Výsledky vyhledávání - "Hakan Kucukdereli"

Chronic stress triggers seeking of a starvation-like state in anxiety-prone female mice

Autor: Hakan Kucukdereli, Oren Amsalem, Trent Pottala, Michelle Lim, Leilani Potgieter, Amanda Hasbrouck, Andrew Lutas, Mark L. Andermann

Publikováno v: bioRxiv

Elevated anxiety often precedes anorexia nervosa and persists after weight restoration. Patients with anorexia nervosa often describe hunger as pleasant, potentially because food restriction can be anxiolytic. Here, we tested whether chronic stress c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579c3ea80708e86c8605db9e407c029e
https://europepmc.org/articles/PMC10245771/

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The neural basis for fasting activation of the hypothalamic-pituitary adrenal axis

Autor: Jon Resch, Amelia Douglass, Joseph Madara, Hakan Kucukdereli, Ofer Yizhar, Abhinav Grama, Masahito Yamagata, Zongfang Yang, Bradford Lowell

Publikováno v: Physiology. 38

Fasting initiates a multitude of adaptations to allow survival. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequent release of glucocorticoid hormones is a key response that mobilizes fuel stores to meet energy demands. Despite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35f426d031792697b26a915c446330f7
https://doi.org/10.1152/physiol.2023.38.s1.5726127

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State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala

Autor: Veronica E. Diaz, Andrew Lutas, Mark L. Andermann, Crista Carty, Vanessa Flores-Maldonado, Osama Alturkistani, Hakan Kucukdereli, Kayla Fernando, Arthur U. Sugden

Publikováno v: Nature neuroscience

Basal amygdala (BA) neurons guide associative learning via acquisition of responses to stimuli that predict salient appetitive or aversive outcomes. We examined the learning- and state-dependent dynamics of BA neurons and ventral tegmental area dopam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c841bd63414f91382f62441b19cac9
http://europepmc.org/articles/PMC6858554

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Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents

Autor: Joseph C. Madara, Gerald I. Shulman, Rachel J. Perry, Jon M. Resch, Amelia M. Douglass, Hakan Kucukdereli, Chen Wu, Bradford B. Lowell, Aviva Rabin-Court, Joongyu D. Song

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Low levels of leptin, a hormone secreted by adipocytes that signals the body as to the availability of fuel stores, are known to increase food intake. Here, we demonstrate a mechanism by which low leptin stimulates food intake in rodents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb9b872ef7a600af696842b63d97a3d
https://doi.org/10.1073/pnas.1901795116

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Central amygdala circuits modulate food consumption through a positive-valence mechanism

Autor: Andreas Lüthi, Amelia M. Douglass, Marion Ponserre, Rüdiger Klein, Cornelia Strobel, Karl-Klaus Conzelmann, Jan Gründemann, Pilar L. Alcala Morales, Hakan Kucukdereli, Milica Markovic

Publikováno v: Nature Neuroscience. 20:1384-1394

The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36681f0726c8f239fbfb92d7dc355560
https://doi.org/10.1038/nn.4623

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Central amygdala circuits modulate food consumption through a positive valence mechanism

Autor: Jan Gründemann, Hakan Kucukdereli, Rüdiger Klein, Marion Ponserre, Andreas Lüthi, Cornelia Strobel, Karl-Klaus Conzelmann, Pilar L. Alcala Morales, Milica Markovic, Amelia M. Douglass

SummaryThe complex behaviors underlying the pursuit and consumption of rewards are integral to an organism’s survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a665eb4ed3be6e880aa376126c788c

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Intrinsic circuits in the lateral central amygdala

Autor: Yajie Sun, Hakan Kucukdereli, Ruediger Klein, Pankaj Sah, Sarah Hunt

Publikováno v: eNeuro

Network activity in the lateral central amygdala (CeL) plays a crucial role in fear learning and emotional processing. However, the local circuits of the CeL are not fully understood and have only recently begun to be explored in detail. Here, we cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eeb8600826b819de7ebf450d2ebc62
https://hdl.handle.net/11858/00-001M-0000-002D-BE88-A11858/00-001M-0000-002D-BE86-E

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Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

Autor: Hakan Kucukdereli, Laura M. Conatser, Ben A. Barres, E. Helene Sage, Chandrani Chakraborty, Gail Workman, Cagla Eroglu, Matthew S. Weaver, Ava Feng, Nicola J. Allen, Anthony T. Lee, M. Ilcim Ozlu

Publikováno v: Proceedings of the National Academy of Sciences. 108

Astrocytes regulate synaptic connectivity in the CNS through secreted signals. Here we identified two astrocyte-secreted proteins, hevin and SPARC, as regulators of excitatory synaptogenesis in vitro and in vivo. Hevin induces the formation of synaps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7afa6cc207d52f059101008d66dbeb
https://doi.org/10.1073/pnas.1104977108

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