Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Hajime Kashima"'
Autor:
Hajime Kashima, Anthony Fischer, Daniel A. Veronese-Paniagua, Vered A. Gazit, Changqing Ma, Yan Yan, Marc S. Levin, Blair B. Madison, Deborah C. Rubin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101390- (2024)
Background & Aims: Human sporadic colorectal cancer (CRC) results from a multistep pathway with sequential acquisition of specific genetic mutations in the colorectal epithelium. Modeling CRC in vivo is critical for understanding the tumor microenvir
Externí odkaz:
https://doaj.org/article/6221a5a5b34c4ac284856ab1240e529b
Autor:
Hiroaki Sato, Kazuhiro Noma, Toshiaki Ohara, Kento Kawasaki, Masaaki Akai, Teruki Kobayashi, Noriyuki Nishiwaki, Toru Narusaka, Satoshi Komoto, Hajime Kashima, Yuki Katsura, Takuya Kato, Satoru Kikuchi, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Hisataka Kobayashi, Toshiyoshi Fujiwara
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Cancer-associated fibroblasts (CAFs) play a significant role in tumor progression within the tumor microenvironment. Previously, we used near-infrared photoimmunotherapy (NIR-PIT), a next-generation cancer cell-targeted phototherapy, to esta
Externí odkaz:
https://doaj.org/article/756adf4384794ffba953a85b09b706b8
Autor:
Kosei Takagi, Kazuhiro Noma, Yasuo Nagai, Satoru Kikuchi, Yuzo Umeda, Ryuichi Yoshida, Tomokazu Fuji, Kazuya Yasui, Takehiro Tanaka, Hajime Kashima, Takahito Yagi, Toshiyoshi Fujiwara
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundCancer-associated fibroblasts (CAFs) reportedly enhance the progression of gastrointestinal surgery; however, the role of CAFs in ampullary carcinomas remains poorly examined. This study aimed to investigate the effect of CAFs on the surviv
Externí odkaz:
https://doaj.org/article/cd696470da1444c9a528ea952cf0f9bd
Autor:
Ryoichi Katsube, Kazuhiro Noma, Toshiaki Ohara, Noriyuki Nishiwaki, Teruki Kobayashi, Satoshi Komoto, Hiroaki Sato, Hajime Kashima, Takuya Kato, Satoru Kikuchi, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Hisataka Kobayashi, Toshiyoshi Fujiwara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells. Near-infrare
Externí odkaz:
https://doaj.org/article/edf5fed397e64f0e8fa9e8ebc6976513
Autor:
Hajime Kashima, Fumiyasu Momose, Hiroshi Umehara, Nao Miyoshi, Naohisa Ogo, Daisuke Muraoka, Hiroshi Shiku, Naozumi Harada, Akira Asai
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156643 (2016)
Forkhead box protein p3 (Foxp3) is crucial to the development and suppressor function of regulatory T cells (Tregs) that have a significant role in tumor-associated immune suppression. Development of small molecule inhibitors of Foxp3 function is the
Externí odkaz:
https://doaj.org/article/af4abd82df1e4e5bbae3febfaf2d1e8b
Autor:
Yoshihiko Kakiuchi, Shinji Kuroda, Satoru Kikuchi, Hajime Kashima, Masahiko Nishizaki, Shunsuke Kagawa, Toshiyoshi Fujiwara
Publikováno v:
Journal of Gastrointestinal Surgery. 27:643-645
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6943ea11e1a1ab1f181e960863ce9b8c
https://doi.org/10.1007/s11605-023-05600-4
https://doi.org/10.1007/s11605-023-05600-4
Autor:
Satoshi Komoto, Kazuhiro Noma, Takuya Kato, Teruki Kobayashi, Noriyuki Nishiwaki, Toru Narusaka, Hiroaki Sato, Yuki Katsura, Hajime Kashima, Satoru Kikuchi, Toshiaki Ohara, Hiroshi Tazawa, Toshiyoshi Fujiwara
Publikováno v:
Cancers; Volume 15; Issue 11; Pages: 2971
Esophageal cancer is one of the most aggressive tumors, and the outcome remains poor. One contributing factor is the presence of tumors that are less responsive or have increased malignancy when treated with conventional chemotherapy, radiotherapy, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b97b8d6efa9e60edd5bce22d147650
Autor:
Toshiyoshi Fujiwara, Yasuhiro Shirakawa, Hiroshi Tazawa, Takayuki Ninomiya, Ryoichi Katsube, Satoshi Komoto, Hiroaki Sato, Yuki Katsura, Hajime Kashima, Toshiaki Ohara, Kazuhiro Noma, Takuya Kato
Purpose: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a central role in tumor progression. We investigated whether CAFs can regulate tumor-infiltrating lymphocytes (TILs) and their role in tumor immunosuppression.Expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0e9c8fa81bc8cf1bb80112217b28b3
https://doi.org/10.1158/1078-0432.c.6527288
https://doi.org/10.1158/1078-0432.c.6527288
Autor:
Toshiyoshi Fujiwara, Yasuhiro Shirakawa, Hiroshi Tazawa, Takayuki Ninomiya, Ryoichi Katsube, Satoshi Komoto, Hiroaki Sato, Yuki Katsura, Hajime Kashima, Toshiaki Ohara, Kazuhiro Noma, Takuya Kato
Supplementary Figure 1. Subgroup analysis of TILs in intra-tumoral tissues according to UICC Stage. Supplementary Figure 2. Correlation between CAFs and ratios of peri- to intra-tumoral of CD8+ or FoxP3+ TILs. Supplementary Figure 3. Quantification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589d09aea419c2b70ebe7d710ddad525
https://doi.org/10.1158/1078-0432.22469549.v1
https://doi.org/10.1158/1078-0432.22469549.v1
Autor:
Noriyuki Nishiwaki, Kazuhiro Noma, Toshiaki Ohara, Tomoyoshi Kunitomo, Kento Kawasaki, Masaaki Akai, Teruki Kobayashi, Toru Narusaka, Hajime Kashima, Hiroaki Sato, Satoshi Komoto, Takuya Kato, Naoaki Maeda, Satoru Kikuchi, Shunsuke Tanabe, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Publikováno v:
Cancer Immunology, Immunotherapy.
Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment and play a central role in tumor progression. Previously, we reported that CAFs might induce tumor immunosuppression via interleukin-6 (IL-6) and promote tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef9b03a3190bb9c31effab7459fe09cd
https://doi.org/10.1007/s00262-023-03378-7
https://doi.org/10.1007/s00262-023-03378-7