Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hakkola, J. (Jukka)"'
Autor:
Nabil, H. (Heba), Kummu, O. (Outi), Lehenkari, P. (Petri), Rysä, J. (Jaana), Risteli, J. (Juha), Hakkola, J. (Jukka), Hukkanen, J. (Janne)
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor that regulates drug metabolism in the liver and intestine. In our clinical trials on healthy volunteers to discover novel metabolic functions of PXR activation, we observed that rifam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::9b4d64b69544a1861eade1b548ac881f
http://urn.fi/urn:nbn:fi-fe202201122012
http://urn.fi/urn:nbn:fi-fe202201122012
Autor:
Küblbeck, J. (Jenni), Vuorio, T. (Taina), Niskanen, J. (Jonna), Fortino, V. (Vittorio), Braeuning, A. (Albert), Abass, K. (Khaled), Rautio, A. (Arja), Hakkola, J. (Jukka), Honkakoski, P. (Paavo), Levonen, A.-L. (Anna-Liisa)
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::2673943252514961cf08ce20d71a6a8c
http://urn.fi/urn:nbn:fi-fe2020070646963
http://urn.fi/urn:nbn:fi-fe2020070646963
Pregnane X receptor activator rifampin increases blood pressure and stimulates plasma renin activity
Autor:
Hassani‐Nezhad‐Gashti, F. (Fatemeh), Salonurmi, T. (Tuire), Hautajärvi, H. (Heidi), Rysä, J. (Jaana), Hakkola, J. (Jukka), Hukkanen, J. (Janne)
We conducted a clinical trial with 22 healthy volunteers to investigate the effects of pregnane X receptor (PXR) agonist rifampin on blood pressure (BP). The study was randomized, crossover, single‐blind, and placebo‐controlled. Rifampin 600 mg o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::6b325f1cddbf413678cecda99c1a733f
http://urn.fi/urn:nbn:fi-fe2020112592982
http://urn.fi/urn:nbn:fi-fe2020112592982
On the basis of official Finnish Medicines Authority (Fimea)-approved drug monographs, less than half of the approved small-molecule drugs between 2007 and 2016 were substrates, inhibitors or inducers of CYP enzymes, predominantly of CYP3A4. No signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::9ec6c13320b385fb0f8ae2343aefb468
http://urn.fi/urn:nbn:fi-fe2020113098699
http://urn.fi/urn:nbn:fi-fe2020113098699
Autor:
Hakkola, J. (Jukka), Bernasconi, C. (Camilla), Coecke, S. (Sandra), Richert, L. (Lysiane), Andersson, T. B. (Tommy B.), Pelkonen, O. (Olavi)
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and peroxisome proliferator‐activated receptor α (PPARα) are ligand‐activated transcription factors that regulate expression of many xenobiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::f26da587c978450876fc6fd147f2ac08
http://urn.fi/urn:nbn:fi-fe201901111962
http://urn.fi/urn:nbn:fi-fe201901111962
Significance: Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms. They play an important role in the adjustment of metabolic pathways in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::48c794b9f66a2cbe1a2ff652e3d0cd89
http://urn.fi/urn:nbn:fi-fe2019070222525
http://urn.fi/urn:nbn:fi-fe2019070222525
The pregnane X receptor (PXR), a xenobiotic-sensing nuclear receptor, is a key regulator of drug and xenobiotic metabolism. Additionally, PXR regulates hepatic glucose, lipid, cholesterol, and bile acid metabolism, and inflammation. However, the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::5376176710a7b47c31c34fba03be47d1
http://urn.fi/urn:isbn:9789526234991
http://urn.fi/urn:isbn:9789526234991
Autor:
Karpale, M. (Mikko)
The prevalence of metabolic diseases is paralleled by increases in exposure to foreign chemicals, e.g. drugs and environmental contaminants. Rather common for these chemicals is their ability to activate Pregnane X receptor (PXR), a master regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::efb15d97fd9c626014a2ea3bace4f366
http://urn.fi/urn:isbn:9789526229980
http://urn.fi/urn:isbn:9789526229980
Vitamin D deficiency, i.e., low circulating 25-hydroxyvitamin D (25(OH)D) level, has been consistently associated with the prevalence of metabolic diseases, including types 1 and 2 diabetes. However, the causal link between low vitamin D and metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::a6474926fb55a2ed0d7d716fbde7731d
http://urn.fi/urn:isbn:9789526226422
http://urn.fi/urn:isbn:9789526226422
Autor:
Aatsinki, S.-M. (Sanna-Mari)
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a master regulator of energy metabolism and mitochondrial biology in high-energy cell types and tissues. The regulation of PGC-1α is versatile, and both transcriptional and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::3f10a9170aa4a8ca27469d0405e8d5a5
http://urn.fi/urn:isbn:9789526208053
http://urn.fi/urn:isbn:9789526208053