Výsledky vyhledávání - "Hajime Koganei"

Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives

Autor: Seiji Ohno, Masataka Shoji, Akira Takahara, Tomoko Takeda, Munetaka Tokumasu, Satoshi Iwayama, Seinosuke Iwata, Shinichi Fujita, Masako Hagihara, Seiji Niwa, Hajime Koganei, Takashi Yamamoto, Tomoyuki Onishi, Yuki Saitou

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:3639-3642

A structure–activity relationship study of 6-unsubstituted-1,4-dihydropyridine and 2,6-unsubstituted-1,4-dihydropyridine derivatives was conducted in an attempt to discover N-type calcium channel blockers that were highly selective over L-type calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11785669960d9f5c026406e75f70952d
https://doi.org/10.1016/j.bmcl.2012.04.051

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The structure–activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels

Autor: Shinichi Fujita, Seiji Ohno, Seiji Niwa, Hajime Koganei, Yuki Saitou, Seinosuke Iwata, Akira Takahara, Tomoko Takeda, Tomoyuki Onishi, Takashi Yamamoto, Munetaka Tokumasu, Chika Nakanishi, Morikazu Kito, Akira Nakajo, Yukitsugu Ono, Masataka Shoji, Yoko Masuzawa

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:4813-4816

In order to find an injectable and selective N-type calcium channel blocker, we have performed the structure-activity relationship (SAR) study on the 2-, 5-, and 6-position of 1,4-dihydropyridine-3-carboxylate derivative APJ2708 (2), which is a deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86b1d751e45f33b333b46f09d74e181
https://doi.org/10.1016/j.bmcl.2008.07.096

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Structure–activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels

Autor: Akira Takahara, Seiji Ohno, Hiroyuki Matsueda, Hisayuki Uneyama, Masataka Shoji, Shinichi Fujita, Tomoko Takeda, Seinosuke Iwata, Tomoyuki Onishi, Seiji Niwa, Morikazu Kito, Hajime Koganei, Yuki Saitou, Yukitsugu Ono, Takashi Yamamoto

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:798-802

Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity. In order to find specific N-type calcium channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e409c773f0b8a9e6feef5d47c8042074
https://doi.org/10.1016/j.bmcl.2005.11.021

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Antisympathetic and hemodynamic property of a dual L/N-type Ca2+ channel blocker cilnidipine in rats

Autor: Seinosuke Iwata, Akira Takahara, Tomoko Takeda, Hajime Koganei

Publikováno v: European Journal of Pharmacology. 434:43-47

The in vivo antisympathetic property of a dual L/N-type Ca(2+) channel blocker cilnidipine compared with that of typical N-type Ca(2+) channel blockers has never been clarified. We investigated the effects of the drug on a sympathetic nerve-mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8671442a5e1660499867a49f60ed7b
https://doi.org/10.1016/s0014-2999(01)01521-7

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Asymmetric synthesis and biological evaluations of (+)- and (−)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

Autor: Seiji Ohno, Akira Takahara, Yuki Saitou, Munetaka Tokumasu, Shinichi Fujita, Seinosuke Iwata, Tomoko Takeda, Masako Hagihara, Satoshi Iwayama, Seiji Niwa, Hajime Koganei, Takashi Yamamoto, Masataka Shoji

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:3317-3319

An efficient asymmetric synthesis of 1,4-dihydropyridine derivatives is described. The key step is the stereoselective Michael addition using t-butyl ester of L-valine as a chiral auxiliary to achieve good ee (>95% for all the tested experiments) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0493b5edab6479967db8b370748fef72
https://doi.org/10.1016/j.bmcl.2011.04.007

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AT-1015, a Novel Serotonin (5-HT)2 Receptor Antagonist, Blocks Vascular and Platelet 5-HT2A Receptors and Prevents the Laurate-Induced Peripheral Vascular Lesion in Rats

Autor: Hiroshi Yamamoto, Tsukao Nishimori, Ayahito Kimura, Hideaki Kihara, Ken Hirose, Noriko Sasaki, Ryota Yoshimoto, Hajime Koganei, Masataka Shoji

Publikováno v: Journal of Cardiovascular Pharmacology. 35:523-530

The serotonin (5-HT2A) antagonistic activities and the protective effect on laurate-induced peripheral vascular lesions of AT-1015, a novel 5-HT2 receptor antagonist, were investigated. In platelet aggregation, AT-1015 selectively inhibited in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fbfac60053f2e2edf05db555b4297e
https://doi.org/10.1097/00005344-200004000-00002

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Effects of Yohimbine and Desipramine on Adrenal Catecholamine Release in Response to Splanchnic Nerve Stimulation in Anesthetized Dogs

Autor: Hajime Koganei, Tomohiko Kimura, Akihiko Takeuchi, Susumu Satoh

Publikováno v: Biological and Pharmaceutical Bulletin. 18:1207-1210

The effects of yohimbine and desipramine on adrenal catecholamine (CA) release in response to splanchnic nerve stimulation (SNS) were examined in anesthetized dogs. SNS and 3 Hz produced frequency-dependent increases in epinephrine (EPI) and norepine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f9879012b0b9ce1e3727fcb45adf47
https://doi.org/10.1248/bpb.18.1207

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Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker

Autor: Seinosuke Iwata, Masataka Shoji, Hajime Koganei

Publikováno v: Biologicalpharmaceutical bulletin. 32(10)

Cilnidipine is a 1,4-dihydropyridine-derived voltage-dependent calcium channel (VDCC) blocker and suppresses N-type VDCC currents in addition to L-type VDCC currents. An earlier investigation has suggested that intrathecally injected cilnidipine prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4020e608b274b7fdfd16341e410fea
https://pubmed.ncbi.nlm.nih.gov/19801830

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The N-type and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-salt diet

Autor: Hajime Koganei, Hirotaka Wagatsuma, Tetsuya Ogawa, Shizuka Aritomi, Akira Mitsui, Tomoyuki Konda, Kosaku Nitta

Publikováno v: Heart and vessels. 25(6)

The aims of the present study were to compare the effects of cilnidipine [L-type/N-type calcium channel blocker (CCB)] and amlodipine (L-type CCB) alone or in combination with the angiotensin II receptor blocker (ARB), valsartan, on blood pressure (B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a987f03db5a1ca3cb3825b2c51a07b
https://pubmed.ncbi.nlm.nih.gov/20922532

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Different effects of L/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR/Izm

Autor: Tomoyuki Konda, Hajime Koganei, Tetsuya Ogawa, Kosaku Nitta, Shizuka Aritomi, Kazumi Niinuma, Azusa Enomoto

Publikováno v: American journal of nephrology. 30(2)

Background: The L/N-type calcium channel blocker (CCB) cilnidipine has been demonstrated to suppress sympathetic nerve activity. In the present study, we investigated the effects of cilnidipine on the renin-angiotensin-aldosterone system (RAAS) in SH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb186b381bd4d7ec777f1b89a6ef18b7
https://pubmed.ncbi.nlm.nih.gov/19325231

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