FK506-Binding Protein 2 Participates in Proinsulin Folding

Autor: Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J. Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec

Publikováno v: Biomolecules, Vol 13, Iss 1, p 152 (2023)

Apart from chaperoning, disulfide bond formation, and downstream processing, the molecular sequence of proinsulin folding is not completely understood. Proinsulin requires proline isomerization for correct folding. Since FK506-binding protein 2 (FKBP

Externí odkaz: https://doaj.org/article/20ad96ddb7074192b89914e9a51cc41b

FK506-Binding Protein 2 Participates in Proinsulin Folding

Autor: Hoefner, Carolin, Bryde, Tenna Holgersen, Pihl, Celina, Tiedemann, Sylvia Naiga, Bresson, Sophie Emilie, Hotiana, Hajira Ahmed, Khilji, Muhammad Saad, Santos, Theodore Dos, Puglia, Michele, Pisano, Paola, Majewska, Mariola, Durzynska, Julia, Klindt, Kristian, Klusek, Justyna, Perone, Marcelo J., Bucki, Robert, Hägglund, Per Mårten, Gourdon, Pontus Emanuel, Gotfryd, Kamil, Urbaniak, Edyta, Borowiak, Malgorzata, Wierer, Michael, MacDonald, Patrick Edward, Mandrup-Poulsen, Thomas, Marzec, Michal Tomasz

Publikováno v: Hoefner, Carolin Bryde, Tenna Holgersen Pihl, Celina Tiedemann, Sylvia Naiga Bresson, Sophie Emilie Hotiana, Hajira Ahmed Khilji, Muhammad Saad Santos, Theodore Dos Puglia, Michele Pisano, Paola Majewska, Mariola Durzynska, Julia Klindt, Kristian Klusek, Justyna Perone, Marcelo J. Bucki, Robert Hägglund, Per Mårten Gourdon, Pontus Emanuel Gotfryd, Kamil Urbaniak, Edyta Borowiak, Malgorzata Wierer, Michael MacDonald, Patrick Edward Mandrup-Poulsen, Thomas Marzec, Michal Tomasz . FK506-Binding Protein 2 Participates in Proinsulin Folding. Biomolecules. 2023, 13(1)
Biomolecules

Externí odkaz: http://hdl.handle.net/10852/108037

Structural modeling of HCV NS3/4A serine protease drug-resistance mutations using end-point continuum solvation and side-chain flexibility calculations

Autor: Hajira Ahmed Hotiana, Muhammad Kamran Haider

Publikováno v: Journal of chemical information and modeling. 53(2)

Computational methods of modeling protein-ligand interactions have gained widespread application in modern drug discovery. In continuum solvation-based methods of binding affinity estimation, limited description of solvent environment and protein fle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdc904fcb9e55be3e1d5a32cd41ec96
https://pubmed.ncbi.nlm.nih.gov/23305404

FK506-Binding Protein 2 Participates in Proinsulin Folding.

Autor: Hoefner C; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Bryde TH; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark., Pihl C; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Tiedemann SN; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; SAXOCON A/S, 2830 Virum, Denmark., Bresson SE; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway., Hotiana HA; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Khilji MS; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Biology, Linderstrøm-Lang Center for Protein Science, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Punjab, Pakistan., Santos TD; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Puglia M; Proteomics Research Infrastructure, University of Copenhagen, 2200 Copenhagen, Denmark., Pisano P; Proteomics Research Infrastructure, University of Copenhagen, 2200 Copenhagen, Denmark., Majewska M; Department of Genetics, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University, 61-712 Poznań, Poland., Durzynska J; Department of Genetics, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University, 61-712 Poznań, Poland., Klindt K; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Klusek J; Laboratory of Medical Genetics, Department of Surgical Medicine, Collegium Medicum, Jan Kochanowski University, 25-406 Kielce, Poland., Perone MJ; Immuno-Endocrinology, Diabetes & Metabolism Laboratory, Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, CONICET-Universidad Austral, Buenos Aires B1629AHJ, Argentina., Bucki R; Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, 15-089 Białystok, Poland., Hägglund PM; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Gourdon PE; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Gotfryd K; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Urbaniak E; Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-712 Poznań, Poland., Borowiak M; Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-712 Poznań, Poland., Wierer M; Proteomics Research Infrastructure, University of Copenhagen, 2200 Copenhagen, Denmark., MacDonald PE; Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Mandrup-Poulsen T; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Marzec MT; Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Institute of Health Sciences, Collegium Medicum, Jan Kochanowski University, 25-406 Kielce, Poland.

Publikováno v: Biomolecules [Biomolecules] 2023 Jan 11; Vol. 13 (1). Date of Electronic Publication: 2023 Jan 11.