Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Hal M, Hoffman"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 481-497 (2024)
Background & Aims: Breast regression protein 39 (BRP39) (Chi3L1) and its human homolog YKL-40, is an established biomarker of liver fibrosis in nonalcoholic steatohepatitis (NASH) patients, but its role in NASH pathogenesis remains unclear. We recent
Externí odkaz:
https://doaj.org/article/0912e3a866a448f6a829e475f32d388a
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The NLRP3 inflammasome is an intracellular, multiprotein complex that promotes the auto-catalytic activation of caspase-1 and the subsequent maturation and secretion of the pro-inflammatory cytokines, IL-1β and IL-18. Persistent activation
Externí odkaz:
https://doaj.org/article/a9366cea20b64379ae3b798f5d428a2d
Autor:
Angela Cabral, Julia Elise Cabral, Angelina Wang, Yiyang Zhang, Hailin Liang, Donya Nikbakht, Leslie Corona, Hal M. Hoffman, Reginald McNulty
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome. Here, we show that
Externí odkaz:
https://doaj.org/article/106b9a8d8d3343f1bc27a0247de447fa
Autor:
Christian Stoess, Yeon-Kyung Choi, Janset Onyuru, Helmut Friess, Hal M. Hoffman, Daniel Hartmann, Ariel E. Feldstein
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 559 (2024)
Cell death is crucial for maintaining tissue balance and responding to diseases. However, under pathological conditions, the surge in dying cells results in an overwhelming presence of cell debris and the release of danger signals. In the liver, this
Externí odkaz:
https://doaj.org/article/9a038d8743d54482831945e945d0ad48
Autor:
Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Griffin, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, José M. González-Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hoffman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz, Samuel Bertin
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-24 (2023)
Abstract Background Individuals with certain chronic inflammatory lung diseases have a higher risk of developing lung cancer (LC). However, the underlying mechanisms remain largely unknown. Here, we hypothesized that chronic exposure to house dust mi
Externí odkaz:
https://doaj.org/article/f506227a08414d8eb5c6d5a982b91b04
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71601d03ca0a42d8941718d51407d3e9
Autor:
Jihoon Kim, Chisato Shimizu, Ming He, Hao Wang, Hal M. Hoffman, Adriana H. Tremoulet, John Y.-J. Shyy, Jane C. Burns
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12318 (2023)
Although Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) share some clinical manifestations, their cardiovascular outcomes are different, and this may be reflected at the level of the endothelial cell (EC). We performe
Externí odkaz:
https://doaj.org/article/59bde23141e1439b915b2a0abeba0faf
Autor:
Wai W. Cheung, Sheng Hao, Ronghao Zheng, Zhen Wang, Alex Gonzalez, Ping Zhou, Hal M. Hoffman, Robert H. Mak
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 5, Pp 1296-1311 (2021)
Abstract Background Ctns−/− mice, a mouse model of infantile nephropathic cystinosis, exhibit hypermetabolism with adipose tissue browning and profound muscle wasting. Inflammatory cytokines such as interleukin (IL)‐1 trigger inflammatory casca
Externí odkaz:
https://doaj.org/article/65d366eed65f485ebf1f43f6c6b27094
Autor:
Angela Cabral, Julia Elise Cabral, Angelina Wang, Yiyang Zhang, Hailin Liang, Donya Nikbakht, Leslie Corona, Hal M. Hoffman, Reginald McNulty
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5bfb3f5e0d0c4ef995b0f133540db61a
Autor:
Wai W. Cheung, Ronghao Zheng, Sheng Hao, Zhen Wang, Alex Gonzalez, Ping Zhou, Hal M. Hoffman, Robert H. Mak
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis
Externí odkaz:
https://doaj.org/article/e4b1d33e01524a95bb59afcecfed6c92