Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hak-Yeop Kim"'
Autor:
Jeong-Hoon Lee, Won Young Tak, Yoon Lee, Min-Kyu Heo, Jae-Sung Song, Hak-Yeop Kim, Soo Young Park, Si Hyun Bae, Joon Hyeok Lee, Jeong Heo, Ki-Hwan Kim, Yong-Soo Bae, Yoon Jun Kim
Publikováno v:
OncoImmunology, Vol 6, Iss 7 (2017)
Our previous phase I/IIA study showed that autologous dendritic cells (DCs) pulsed with tumor-associated antigens are well tolerated in patients with hepatocellular carcinoma (HCC). In this randomized, multicenter, open-label, phase II trial, we inve
Externí odkaz:
https://doaj.org/article/48211050f2024250995ecfd7f22876c5
Autor:
Byoung Jin Kim, Seong Jun Han, Hak Yeop Kim, Michael R Stallcup, Mee Hyun Lee, Jeong Hoon Kim, Jun Hyun Kim
Publikováno v:
Journal of Molecular Endocrinology. 35:449-464
Estrogen-dependent transcriptional activation by estrogen receptor alpha (ERalpha) depends on the conformation of helices 3 and 12 in the ligand-binding domain. To better understand the function of helix 3 in ERalpha, we examined the role of charged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f903b6c542c33a9d28bf3ef7ab695493
https://doi.org/10.1677/jme.1.01846
https://doi.org/10.1677/jme.1.01846
Autor:
Jia-Ling Teo, Jong Ryul Ha, Randall T. Moon, Hong Ma, Katayoon H. Emami, Sung Hwan Moon, Hak Yeop Kim, Kwang Won Jeong, Se Woong Oh, Masakatsu Eguchi, Cu Nguyen, Michael G. Kahn, Dae Hoon Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 101:12682-12687
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8607e50ab72242bf4b83c4cba136199
https://doi.org/10.1073/pnas.0404875101
https://doi.org/10.1073/pnas.0404875101
Autor:
Byeng Hwa Jeon, Hak-Yeop Kim, Pan Dong Ryu, Jin Bong Park, Kiho Lee, Kwang-Jin Kim, Lae-Sung Kwon
Publikováno v:
Journal of Cardiovascular Pharmacology. 42:648-655
A novel pure class III antiarrhythmic agent, 1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphen-ethyl)-N-methylamino]ethane hydrochloride (KCB-328) prolongs action potential duration (APD) by blocking the rapid component delayed rectifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34f03021600fba05c8e10588b3b2883
https://doi.org/10.1097/00005344-200311000-00011
https://doi.org/10.1097/00005344-200311000-00011
Publikováno v:
Thrombosis and Haemostasis. 86:1512-1520
SummaryThe antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor (Ki = 4.9 nM) was evaluated in rat models of venous thrombosis combined with a bleeding time test and arterial thrombosis.After drugs were given by i. v. bolus injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82add585c3060810da34e4a87b9596c8
https://doi.org/10.1055/s-0037-1616756
https://doi.org/10.1055/s-0037-1616756
Autor:
Hak-Yeop Kim, ET AL. ET AL.
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90dcdcf47fc6f327f484bf609a1b4500
https://doi.org/10.1002/chin.199919092
https://doi.org/10.1002/chin.199919092
Autor:
Masahiro Nishimoto, Kazumi Morikawa, Takaaki Yoneya, Yoshihito Ohtake, Iwao Ohizumi, Hyun-Suk Lim, Kenji Taniguchi, Hak Yeop Kim, Myung Hwa Kim, Hiroshi Araya, Jae Chon Jo, Setsu Kawata, Yoshiaki Nabuchi, Shin ichi Kaiho, Yoshitake Kanbe, Toshiaki Tsunenari, Hee An Kwon
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(18)
In order to develop orally active pure antiestrogens, we incorporated the carboxy-containing side chains into the 7alpha-position of the steroid scaffold and found that 17-keto derivative CH4893237 (12b) functioned as a pure antiestrogen with its ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a3de678a610fe3544444e63fe7eb5a
https://pubmed.ncbi.nlm.nih.gov/16806917
https://pubmed.ncbi.nlm.nih.gov/16806917
Autor:
Jae Chon Jo, Hee An Kwon, Masahiro Nishimoto, Iwao Ohizumi, Toshiaki Tsunenari, Hak Yeop Kim, Kenji Taniguchi, Yoshitake Kanbe, Yoshiaki Nabuchi, Shin ichi Kaiho, Yoshihito Ohtake, Myung Hwa Kim, Setsu Kawata, Kazumi Morikawa, Hyun-Suk Lim
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(15)
In order to search for alternatives to the sulfoxide moiety in the long side chain of pure antiestrogens, several molecules that may interact with water in a fashion similar to ICI164,384 were designed and it was found that compounds with the carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9403c7d5ed4805414fa6ed92ca8c013b
https://pubmed.ncbi.nlm.nih.gov/16709454
https://pubmed.ncbi.nlm.nih.gov/16709454
Autor:
Shin ichi Kaiho, Toshiaki Tsunenari, Yoshitake Kanbe, Jae Chon Jo, Kenji Taniguchi, Masahiro Nishimoto, Yoshihito Ohtake, Iwao Ohizumi, Hak Yeop Kim, Hyun-Suk Lim, Nobuaki Kato, Kazumi Morikawa, Myung Hwa Kim
Publikováno v:
Bioorganicmedicinal chemistry. 14(14)
In order to develop pure antiestrogens, a series of 7-hydroxy-3-(4-hydroxyphenyl)-3-methylchroman and 7-hydroxy-3-(4-hydroxyphenyl)-3-methylthiochroman derivatives with sulfoxide containing side chains at the 4-position were designed, synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155f0a84f433498f8463e892a7b83888
https://pubmed.ncbi.nlm.nih.gov/16580210
https://pubmed.ncbi.nlm.nih.gov/16580210
Autor:
Katayoon H, Emami, Cu, Nguyen, Hong, Ma, Dae Hoon, Kim, Kwang Won, Jeong, Masakatsu, Eguchi, Randall T, Moon, Jia-Ling, Teo, Se Woong, Oh, Hak Yeop, Kim, Sung Hwan, Moon, Jong Ryul, Ha, Michael, Kahn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(34)
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of beta-catenin-responsive genes. To identify small molecule antagonists of this pathway, we challenged transformed colorectal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::401aad5cf141822a68e52ac45a0e4698
https://pubmed.ncbi.nlm.nih.gov/15314234
https://pubmed.ncbi.nlm.nih.gov/15314234