Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Hakan Savli"'
2
The Mutation Profiles of K-RAS/N-RAS Genes in Metastatic Colorectal Cancer Patients
Autor: Seda EREN KESKİN, Eda GÜZDOLU, Nilüfer SERTDEMİR, Gülhan DEMİR, Deniz SÜNNETÇİ AKKOYUNLU, Devrim ÇABUK, Naci ÇİNE, Hakan SAVLI
Publikováno v: Volume: 8, Issue: 3 172-178
Kocaeli Üniversitesi Sağlık Bilimleri Dergisi
Amaç: RAS genleri, Epidermal Büyüme Faktörü Reseptörü (EGFR) tarafından indüklenen RAS-MAPK Sinyal yolağının bir üyesidir. Bu yolaktaki genlerde meydana gelen mutasyonlar kanser gelişimini tetiklemektedir. Kolorektal kanserde (KRK), RAS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e544058272f794db89b939d49156de9
https://doi.org/10.30934/kusbed.1052876
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3
The role of next-generation sequencing in the examination of signaling genes in Brca1/2-negative breast cancer cases
Autor: Naci Cine, Cansu Ugurtas, Merve Gokbayrak, Duygu Aydin, Gulhan Demir, Seda Kuru, Deniz Sunnetci‐Akkoyunlu, Seda Eren‐Keskin, Turgay Simsek, Devrim Cabuk, Maksut Gorkem Aksu, Nuh Zafer Canturk, Hakan Savli
Publikováno v: Annals of human geneticsREFERENCES.
Breast cancer is the most prevalent malignancy in women worldwide. Although pathogenic variants in the BRCA1/2 genes are responsible for the majority of hereditary breast cancer cases, a substantial proportion of patients are negative for pathogenic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a26245482f4555fb5a46fbbf23c4b6
https://pubmed.ncbi.nlm.nih.gov/36479692
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5
The diagnostic importance of pathogenic variants and variant coexistence determined by NGS-based liquid biopsy approach in patients with lung adenocarcinoma
Autor: Naci, Cine, Emin, Ali Sen, Gulhan, Demir, Merve, Gokbayrak, Eda, Guzdolu, Nilufer, Sertdemir, Duygu, Aydin, Omer, Kurtas, Seda, Reka, Deniz, Sunnetci-Akkoyunlu, Seda, Eren-Keskin, Kazim, Uygun, Devrim, Cabuk, Maksut, Gorkem Aksu, Nuh, Zafer Canturk, Hakan, Savli
Publikováno v: Molecular and Cellular Probes. 64:101819
Identification of driver mutations and rapid detection of genetic changes in lung cancer are critical in the management of the disease. Genetic structures of tumor tissues tend to change constantly and the possibility of emergence of new pathogenic v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e17803b1fc6280a47edf06d625f4c36
https://doi.org/10.1016/j.mcp.2022.101819
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6
TP53, EGFR and PIK3CA gene variations observed as prominent biomarkers in breast and lung cancer by plasma cell-free DNA genomic testing
Autor: Ercan Ozden, Ulas Isik, Maksut Görkem Aksu, Eda Guzdolu, Nilüfer Sertdemir, Ömer Kurtaş, Naci Cine, Devrim Cabuk, Kazim Uygun, Seda Reka, Duygu Aydin, Deniz Sunnetci-Akkoyunlu, Merve Ertan Gökbayrak, Hakan Savli, Gulhan Demir, Bilge Dursun, Nuh Zafer Cantürk, Seda Eren-Keskin
Publikováno v: Journal of biotechnology. 300
Use of plasma cell-free DNA genomic testing, also know as liquid biopsy, reveals information for early detection and monitoring of solid tumors. Our study reports the analysis of 113 lung and 18 breast cancer patients using commercially available pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976d4a0eb377384e3cf58d78a1948e8d
https://pubmed.ncbi.nlm.nih.gov/31100334
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7
Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period
Autor: S V Koval, Naci Cine, Hakan Savli, L M Sklyarenko, D F Gluzman, Ramis Ufuk Akkoyunlu, Deniz Sünnetçi, M P Zavelevich
Publikováno v: Turkish Journal of Hematology
Turkish Journal of Hematology, Vol 33, Iss 1, Pp 8-14 (2016)
Nuclear factor kappa B (NF-κB) is an important transcription factor in cancer and NF-κB activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-κB gene networks, leukemogenesis, and radiation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729edf0af27bc2338d42ce8e7d4f1620
http://europepmc.org/articles/PMC4805344
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8
Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis
Autor: Deniz Sunnetci-Akkoyunlu, Begum Alkan, Elif Busra Yilmaz, Bahadır Kan, V. Merve Balta, Busra Gurel, Naci Cine, Esra Guzeldemir-Akcakanat, Hakan Savli, Esen Gumuslu, Ahmet Tarik Baykal, Vakur Olgaç, Emel Akgun
Publikováno v: Journal of periodontology. 90(6)
Background: To elucidate molecular signatures of chronic periodontitis (CP) using gingival tissue samples through omics-based whole-genome transcriptomic and whole protein profiling. Methods: Gingival tissues from 18 CP and 25 controls were analyzed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3e05ab443bcbee42a5552162745829
https://pubmed.ncbi.nlm.nih.gov/30653263
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9
Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39): A Gene Expression Study
Autor: Bálint Nagy, Sara Galimberti, Giuseppe A. Palumbo, Hakan Savli, Mario Petrini, Martina Canesastraro, Francesco Di Raimondo, Deniz Sünnetçi
Publikováno v: Turkish Journal of Hematology, Vol 32, Iss 3, Pp 206-212 (2015)
Turkish Journal of Hematology
We aimed to understand the molecular pathways affected by bortezomib and arsenic trioxide treatment on myelomonocytoid cell line P39.Oligonucleotide microarray platforms were used for gene expression and pathway analysis. Confirmation studies were pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5326b6e551faf8e039cd892200d0ce
http://www.tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-78309&look4=
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10
Low frequency of HLA-B27 in ankylosing spondylitis and its relationship with clinical findings in patients from Turkey
Autor: Sevde Nur Fırat, Ayse Cefle, Baris Yilmazer, Hakan Savli, Ayten Yazici, Fulya Cosan
Objective Human leukocyte antigen B27 (HLA-B27) is strongly associated with ankylosing spondylitis (AS). However, the association between clinical findings and HLA-B27 vary in terms of geographic area. This study aimed to determine the frequency of H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b94b7bc55ffabed4a1e6d3552cbc57a
https://europepmc.org/articles/PMC5741340/
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