Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hakan Kucuksayan"'
Autor:
Hakan Kucuksayan, Hakan Akca
Publikováno v:
Tumor Biology, Vol 39 (2017)
Epithelial–mesenchymal transition is a crucial event for metastasis and could be mediated by several pathways such as phosphoinositide 3-kinase/Akt, mitogen-activated protein kinases, as well as many epigenetic regulators. Special AT-rich sequence-
Externí odkaz:
https://doaj.org/article/867624d7273644b48e6c0eea7bb4679c
Publikováno v:
Molecular Biology Reports. 49:39-50
Background Breast cancer (BC) is a heterogeneous disease with various subtypes, therefore, the illumination of distinctive mechanisms between subtypes for the development of novel treatment strategies is important. Here, we revealed the antiprolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ea7ed1351eb797002cdbee0ea48bba
https://doi.org/10.1007/s11033-021-06817-9
https://doi.org/10.1007/s11033-021-06817-9
TGF-β–SMAD–miR-520e axis regulates NSCLC metastasis through a TGFBR2-mediated negative-feedback loop
Autor:
Sakir Akgun, Osman N. Ozes, Egemen Dal, Hakan Kucuksayan, Hakan Akca, Arsenal Sezgin Alikanoglu, Mustafa Yildiz
Publikováno v:
Carcinogenesis. 40:695-705
Transforming growth factor-β (TGF-β) pathway plays crucial roles during the carcinogenesis and metastasis. TGF-β receptor 2 (TGFBR2) is a key molecule for the regulation of TGF-β pathway and frequently downregulated or lost in several cancer type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c150fe69dd6039f3035e462efec2087f
https://doi.org/10.1093/carcin/bgy166
https://doi.org/10.1093/carcin/bgy166
Autor:
Osman Nidai Ozes, Mustafa Yildiz, Hakan Kucuksayan, Sakir Akgun, Hakan Akca, Ozge Can, Arsenal Sezgin Alikanoglu
Background:Non-Small Cell Lung Cancer (NSCLC) is an aggressive cancer type due to high metastatic capacity. Nuclear Factor Kappa B (NF-κB) is a consistently active transcription factor in malignant lung cancer cells and has crucial significance in N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee1f8d04a6a79a5db3136a8e80be8d8
https://avesis.yyu.edu.tr/publication/details/7013df4c-b112-49f1-b4c6-04743cf9ff67/oai
https://avesis.yyu.edu.tr/publication/details/7013df4c-b112-49f1-b4c6-04743cf9ff67/oai
Publikováno v:
Lung Cancer. 98:122-129
Objectives: The epithelial-to-mesenchymal transition (EMT) is considered as a key step in invasion of cancer cells. There are several regulator proteins responsible for induction of EMT, but underlying mechanisms are still unclear. SATB2 is an epigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d6ee95e302bd153e61ced45b7ba3f8
https://doi.org/10.1016/j.lungcan.2016.05.032
https://doi.org/10.1016/j.lungcan.2016.05.032
Autor:
Hakan Kucuksayan H, Sakir Akgun S
Publikováno v:
Medicinal chemistry.
Invasion is a crucial step of metastasis process that has a complex mechanism and inducible various cellular signalling pathway (SMADs, JAK/STATs, PI3K/Akt and MAP kinases). In among these pathways, Pl3K (phosphatidylinositol-3-OH kinase)/Akt/NF-A¸B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9026f3a1918194996db965ad6822abe
https://doi.org/10.4172/2161-0444.1000351
https://doi.org/10.4172/2161-0444.1000351
Publikováno v:
Volume: 42, Issue: 3 361-367
Dicle Tıp Dergisi
Dicle Tıp Dergisi
Objective: In this study, it was aimed to investigate that PON2, in hypoxia and normoxia in relation to HIF-1α transcription factor that has a role in tumour angiogenesis. Hypoxia inducible factor 1 alpha (HIF-1α) is a transcription factor which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f230062a9ca7ab7617648b37616d542
https://hdl.handle.net/11499/42897
https://hdl.handle.net/11499/42897