Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hakhamanesh Mostafavi"'
Autor:
Hakhamanesh Mostafavi, Arbel Harpak, Ipsita Agarwal, Dalton Conley, Jonathan K Pritchard, Molly Przeworski
Publikováno v:
eLife, Vol 9 (2020)
Fields as diverse as human genetics and sociology are increasingly using polygenic scores based on genome-wide association studies (GWAS) for phenotypic prediction. However, recent work has shown that polygenic scores have limited portability across
Externí odkaz:
https://doaj.org/article/c7060bde0ad34e4baa0888ee9c26f709
Autor:
Jeremy J Berg, Arbel Harpak, Nasa Sinnott-Armstrong, Anja Moltke Joergensen, Hakhamanesh Mostafavi, Yair Field, Evan August Boyle, Xinjun Zhang, Fernando Racimo, Jonathan K Pritchard, Graham Coop
Publikováno v:
eLife, Vol 8 (2019)
Several recent papers have reported strong signals of selection on European polygenic height scores. These analyses used height effect estimates from the GIANT consortium and replication studies. Here, we describe a new analysis based on the the UK B
Externí odkaz:
https://doaj.org/article/ab49c7c9474e42549524c281c71f19e5
Autor:
Hakhamanesh Mostafavi, Tomaz Berisa, Felix R Day, John R B Perry, Molly Przeworski, Joseph K Pickrell
Publikováno v:
PLoS Biology, Vol 15, Iss 9, p e2002458 (2017)
A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness. As a step towards this goal, we developed a method to examine whether individual genetic variants, or sets of g
Externí odkaz:
https://doaj.org/article/1058f9c026d74d709d5d086803e46b72
Publikováno v:
bioRxiv
The Discrete-Time Wright Fisher (DTWF) model and its large population diffusion limit are central to population genetics. These models describe the forward-in-time evolution of the frequency of an allele in a population and can include the fundamenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ef3152fb2df13b272e080d09c171be
https://doi.org/10.1101/2023.05.19.541517
https://doi.org/10.1101/2023.05.19.541517
Publikováno v:
bioRxiv
Measures of selective constraint on genes have been used for many applications including clinical interpretation of rare coding variants, disease gene discovery, and studies of genome evolution. However, widely-used metrics are severely underpowered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa6056fedd4ea44f61000c6339bd4b9
https://europepmc.org/articles/PMC10245655/
https://europepmc.org/articles/PMC10245655/
Autor:
Roshni A. Patel, Shaila A. Musharoff, Jeffrey P. Spence, Harold Pimentel, Catherine Tcheandjieu, Hakhamanesh Mostafavi, Nasa Sinnott-Armstrong, Shoa L. Clarke, Courtney J. Smith, Peter P. Durda, Kent D. Taylor, Russell Tracy, Yongmei Liu, W. Craig Johnson, Francois Aguet, Kristin G. Ardlie, Stacey Gabriel, Josh Smith, Deborah A. Nickerson, Stephen S. Rich, Jerome I. Rotter, Philip S. Tsao, Themistocles L. Assimes, Jonathan K. Pritchard
Publikováno v:
Am J Hum Genet
Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of significant hits. However, at present we lack a principled way of u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35dac39dd4c125263fb7dc4a68abd6e1
https://doi.org/10.1101/2022.10.04.509926
https://doi.org/10.1101/2022.10.04.509926
Autor:
Mark J. Daly, Timothy Poterba, Matthew Aguirre, Matti Pirinen, Carlos Bustamante, Guhan Venkataraman, Chris C. A. Spencer, Hakhamanesh Mostafavi, Alexander G. Ioannidis, Yosuke Tanigawa, Christopher DeBoever, Manuel A. Rivas
Publikováno v:
Am J Hum Genet
Whole-genome sequencing studies applied to large populations or biobanks with extensive phenotyping raise new analytic challenges. The need to consider many variants at a locus or group of genes simultaneously and the potential to study many correlat
Autor:
Evan A. Boyle, Yair Field, Anja Moltke Joergensen, Hakhamanesh Mostafavi, Jonathan K. Pritchard, Arbel Harpak, Fernando Racimo, Graham Coop, Nasa Sinnott-Armstrong, Xinjun Zhang, Jeremy J. Berg
Publikováno v:
eLife, Vol 8 (2019)
eLife
Berg, J J, Harpak, A, Sinnott-Armstrong, N, Jørgensen, A M, Mostafavi, H, Field, Y, Boyle, E A, Zhang, X, Racimo, F, Pritchard, J K & Coop, G 2019, ' Reduced signal for polygenic adaptation of height in UK Biobank ', eLife, vol. 8, e39725 . https://doi.org/10.7554/eLife.39725
eLife
Berg, J J, Harpak, A, Sinnott-Armstrong, N, Jørgensen, A M, Mostafavi, H, Field, Y, Boyle, E A, Zhang, X, Racimo, F, Pritchard, J K & Coop, G 2019, ' Reduced signal for polygenic adaptation of height in UK Biobank ', eLife, vol. 8, e39725 . https://doi.org/10.7554/eLife.39725
There is considerable variation in average height across European populations, with individuals in the northwest being taller, on average, than those in the southeast. During the past six years, a series of papers reported that polygenic scores for h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851d422d4d0fedb13936da4c78ad5755
https://escholarship.org/uc/item/2bq0m1f2
https://escholarship.org/uc/item/2bq0m1f2