ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression

Autor: Kristina Riegel, Hajime Yurugi, Janine Schlöder, Helmut Jonuleit, Manuel Kaulich, Friederike Kirschner, Danielle Arnold-Schild, Stefan Tenzer, Hansjörg Schild, Krishnaraj Rajalingam

Publikováno v: Cell Death and Disease, Vol 12, Iss 11, Pp 1-14 (2021)

Abstract Tumors exhibit a variety of strategies to dampen antitumor immune responses. With an aim to identify factors that are secreted from tumor cells, we performed an unbiased mass spectrometry-based secretome analysis in lung cancer cells. Interl

Externí odkaz: https://doaj.org/article/98255791638d4d7f9a6010011fe837a6

Abstract A020: CETSA profiling unveils novel targets engaged by anti-tumor drug rigosertib to inhibit RAS-MAPK signaling and trigger NLRP3 inflammasome activation

Autor: Petros Kechagioglou, Camille Dupont, Hajime Yurugi, Alexey Chernobrovkin, Kristina Riegel, Stephen Cosenza, Steven M. Fruchtman, Krishnaraj Rajalingam

Publikováno v: Molecular Cancer Research. 21:A020-A020

Background: The importance of styryl benzyl sulfones that induce G2/M cell cycle arrest and apoptosis in tumor cells has raised interest in cancer therapeutics. Rigosertib (ON 01910.Na) has been characterized as a disruptor of multiple signaling path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46ac2620f1eb4e2011ba42ba6275d4ba
https://doi.org/10.1158/1557-3125.ras23-a020

Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors

Autor: Judith Stickdorn, Lara Stein, Danielle Arnold-Schild, Jennifer Hahlbrock, Carolina Medina-Montano, Joschka Bartneck, Tanja Ziß, Evelyn Montermann, Cinja Kappel, Dominika Hobernik, Maximilian Haist, Hajime Yurugi, Marco Raabe, Andreas Best, Krishnaraj Rajalingam, Markus P. Radsak, Sunil A. David, Kaloian Koynov, Matthias Bros, Stephan Grabbe, Hansjörg Schild, Lutz Nuhn

Publikováno v: ACS Nano

The generation of specific humoral and cellular immune responses plays a pivotal role in the development of effective vaccines against tumors. Especially the presence of antigen-specific, cytotoxic T cells influences the outcome of therapeutic cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9f646debac17e75bfa479e6d5a1492
https://pubmed.ncbi.nlm.nih.gov/35103463

Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases

Autor: Amel Djehal, Dong Wang, Laurent Désaubry, Peng Yu, Sabria Elderwish, Redouane Tabti, Hajime Yurugi, Canan G. Nebigil, Krishnaraj Rajalingam, Hussein Abou-Hamdan

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2020, 77 (18), pp.3525-3546. ⟨10.1007/s00018-020-03475-1⟩

Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f9e5ea2ee35308e854c5644c8cc413
https://hal.archives-ouvertes.fr/hal-03014862

Mannose-Decorated Multicomponent Supramolecular Polymers Trigger Effective Uptake into Antigen-Presenting Cells

Autor: Hajime Yurugi, Edgar Schmitt, Daniel Spitzer, Natascha Stergiou, David Straßburger, Dieter Schollmeyer, Pol Besenius, Moritz Urschbach

Publikováno v: ChemBioChem. 19:912-916

A modular route to prepare functional self-assembling dendritic peptide amphiphiles decorated with mannosides, to effectively target antigen-presenting cells, such as macrophages, is reported. The monomeric building blocks were equipped with tetra(et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fb644137b77a0b1d1ede205704e587
https://doi.org/10.1002/cbic.201800114