Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Hakan, Kalay"'
Autor:
Brigitte-Carole Keumatio Doungtsop, MSc, Eleonora Nardini, MSc, Hakan Kalay, BSc, Serge A. Versteeg, MSc, Joyce Lübbers, PhD, Gaby van Barneveld, MSc, Eveline R.J. Li, PhD, Sandra J. van Vliet, PhD, Ronald van Ree, PhD, Esther C. de Jong, PhD, Yvette van Kooyk, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 1, Pp 100193- (2024)
Background: House dust mite extract–based allergen immunotherapy (AIT) to treat house dust mite allergy is substantially effective but still presents some safety and efficacy concerns that warrant improvement. Several major allergen-based approache
Externí odkaz:
https://doaj.org/article/7470b0bb5873499a871f5e4c9cea61fc
Autor:
Aram M. de Haas, Dorian A. Stolk, Sjoerd T. T. Schetters, Laura Goossens-Kruijssen, Eelco Keuning, Martino Ambrosini, Louis Boon, Hakan Kalay, Gert Storm, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 581 (2024)
Cancer vaccines have emerged as a potent strategy to improve cancer immunity, with or without the combination of checkpoint blockade. In our investigation, liposomal formulations containing synthetic long peptides and α-Galactosylceramide, along wit
Externí odkaz:
https://doaj.org/article/2be967ab56b14c11a0144b1c553fc930
Autor:
Dorian A. Stolk, Sophie K. Horrevorts, Sjoerd T.T. Schetters, Laura J.W. Kruijssen, Sanne Duinkerken, Eelco Keuning, Martino Ambrosini, Hakan Kalay, Rieneke van de Ven, Juan J. Garcia-Vallejo, Tanja D. de Gruijl, Sandra J. van Vliet, Yvette van Kooyk
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss , Pp 315-328 (2021)
Induction of tumor-specific cytotoxic CD8+ T cells (CTLs) via immunization relies on the presentation of tumor-associated peptides in major histocompatibility complex (MHC) class I molecules by dendritic cells (DCs). To achieve presentation of exogen
Externí odkaz:
https://doaj.org/article/2ff62c35b69d455394582a46f07cde98
Autor:
Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer vaccination aims to activate immunity towards cancer cells and can be achieved by delivery of cancer antigens together with immune stimulatory adjuvants to antigen presenting cells (APC). APC maturation and antigen processing is a subsequent p
Externí odkaz:
https://doaj.org/article/42a73ed18e1e4c2ba3e4049a3d626210
Autor:
Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodríguez, Anno Saris, Eline S. Zwart, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased express
Externí odkaz:
https://doaj.org/article/4b4b49035970432f8d4a489d0e951e6f
Autor:
Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries, Yvette van Kooyk
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms of disease pathogenesis have been widely s
Externí odkaz:
https://doaj.org/article/22f87aeffcb24a268513be628fe3e17d
Autor:
Rui-Jún Eveline Li, Aram de Haas, Ernesto Rodríguez, Hakan Kalay, Anouk Zaal, Connie R. Jimenez, Sander R. Piersma, Thang V. Pham, Alex A. Henneman, Richard R. de Goeij-de Haas, Sandra J. van Vliet, Yvette van Kooyk
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dendritic cells (DCs) are key initiators of the adaptive immunity, and upon recognition of pathogens are able to skew T cell differentiation to elicit appropriate responses. DCs possess this extraordinary capacity to discern external signals using re
Externí odkaz:
https://doaj.org/article/940058aa5a7547b08562962f35f58f1e
Autor:
Gert Storm, Maarten Nijen Twilhaar, Lucas Czentner Colomo, Joanna Grabowska, Alsya Affandi, Katarina Olesek, Hakan Kalay, Rene van Nostrum, Paul Crocker, Yvette van Kooyk, Joke den Haan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/b21fdaa09dd94dd0aa3e0e719bd81c27
Autor:
Dorian A. Stolk, Aram de Haas, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells
Externí odkaz:
https://doaj.org/article/c34750f04c244109b186f6110b88e981
Autor:
Anouk Zaal, R. J. Eveline Li, Joyce Lübbers, Sven C. M. Bruijns, Hakan Kalay, Yvette van Kooyk, Sandra J. van Vliet
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Many tumors display alterations in the biosynthetic pathways of glycosylation, resulting in increased expression of specific tumor-associated glycan structures. Expression of these altered glycan structures is associated with metastasis and poor prog
Externí odkaz:
https://doaj.org/article/8a27b1db633d48458fb6323a7077b1d0