Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Hakan Cam"'
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-30 (2022)
Abstract Despite recent advances in cancer therapeutics, glioblastoma (GBM) remains one of the most difficult cancers to treat in both the primary and recurrent settings. GBM presents a unique therapeutic challenge given the immune-privileged environ
Externí odkaz:
https://doaj.org/article/5c89ef181a664b1f8a3be54c291b7f46
Autor:
Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181885 (2017)
STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a n
Externí odkaz:
https://doaj.org/article/1e0e13539a7340a3a783709d729e834f
Autor:
Terry J. Shackleford, Seethalakshmi Hariharan, Angelina V. Vaseva, Karina Alagoa, Maricruz Espinoza, Hemant K. Bid, Fuyang Li, Haihong Zhong, Doris A. Phelps, Ryan D. Roberts, Hakan Cam, Cheryl A. London, Denis C. Guttridge, Yidong Chen, Manjeet Rao, Yuzuru Shiio, Peter J. Houghton
Publikováno v:
Molecular Cancer Therapeutics. 22:539-550
Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc1a9c642cb58054bfc64c2b503e27f7
https://doi.org/10.1158/1535-7163.mct-20-0625
https://doi.org/10.1158/1535-7163.mct-20-0625
Autor:
Peter J. Houghton, Yuzuru Shiio, Manjeet Rao, Yidong Chen, Denis C. Guttridge, Cheryl A. London, Hakan Cam, Ryan D. Roberts, Doris A. Phelps, Haihong Zhong, Fuyang Li, Hemant K. Bid, Maricruz Espinoza, Karina Alagoa, Angelina V. Vaseva, Seethalakshmi Hariharan, Terry J. Shackleford
Supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d321c73b0c1dff621814f82b8502466
https://doi.org/10.1158/1535-7163.22551828
https://doi.org/10.1158/1535-7163.22551828
Autor:
Peter J. Houghton, Yuzuru Shiio, Manjeet Rao, Yidong Chen, Denis C. Guttridge, Cheryl A. London, Hakan Cam, Ryan D. Roberts, Doris A. Phelps, Haihong Zhong, Fuyang Li, Hemant K. Bid, Maricruz Espinoza, Karina Alagoa, Angelina V. Vaseva, Seethalakshmi Hariharan, Terry J. Shackleford
Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the mechanisms of resistance may identify combination therapies that optimize efficacy of IGF-1R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1804d9a552368da113b80c4dfbd4aafd
https://doi.org/10.1158/1535-7163.c.6534783.v1
https://doi.org/10.1158/1535-7163.c.6534783.v1
Autor:
Hakan Cam, Peter J. Houghton, Jiayuh Lin, Raushan T. Kurmasheva, Anthony Audino, Maren Cam, Ryan D. Roberts, Hemant K. Bid
PDF file - 408K, deltaNp63alpha induces cell migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951c5feb47b9ea1e70c1cd32f8e1e6b0
https://doi.org/10.1158/0008-5472.22400168.v1
https://doi.org/10.1158/0008-5472.22400168.v1
Autor:
Hakan Cam, Peter J. Houghton, Jiayuh Lin, Raushan T. Kurmasheva, Anthony Audino, Maren Cam, Ryan D. Roberts, Hemant K. Bid
PDF file - 143K, Cell cycle analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602a5b0b4107aaeb9cec62bd68386361
https://doi.org/10.1158/0008-5472.22400159
https://doi.org/10.1158/0008-5472.22400159
Autor:
Hakan Cam, Peter J. Houghton, Jiayuh Lin, Raushan T. Kurmasheva, Anthony Audino, Maren Cam, Ryan D. Roberts, Hemant K. Bid
The tumor suppressor gene p53 and its family members p63/p73 are critical determinants of tumorigenesis. ΔNp63 is a splice variant of p63, which lacks the N-terminal transactivation domain. It is thought to antagonize p53-, p63-, and p73-dependent t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a77697c384cdb27ebafe5b8a5f26fe8c
https://doi.org/10.1158/0008-5472.c.6505514
https://doi.org/10.1158/0008-5472.c.6505514
Autor:
Peter J. Houghton, Qishen Pang, Christopher E. Pelloski, Hakan Cam, Doris Phelps, Duane Oswald, Changxian Shen
Supplementary Figure S3 - PDF file 2191K, The mTOR Pathway Regulates ATM Checkpoint in Response to ICL via Sustaining FANCD2 in Rh30 Cells. A, model of the control of FANCD2 by PI3K-Akt-mTORC1-S6K1 axis. B, a hypothetic model of the regulation of ATM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639a86767e5985b917bc0acc5531dc17
https://doi.org/10.1158/0008-5472.22395854
https://doi.org/10.1158/0008-5472.22395854
Autor:
Hakan Cam, Peter J. Houghton, Jiayuh Lin, Raushan T. Kurmasheva, Anthony Audino, Maren Cam, Ryan D. Roberts, Hemant K. Bid
PDF file - 89K, Knockdown of endogenous deltaNp63 in neuroblastoma and osteosarcoma cell lines reduces cell proliferation and colony formation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa4fe681c777067693fee52f414dd85
https://doi.org/10.1158/0008-5472.22400171
https://doi.org/10.1158/0008-5472.22400171