. Nguyen, Oscar A. Mendez, Aileen J. Anderson

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The inflammatory response to spinal cord injury (SCI) involves localization and activation of innate and adaptive immune cells and proteins, including the complement cascade. Complement C3 is important for the classical, alternative, and lec

Externí odkaz: https://doaj.org/article/f77d46d4add041179bd71265ab11ab96

List of Contributors

Autor: Hermann Ackermann, Mauro Adenzato, Diana R. Alkire, Luc H. Arnal, Cesar Ávila, Bruno G. Bara, Brian Barton, Shari R. Baum, Michael S. Beauchamp, Jeffrey R. Binder, Ferdinand Christoph Binkofski, Shane Blau, Sheila E. Blumstein, Tobias Bormann, Ina Bornkessel-Schlesewsky, Francesca M. Branzi, Bettina Brendel, Alyssa A. Brewer, Iris Broce, Timothy T. Brown, Bradley R. Buchsbaum, David Caplan, Svenja Caspers, Tracy M. Centanni, Edward F. Chang, Jennifer Chesters, Derya Çokal, Emily L. Connally, David P. Corina, H. Branch Coslett, Albert Costa, Steven C. Cramer, Suzanne Curtin, Matthew H. Davis, Gary S. Dell, Özlem Ece Demir, Isabelle Deschamps, Anthony Steven Dick, Frederic Dick, Danielle S. Dickson, Hugues Duffau, E. Susan Duncan, Guinevere F. Eden, Crystal T. Engineer, Ivan Enrici, Julia L. Evans, Tanya M. Evans, Luciano Fadiga, Kara D. Federmeier, Fernanda Ferreira, Evelyn C. Ferstl, Julie A. Fiez, Simon E. Fisher, Carol A. Fowler, Julius Fridriksson, Angela D. Friederici, Jackson T. Gandour, Fatemeh Geranmayeh, Morton Ann Gernsbacher, Marta Ghio, Anne-Lise Giraud, Susan Goldin-Meadow, Maria Luisa Gorno-Tempini, Vincent L. Gracco, Elizabeth J. Grace, Deanna J. Greene, Frank H. Guenther, Peter Hagoort, Uri Hasson, Olaf Hauk, Shannon Heald, Arturo E. Hernandez, Gregory Hickok, Argye E. Hillis, Lori L. Holt, Norbert Hornstein, John F. Houde, William J. Idsardi, Cassandra L. Jacobs, Ned Jenkinson, Ingrid S. Johnsrude, Michael P. Kilgard, Tilo Kircher, Juliane Klann, Serena Klos, Sonja A. Kotz, Anthony J. Krafnick, Ananthanarayan Krishnan, Saloni Krishnan, Dorothee Kuemmerer, Marta Kutas, Robert Leech, Matthew K. Leonard, Christina N. Lessov-Schlaggar, Susan C. Levine, Daniel A. Llano, Andrew J. Lotto, Alec Marantz, Conor T. McLennan, Lars Meyer, Lee M. Miller, Bettina Mohr, Philip J. Monahan, Emily M. Morson, Mariachristina Musso, Srikantan S. Nagarajan, Arne Nagels, Hal X. Nguyen, Nazbanou Nozari, Howard Nusbaum, Olumide A. Olulade, Karalyn Patterson, Silke Paulmann, Michael Petrides, David B. Pisoni, David Poeppel, Peter Pressman, Friedemann Pulvermüller, Liina Pylkkänen, Anjali Raja Beharelle, Matthew A. Lambon Ralph, Kathleen Rastle, Josef P. Rauschecker, Jessica D. Richardson, Michel Rijntjes, Giacomo Rizzolatti, Jennifer M. Rodd, Corianne Rogalsky, Stefano Rozzi, Ayşe Pinar Saygin, Bradley L. Schlaggar, Gottfried Schlaug, Matthias Schlesewsky, Myrna F. Schwartz, Michael Schwartze, Sophie K. Scott, Steven L. Small, Kimberly Smith, Jon Sprouse, Anja Staiger, Craig E.L. Stark, Shauna M. Stark, Adrian Staub, Edward Taub, Marco Tettamanti, Sharon L. Thompson-Schill, Donna C. Tippett, Pascale Tremblay, Peter Turkeltaub, Michael T. Ullman, Kate E. Watkins, Cornelius Weiller, Richard J.S. Wise, Jeffrey M. Zacks, Wolfram Ziegler

Publikováno v: Neurobiology of Language (2018)

Externí odkaz: https://doaj.org/article/ec1e2e115796496983673391432ce6ac

Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair

Autor: Nobuko Uchida, Jake Maddox, Aileen J. Anderson, Desirée L. Salazar, Rebecca A. Nishi, Arjang Salehi, Mitra J. Hooshmand, Anita Lakatos, Hal X. Nguyen, Hirokazu Saiwai

Publikováno v: Nguyen, Hal X; Hooshmand, Mitra J; Saiwai, Hirokazu; Maddox, Jake; Salehi, Arjang; Lakatos, Anita; et al.(2017). Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(38), 9269-9287. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/8fp0g596

The interaction of transplanted stem cells with local cellular and molecular cues in the host CNS microenvironment may affect the potential for repair by therapeutic cell populations. In this regard, spinal cord injury (SCI), Alzheimer's disease, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5662ea41972e75d647c0f5399beb3dca
https://doi.org/10.1523/jneurosci.2785-16.2017

Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis

Autor: Francisca Benavente, Brian J. Cummings, Mitra J. Hooshmand, Lisa A. Flanagan, Nobuko Uchida, Samuel Hong, Katja M. Piltti, Aileen J. Anderson, Hal X. Nguyen

Publikováno v: Hooshmand, MJ; Nguyen, HX; Piltti, KM; Benavente, F; Hong, S; Flanagan, L; et al.(2017). Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis. JOURNAL OF IMMUNOLOGY, 199(3), 1069-1085. doi: 10.4049/jimmunol.1600064. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1k1261kb

Inflammatory processes play a key role in pathophysiology of many neurologic diseases/trauma, but the effect of immune cells and factors on neurotransplantation strategies remains unclear. We hypothesized that cellular and humoral components of innat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63a8bd2ff211e51959dd2b570026509
https://europepmc.org/articles/PMC5523578/

Induction of early neural precursors and derivation of tripotent neural stem cells from human pluripotent stem cells under xeno-free conditions

Autor: Gabrielle Funes, Usha Nekanti, Daniel L. Haus, Noriko Kamei, Denisse Moreno, Brian J. Cummings, Hal X. Nguyen, Aileen J. Anderson

Publikováno v: Journal of Comparative Neurology. 522:2767-2783

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) can differentiate into many cell types and are important for regenerative medicine; however, further work is needed to reliably differentiate hESC and hiPSC into neural-rest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c4fcbbdb1399cc917fd5ecdd1ab9834
https://doi.org/10.1002/cne.23604