Výsledky vyhledávání - "Hakuo Ikegami"

Role of p53 in the inhibitory effects of interferon-α subtypes on proliferation of hepatocellular carcinoma cells

Autor: Norie Arai, Harumi Ariyasu, Shigeto Yamamoto, Tsunetaka Ohta, Masao Ikeda, Tadao Tanimoto, Masashi Kurimoto, Toshio Ariyasu, Shigeharu Fukuda, Hakuo Ikegami, Noboru Fujioka

Publikováno v: Biomedical Research. 27:219-226

While interferon-alpha (IFN-alpha) subtypes share a common specific receptor composed of two subunits, interferon-alpha receptor (IFNAR)-1 and IFNAR-2, their subtype activities are exhibited via several intracellular signaling pathways and thus subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fb34639c6b537af690d5ace718d052
https://doi.org/10.2220/biomedres.27.219

Zobrazit plný text záznamu

In vitro effects of interferon-alpha subtypes on the Th1/Th2 balance in the peripheral blood mononuclear cells from patients with hepatitis C virus infection

Autor: Takeshi Tanaka, Masashi Kurimoto, Masao Ikeda, Hakuo Ikegami, Hiroshi Yamauchi, Yoshiaki Yanai, Shigeto Yamamoto, Noboru Fujioka, Toshio Ariyasu, Kunzo Orita

Publikováno v: Biomedical Research. 25:75-82

Enhanced T helper 1 (Th1)-type immunity was observed in patients with hepatitis C virus (HCV) infection during investigations on the efficiency of interferon (IFN) therapy. The mechanism for the shift to Th1-type immunity is, however, obscure in HCV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22d8eef58478d4e806e59bc4dbf833f2
https://doi.org/10.2220/biomedres.25.75

Zobrazit plný text záznamu

In vitro Modification of Th1/Th2 Balance by Interferon-alpha Subtypes in Peripheral Blood Mononuclear Cells from Patients with Hepatitis B Virusinfection

Autor: Toshio Ariyasu, Noboru Fujioka, Hakuo Ikegami, Hiroshi Yamauchi, Masashi Kurimoto, Shigeto Yamamoto, Takeshi Tanaka, Yoshiaki Yanai, Masao Ikeda

Publikováno v: Biomedical Research. 24:231-237

T helper (Th) cells have been characterized into two subsets, Th1 and Th2, by the pattern of cytokine secretion. Generally, Th1 type cells mediate cellular immune responses and Th2 type cells mediate humoral immunity. Recently, Thl type immunity is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f0d7ba7e936ab159d81814f3b42327c
https://doi.org/10.2220/biomedres.24.231

Zobrazit plný text záznamu

The anti-tumor activities of interferon (IFN)-α in chronic myelogenous leukaemia (CML)-derived cell lines depends on the IFN-α subtypes

Autor: Osamu Sanou, Kouzou Yamamoto, Masashi Kurimoto, Yoshiaki Yanai, Hiroshi Yamauchi, Hakuo Ikegami

Publikováno v: Cancer Letters. 185:173-179

Here we report on the anti-tumor effects of five interferon (IFN)-alpha subtypes, alpha1, alpha2, alpha5, alpha8, and alpha10 in chronic myelogenous leukaemia (CML)-derived cell lines. All of the CML cells can respond to IFN-alpha although the anti-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f488feb107890debae71972462e1297e
https://doi.org/10.1016/s0304-3835(02)00277-x

Zobrazit plný text záznamu

Different antiviral activities of IFN-α subtypes in human liver cell lines: synergism between IFN-α2 and IFN-α8

Autor: Osamu Sanou, Masashi Kurimoto, Hakuo Ikegami, Shigeto Yamamoto, Hirohisa Yano, Masamichi Kojiro

Publikováno v: Hepatology Research. 24:99-106

We have studied the antiviral activities of five recombinant interferon-alpha (IFN-alpha) subtypes, namely IFN-alpha1, -alpha2, -alpha5, -alpha8 and -alpha10, in eight human liver cancer cell lines. The relative antiviral activities, expressed in ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d3d24f48d6b22e8d5c0f06cbf66e75
https://doi.org/10.1016/s1386-6346(02)00020-7

Zobrazit plný text záznamu

Characterization of the Antitumor Activities of IFN-α8 on Renal Cell Carcinoma CellsIn Vitro

Autor: Kouzou Yamamoto, Tadaichi Kitamura, Hakuo Ikegami, Hiroshi Yamauchi, Masashi Kurimoto, Shigeo Horie, Yoshiaki Yanai

Publikováno v: Journal of Interferon & Cytokine Research. 21:1129-1136

Interferon-alpha (IFN-alpha) has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin. IFN-alpha includes several subtypes, and little has been reported on the biologic properties of the individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1366b65510317a81db3a203ea6994999
https://doi.org/10.1089/107999001317205268

Zobrazit plný text záznamu

Intracellular production of interleukin-18 in human epithelial-like cell lines is enhanced by hyperosmotic stress in vitro

Autor: Masashi Kurimoto, Kenji Akita, Tetsuya Mori, Makoto Takeuchi, Hakuo Ikegami, Masao Ikeda, Takanori Okura, Tsunetaka Ohta

Publikováno v: Cell and Tissue Research. 297:467-473

Interleukin-18 is a novel multifunctional cytokine, which enhances natural killer cell activity and promotes the induction of cytokine production, including that of interferon-gamma by T cells and antitumor effects. Interleukin-18 is produced by cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6661654e5c588b9f90146b6a3fcdd2
https://doi.org/10.1007/s004410051373

Zobrazit plný text záznamu

Interleukin-18 Induces Interferon-γ Production through NF-κB and NFAT Activation in Murine T Helper Type 1 Cells

Autor: Yasushi Aizawa, Masashi Kurimoto, Kazue Tsuji-Takayama, Iwao Okamoto, Tsunetaka Ohta, Kazuhiro Koide, Hirotada Kojima, Hakuo Ikegami, Makoto Takeuchi

Publikováno v: Cellular Immunology. 196:41-50

Interleukin-18 (IL-18) combined with anti-CD3 monoclonal antibody (mAb) induced interferon-gamma (IFN-gamma) production by T helper type 1 (Th1) cells. Neither IL-18 nor anti-CD3 mAb alone induced production of IFN-gamma. Although treatment with IL-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53b275fb08279920a25f6b5b4e52581
https://doi.org/10.1006/cimm.1999.1542

Zobrazit plný text záznamu

An Essential Role for NF-κB in IL-18-Induced IFN-γ Expression in KG-1 Cells

Autor: Hirotada Kojima, Yasushi Aizawa, Yoshiaki Yanai, Katsue Nagaoka, Makoto Takeuchi, Tsunetaka Ohta, Hakuo Ikegami, Masao Ikeda, Masashi Kurimoto

Publikováno v: The Journal of Immunology. 162:5063-5069

IL-18 is a multifunctional cytokine playing various regulatory roles in the immune system including induced cytokine production. As a part of our ongoing studies on the molecular mechanisms of IL-18-induced IFN-γ production, we have examined the tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2b6668e7974154252b30bc49a080087
https://doi.org/10.4049/jimmunol.162.9.5063

Zobrazit plný text záznamu

Simultaneous exposure to interleukin-18 and interleukin-10 in vitro synergistically augments murine spleen natural killer cell activity

Autor: Kakuji Torigoe, Masashi Kurimoto, Mark Micallef, Tadao Tanimoto, Yoshihiro Nishida, Hakuo Ikegami, Keizo Kohno

Publikováno v: Cancer Immunology, Immunotherapy. 48:109-117

Interleukin-18 (IL-18) enhances interferon gamma (IFNgamma) production and natural killer (NK) cell activity, and elicits protective antitumor effects in vivo. IL-18 and IL-12 synergistically augment IFNgamma production reportedly because IL-12 enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4700839ac9b4e9234707b68ebcc074
https://doi.org/10.1007/s002620050554

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání