Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hajnalka L. Pálinkás"'
Autor:
Hajnalka L Pálinkás, Angéla Békési, Gergely Róna, Lőrinc Pongor, Gábor Papp, Gergely Tihanyi, Eszter Holub, Ádám Póti, Carolina Gemma, Simak Ali, Michael J Morten, Eli Rothenberg, Michele Pagano, Dávid Szűts, Balázs Győrffy, Beáta G Vértessy
Publikováno v:
eLife, Vol 9 (2020)
Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we
Externí odkaz:
https://doaj.org/article/cf7a1b9f9d9c42cda6d001319a1a4ee2
Autor:
Lívia Marton, Nóra Kucsma, Richard Izrael, Gergely N. Nagy, Hajnalka L Pálinkás, Beáta G. Vértessy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
The phospholipid biosynthesis of the malaria parasite, Plasmodium falciparum is a key process for its survival and its inhibition is a validated antimalarial therapeutic approach. The second and rate-limiting step of the de novo phosphatidylcholine b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7389d33e84ecb261548a900a0b71819c
https://doi.org/10.1038/s41598-020-76829-1
https://doi.org/10.1038/s41598-020-76829-1
Autor:
Lőrinc S. Pongor, Dávid Szűts, Hajnalka L Pálinkás, Michael J. Morten, Michele Pagano, Gergely Tihanyi, Gergely Róna, Eszter Holub, Carolina Gemma, Angéla Békési, Balázs Győrffy, Eli Rothenberg, Beáta G. Vértessy, Simak Ali, Gábor Papp, Ádám Póti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e3c6a78fe22ef9495ced79dff885b0
https://doi.org/10.7554/elife.60498.sa2
https://doi.org/10.7554/elife.60498.sa2
Autor:
Gergely Tihanyi, Eszter Holub, Dávid Szüts, Beáta G. Vértessy, Simak Ali, Lorinc Pongor, Gergely Róna, Michele Pagano, Angéla Békési, Michael J. Morten, Balazs Gyorffy, Carolina Gemma, Hajnalka L. Pálinkás, Eli Rothenberg, Ádám Póti
Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfcc6eec07b6d775650a19c41e1afa8
Publikováno v:
FEBS Open Bio. 8:1763-1772
Plasmodium falciparum parasites undergo multiple genome duplication events during their development. Within the intraerythrocytic stages, parasites encounter an oxidative environment and DNA synthesis necessarily proceeds under these circumstances. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b953d30651d2cf8002899e63d820272
https://doi.org/10.1002/2211-5463.12458
https://doi.org/10.1002/2211-5463.12458
Autor:
László Hiripi, Gergely Rácz, Orsolya Ivett Hoffmann, Elen Gócza, Hajnalka L Pálinkás, Zoltán Gál, Gergely Tihanyi, Gergely Róna, Beáta G. Vértessy
Publikováno v:
Biomolecules
Volume 9
Issue 4
Biomolecules, Vol 9, Iss 4, p 136 (2019)
Volume 9
Issue 4
Biomolecules, Vol 9, Iss 4, p 136 (2019)
Sanitization of nucleotide pools is essential for genome maintenance. Deoxyuridine 5&prime
triphosphate nucleotidohydrolase (dUTPase) is a key enzyme in this pathway since it catalyzes the cleavage of 2&prime
deoxyuridine 5&prime
triph
triphosphate nucleotidohydrolase (dUTPase) is a key enzyme in this pathway since it catalyzes the cleavage of 2&prime
deoxyuridine 5&prime
triph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202abc53f410803542ac677e60d4e8fc
http://europepmc.org/articles/PMC6523736
http://europepmc.org/articles/PMC6523736
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3902, p 3902 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The appearance of uracil in the deoxyuridine moiety of DNA is among the most frequently occurring genomic modifications. Three different routes can result in genomic uracil, two of which do not require specific enzymes: spontaneous cytosine deaminati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ecd0ddc1062bf73fa0e467dbac20cf
https://doi.org/10.3390/ijms22083902
https://doi.org/10.3390/ijms22083902
Publikováno v:
FEBS Open Bio
Plasmodium falciparum parasites undergo multiple genome duplication events during their development. Within the intraerythrocytic stages, parasites encounter an oxidative environment and DNA synthesis necessarily proceeds under these circumstances. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78a2e5555d8439a4adce6de07ac5e69a
https://pubmed.ncbi.nlm.nih.gov/30410856
https://pubmed.ncbi.nlm.nih.gov/30410856
Autor:
Manikandan, Periyasamy, Anup K, Singh, Carolina, Gemma, Christian, Kranjec, Raed, Farzan, Damien A, Leach, Naveenan, Navaratnam, Hajnalka L, Pálinkás, Beata G, Vértessy, Tim R, Fenton, John, Doorbar, Frances, Fuller-Pace, David W, Meek, R Charles, Coombes, Laki, Buluwela, Simak, Ali
Publikováno v:
Nucleic Acids Research
Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B (A3B) expression especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08237487eb154c3b1b84f6bb9c3f6211
https://pubmed.ncbi.nlm.nih.gov/28977491
https://pubmed.ncbi.nlm.nih.gov/28977491
Autor:
Veronika Papp-Kádár, Károly Liliom, Judit Tóth, Hajnalka L Pálinkás, Oliver Ozohanics, Imre Zagyva, Károly Vékey, Ábris Bendes, Judit Szabó, Veronika Németh, Gergely Róna, Kinga Nyíri, Balázs Besztercei, Ibolya Leveles, Beáta G. Vértessy
Publikováno v:
Nucleic Acids Research
Transfer of phage-related pathogenicity islands of Staphylococcus aureus (SaPI-s) was recently reported to be activated by helper phage dUTPases. This is a novel function for dUTPases otherwise involved in preservation of genomic integrity by sanitiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec9de3b2349c9e9886535f68145aeed
https://doi.org/10.1093/nar/gku882
https://doi.org/10.1093/nar/gku882