Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hakju Kwon"'
Publikováno v:
The Journal of Immunology. 204:220.22-220.22
Within the human immune system, the expression of GPR56, an adhesion G-protein couple receptor, is restricted to cytotoxic Natural Killer (NK) and T lymphocytes, including T effector memory re-expressing CD45RA (TEMRA) cells. In primary NK cells, GPR
Autor:
Warner C. Greene, Bobby Benitez, Louise Ogle, Dean W. Felsher, Mauricio Montano, Hakju Kwon, Jan Bohuslav
Publikováno v:
Journal of Biological Chemistry. 280:35713-35722
Type I human T cell leukemia virus (HTLV-I) is etiologically linked with adult T cell leukemia, an aggressive and usually fatal expansion of activated CD4+ T lymphocytes that frequently traffic to skin. T cell transformation induced by HTLV-I involve
Publikováno v:
Journal of Biological Chemistry. 279:26115-26125
Apoptosis induced by p53 has been proposed to involve activation of the transcription factor NF-kappaB. Here we describe the novel molecular mechanism through which p53 and DNA-damaging agents activate NF-kappaB. NF-kappaB induction by p53 does not o
Publikováno v:
Oncogene. 20:1900-1912
The interferon (IFN)-inducible double stranded (ds) RNA-activated protein kinase PKR plays an important role in protein synthesis by modulating the phosphorylation of the alpha-subunit of eukaryotic initiation fact 2 (eIF-2 alpha). In addition to tra
Publikováno v:
Journal of Clinical Investigation. 107:143-151
Transcriptional regulators of the NF-kB/IkB family promote the expression of well over 100 target genes, the majority of which participate in the host immune response (1). These proteins include a multitude of cytokines and chemokines, receptors requ
Autor:
John Hiscott, Carmela DeLuca, Marc J. Servant, Pierre Génin, Hakju Kwon, Yael Mamane, Christophe Heylbroeck, Rongtuan Lin, Michèle Algarté, Cécile LePage
Publikováno v:
Gene. 237:1-14
Interferons are a large family of multifunctional secreted proteins involved in antiviral defense, cell growth regulation and immune activation. Viral infection induces transcription of multiple IFN genes, a response that is in part mediated by the i
Publikováno v:
Oncogene. 18:495-505
Activation of the NF-kappa-B transcription factors has been shown to be directly influenced by changes in the microtubule cytoskeleton network. To better understand cytoskeletal regulation of NF-kappaB, experiments were performed to determine whether
Publikováno v:
Virology. 244:27-38
HIV-1 infection of primary monocytic cells and myeloid cell lines results in sustained NF-kappaB activation. Recently, NF-kappaB induction has been shown to play a role in protecting cells from programmed cell death. In the present study, we sought t
Autor:
Nadine Pelletier, John Hiscott, Hakju Kwon, Carmela DeLuca, Sonia Cisternas, Mark A. Wainberg, Pierre Génin, Rongtuan Lin
Publikováno v:
Journal of Biological Chemistry. 273:7431-7440
Human immunodeficiency virus (HIV-1) utilizes the NF-kappaB/Rel proteins to regulate transcription through NF-kappaB binding sites in the HIV-1 long terminal repeat (LTR). Normally, NF-kappaB is retained in the cytoplasm by inhibitory IkappaB protein
Autor:
Pierre Beauparlant, Carmela DeLuca, Hakju Kwon, Louisa Petropoulos, Pascale Crépieux, Rongtuan Lin, John Hiscott
Publikováno v:
Journal of Leukocyte Biology. 62:82-92
NF-kappa B/Rel transcription factors participate in the activation of numerous genes involved in immune regulation/inflammation including cytokines, cell surface receptors, adhesion molecules, and acute phase proteins. NF-kappa B activity is controll