Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Hajime Takase"'
Autor:
Tomonori Hoshino, Hajime Takase, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Emiri T. Mandeville, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The corpus callosum, a major white matter tract in the brain, undergoes age-related functional changes. To extend our investigation of age-related gene expression dynamics in the mouse corpus callosum, we compared RNA-seq data from 2 week-ol
Externí odkaz:
https://doaj.org/article/12e7aa4247b14b01a7b23aaf731dc7e4
Autor:
Tomonori Hoshino, Hajime Takase, Hidehiro Ishikawa, Gen Hamanaka, Shintaro Kimura, Norito Fukuda, Ji Hyun Park, Hiroki Nakajima, Hisashi Shirakawa, Akihiro Shindo, Kyu-Won Kim, Irwin H Gelman, Josephine Lok, Ken Arai
Publikováno v:
Bioinformatics and Biology Insights, Vol 18 (2024)
A-kinase anchor protein 12 (AKAP12), a scaffold protein, has been implicated in the central nervous system, including blood-brain barrier (BBB) function. Although its expression level in the corpus callosum is higher than in other brain regions, such
Externí odkaz:
https://doaj.org/article/1fd76de251144c16af1a0bf481a6830d
Autor:
Hajime Takase, Tetsuya Yamamoto
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Meningioma is the most common primary neoplasm of the central nervous system (CNS). Generally, these tumors are benign and have a good prognosis. However, treatment can be challenging in cases with aggressive variants and poor prognoses. Among variou
Externí odkaz:
https://doaj.org/article/cdead89b340e43e7b338fa71ac341241
Autor:
Hajime Takase, Robert W Regenhardt
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 6, Pp 1144-1149 (2021)
Acute central nervous system injuries are among the most common causes of disability worldwide, with widespread social and economic implications. Motor tract injury accounts for the majority of this disability; therefore, there is impetus to understa
Externí odkaz:
https://doaj.org/article/1e5167bc2d2948859727d3c9d4866616
Autor:
Ryo Ohtomo, Hidehiro Ishikawa, Keita Kinoshita, Kelly K. Chung, Gen Hamanaka, Gaku Ohtomo, Hajime Takase, Christiane D. Wrann, Hiroshi Katsuki, Atsushi Iwata, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic re
Externí odkaz:
https://doaj.org/article/9edc09523ab84bf68816a3ad42d52779
Autor:
Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Hidehiro Ishikawa, Kelly K. Chung, Emiri T. Mandeville, Josephine Lok, Myriam Fornage, Karl Herrup, Kai-Hei Tse, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
White matter damage caused by cerebral hypoperfusion is a major hallmark of subcortical ischemic vascular dementia (SIVD), which is the most common subtype of vascular cognitive impairment and dementia (VCID) syndrome. In an aging society, the number
Externí odkaz:
https://doaj.org/article/25f21b31cb26423c8c40c5188442765d
Publikováno v:
Brain Circulation, Vol 4, Iss 3, Pp 118-123 (2018)
There are currently no adequate treatments for white-matter injury, which often follows central nervous system maladies and their accompanying neurodegenerative processes. Indeed, the white matter is compromised by the deterioration of the blood–br
Externí odkaz:
https://doaj.org/article/ffb5b754e86a4afbbf003fc7a5643a8a
Autor:
Ji Hae Seo, Takakuni Maki, Nobukazu Miyamoto, Yoon Kyong Choi, Kelly K. Chung, Gen Hamanaka, Ji Hyun Park, Emiri T. Mandeville, Hajime Takase, Kazuhide Hayakawa, Josephine Lok, Irwin H. Gelman, Kyu-Won Kim, Eng H. Lo, Ken Arai
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9078 (2020)
A-kinase anchor protein 12 (AKAP12) is a scaffolding protein that associates with intracellular molecules to regulate multiple signal transductions. Although the roles of AKAP12 in the central nervous system are still relatively understudied, it was
Externí odkaz:
https://doaj.org/article/a530e485410749549741b8fa74292755
Publikováno v:
Brain Circulation, Vol 2, Iss 3, Pp 121-125 (2016)
Oligodendrocyte precursor cells (OPCs), which give rise to mature oligodendrocytes (OLs), play important roles in maintaining white matter function. Even during the adulthood period, OPCs comprise roughly 5% of all cells in the forebrain and retain a
Externí odkaz:
https://doaj.org/article/8c06d926673c4e8093b9131cb80a8498
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184258 (2017)
Nogo receptor-1 (NgR1) and its ligands inhibit neuronal plasticity and limit functional recovery after brain damage such as ischemic stroke. We have previously shown that lateral olfactory tract usher substance (LOTUS) antagonizes NgR1-mediated signa
Externí odkaz:
https://doaj.org/article/52479099e2814d41a0faa826255d1049