Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hakan Ozadam"'
Autor:
Galip Gürkan Yardımcı, Hakan Ozadam, Michael E. G. Sauria, Oana Ursu, Koon-Kiu Yan, Tao Yang, Abhijit Chakraborty, Arya Kaul, Bryan R. Lajoie, Fan Song, Ye Zhan, Ferhat Ay, Mark Gerstein, Anshul Kundaje, Qunhua Li, James Taylor, Feng Yue, Job Dekker, William S. Noble
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Hi-C is currently the most widely used assay to investigate the 3D organization of the genome and to study its role in gene regulation, DNA replication, and disease. However, Hi-C experiments are costly to perform and involve mult
Externí odkaz:
https://doaj.org/article/c5c3304bc21c457993be8f6384642f01
Autor:
Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on
Externí odkaz:
https://doaj.org/article/9651dc44fd574c31817692a66b9637db
Autor:
Maximilian H Fitz-James, Pin Tong, Alison L Pidoux, Hakan Ozadam, Liyan Yang, Sharon A White, Job Dekker, Robin C Allshire
Publikováno v:
eLife, Vol 9 (2020)
During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold. Condensin complexes are involved in chromatin compaction, but the contribution of other
Externí odkaz:
https://doaj.org/article/90cbf15aead34e1c825b881445dea004
Autor:
Nevraj S Kejiou, Lena Ilan, Stefan Aigner, Enching Luo, Tori Tonn, Hakan Ozadam, Muyoung Lee, Gregory B Cole, Ines Rabano, Nishani Rajakulendran, Brian A Yee, Hamed S Najafabadi, Trevor F Moraes, Stephane Angers, Gene W Yeo, Can Cenik, Alexander F Palazzo
Publikováno v:
Nucleic Acids Research.
In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether there are factors that regulate compartment specific mRNA translation in human cells. Using a proteomic su
Autor:
Can Cenik, Hosei Nakajima, Hakan Ozadam, Colleen M. Carlston, Brendan Panici, Elif Sarinay Cenik
Publikováno v:
Genomics
Non-canonical intronic variants are a poorly characterized yet highly prevalent class of alterations associated with Mendelian disorders. Here, we report the first RNA expression and splicing analysis from a family whose members carry a non-canonical
Autor:
Shilpa Rao, Elif Sarinay Cenik, Hakan Ozadam, Tori Tonn, Ian Hoskins, Can Cenik, P. Daniela Garcia
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
RNA
article-version (status) pre
article-version (number) 1
RNA
Viruses rely on the host translation machinery to synthesize their own proteins. Consequently, they have evolved varied mechanisms to co-opt host translation for their survival. SARS-CoV-2 relies on a non-structural protein, Nsp1, for shutting down h
Autor:
Tori Tonn, Hakan Ozadam, Crystal Han, Alia Segura, Duc Tran, David Catoe, Marc Salit, Can Cenik
Technological limitations precluded transcriptome-wide analyses of translation at single cell resolution. To solve this challenge, we developed a novel microfluidic isotachophoresis approach, named RIBOsome profiling via IsoTachoPhoresis (Ribo-ITP),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf9ea17d325b890b007c50df8ddca45
https://doi.org/10.1101/2021.12.07.471408
https://doi.org/10.1101/2021.12.07.471408
Autor:
René Maehr, Hui Mao, Job Dekker, Johan H. Gibcus, Ryan M.J. Genga, Leonid A. Mirny, Ankita Nand, Oliver J. Rando, Sergey V. Venev, Liyan Yang, Krishna Mohan Parsi, Marlies E. Oomen, Nils Krietenstein, Sameer Abraham, Betul Akgol Oksuz, Hakan Ozadam
Publikováno v:
Nature Methods
Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial organization of chromosomes and the mechanisms by which they fold. Hi-C and Micro-C are widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d27ba7e69a87d6222e4a9730e95c98
https://doi.org/10.1101/2020.12.26.424448
https://doi.org/10.1101/2020.12.26.424448
Autor:
Pin Tong, Sharon A. White, Liyan Yang, Hakan Ozadam, Job Dekker, Alison L. Pidoux, Robin C. Allshire, Maximilian H Fitz-James
Publikováno v:
Fitz-james, M, Tong, P, Pidoux, A, Ozadam, H, Yang, L, White, S, Dekker, J & Allshire, R C 2020, ' Large domains of heterochromatin direct the formation of short mitotic chromosome loops ', eLIFE, vol. 9, e57212 . https://doi.org/10.7554/eLife.57212
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold. Condensin complexes are involved in chromatin compaction, but the contribution of other