Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Hal S Alper"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Plastic waste is an environmental challenge, but also presents a biotechnological opportunity as a unique carbon substrate. With modern biotechnological tools, it is possible to enable both recycling and upcycling. To realize a plastics bioe
Externí odkaz:
https://doaj.org/article/dd6c618cf7e44a00b7fd62a1cf4a8aea
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 2, Pp 330-339 (2024)
Metabolic engineering and synthetic biology endeavors benefit from promoters that perform consistently (or robustly) with respect to cellular growth phase (exponential and stationary) and fermentation scale (microtiter plates, tubes, flasks, and bior
Externí odkaz:
https://doaj.org/article/c525f422e5a54c62826bd04b0945da43
Autor:
Kevin B. Reed, Sierra M. Brooks, Jordan Wells, Kristin J. Blake, Minye Zhao, Kira Placido, Simon d’Oelsnitz, Adit Trivedi, Shruti Gadhiyar, Hal S. Alper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Halogen-containing molecules are ubiquitous in modern society and present unique chemical possibilities. As a whole, de novo fermentation and synthetic pathway construction for these molecules remain relatively underexplored and could unlock
Externí odkaz:
https://doaj.org/article/8260c887a6ec49b9968a8f5117e7e310
Autor:
Simon d’Oelsnitz, Daniel J. Diaz, Wantae Kim, Daniel J. Acosta, Tyler L. Dangerfield, Mason W. Schechter, Matthew B. Minus, James R. Howard, Hannah Do, James M. Loy, Hal S. Alper, Y. Jessie Zhang, Andrew D. Ellington
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract A major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is the slow process of biocatalyst engineering. Amaryllidaceae alkaloids, such as the Alzheimer’s medication galantamine, are complex plant secondary m
Externí odkaz:
https://doaj.org/article/a590be639471443d8f68f7c532e9fc11
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36193 (2012)
Establishing causative links between protein functional domains and global gene regulation is critical for advancements in genetics, biotechnology, disease treatment, and systems biology. This task is challenging for multifunctional proteins when rel
Externí odkaz:
https://doaj.org/article/3caec5a606c343ac899c39fbb75971e5
Autor:
Sierra M. Brooks, Celeste Marsan, Kevin B. Reed, Shuo-Fu Yuan, Dustin-Dat Nguyen, Adit Trivedi, Gokce Altin-Yavuzarslan, Nathan Ballinger, Alshakim Nelson, Hal S. Alper
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Plant-derived phenylpropanoids, in particular phenylpropenes, have diverse industrial applications ranging from flavors and fragrances to polymers and pharmaceuticals. Heterologous biosynthesis of these products has the potential to address
Externí odkaz:
https://doaj.org/article/39089d9ee8fe4481a6acd2bae325f8a2
Autor:
Kevin B. Reed, Sierra M. Brooks, Jordan Wells, Kristin J. Blake, Minye Zhao, Kira Placido, Simon d’Oelsnitz, Adit Trivedi, Shruti Gadhiyar, Hal S. Alper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/548beea9f3c0492c83bc522647b3c8ab
Autor:
Widianti Sugianto, Gokce Altin-Yavuzarslan, Benjamin I. Tickman, Cholpisit Kiattisewee, Shuo-Fu Yuan, Sierra M. Brooks, Jitkanya Wong, Hal S. Alper, Alshakim Nelson, James M. Carothers
Publikováno v:
Materials Today Bio, Vol 20, Iss , Pp 100677- (2023)
Engineered living materials (ELMs) fabricated by encapsulating microbes in hydrogels have great potential as bioreactors for sustained bioproduction. While long-term metabolic activity has been demonstrated in these systems, the capacity and dynamics
Externí odkaz:
https://doaj.org/article/c4f2185457494e1da21c785cea4cb26d
Autor:
Linfeng Xu, Kai-Chun Chang, Emory M. Payne, Cyrus Modavi, Leqian Liu, Claire M. Palmer, Nannan Tao, Hal S. Alper, Robert T. Kennedy, Dale S. Cornett, Adam R. Abate
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
The testing of engineered enzymes represents a bottleneck. Here the authors report a screening method combining microfluidics and mass spectrometry, to map the catalysis of a mutated enzyme, characterise the range of products generated and recover th
Externí odkaz:
https://doaj.org/article/6fe5bdb2b28d44e59283b3db5ce5e415
Autor:
Shuo-Fu Yuan, Sierra M. Brooks, Annalee W. Nguyen, Wen-Ling Lin, Trevor G. Johnston, Jennifer A. Maynard, Alshakim Nelson, Hal S. Alper
Publikováno v:
Bioactive Materials, Vol 6, Iss 8, Pp 2390-2399 (2021)
Traditional production of industrial and therapeutic proteins by eukaryotic cells typically requires large-scale fermentation capacity. As a result, these systems are not easily portable or reusable for on-demand protein production applications. In t
Externí odkaz:
https://doaj.org/article/d26f053a7ee64bfaae524d28830bac26