Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Hajime KARASUYAMA"'
Autor:
John TCHEN, Quentin SIMON, Léa CHAPART, Morgane K. THAMINY, Shamila VIBHUSHAN, Loredana SAVEANU, Yasmine LAMRI, Fanny SAIDOUNE, Emeline PACREAU, Christophe PELLEFIGUES, Julie BEX-COUDRAT, Hajime KARASUYAMA, Kensuke MIYAKE, Juan HIDALGO, Padraic G. FALLON, Thomas PAPO, Ulrich BLANK, Marc BENHAMOU, Guillaume HANOUNA, Karim SACRE, Eric DAUGAS, Nicolas CHARLES
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary
Externí odkaz:
https://doaj.org/article/2b261c12033c4401a2b53ad4f143bfa7
Autor:
Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Frank Brombacher, Shigeyuki Shichino, Soichiro Yoshikawa, Sachiko Miyake, Hajime Karasuyama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Both monocytes and macrophages are heterogeneous populations. It was traditionally understood that Ly6Chi classical (inflammatory) monocytes differentiate into pro-inflammatory Ly6Chi macrophages. Accumulating evidence has suggested that Ly6
Externí odkaz:
https://doaj.org/article/b71abb01b4404290a3a8f7955fcbff5b
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
Basophils are the least common granulocytes, accounting for
Externí odkaz:
https://doaj.org/article/1224fdd49dd349e8914696cbaafeaa71
Autor:
Kensuke Miyake, Junya Ito, Jun Nakabayashi, Shigeyuki Shichino, Kenji Ishiwata, Hajime Karasuyama
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Basophils are the rarest granulocytes and are recognized as critical cells for type 2 immune responses. However, their differentiation pathway remains to be fully elucidated. Here, we assess the ontogenetic trajectory of basophils by single-
Externí odkaz:
https://doaj.org/article/973be10c0bb74553bd054f2faf407bf6
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/60aa48ef55f2494a93bf0529bb49a2d4
Autor:
John Tchen, Quentin Simon, Léa Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tissue-specific mouse models are essential tools to decipher the role of each cell compartment and/or their expressed genes in the pathophysiology of diseases. Here, we describe a new knock-in mouse model allowing expression of both the fluorescent p
Externí odkaz:
https://doaj.org/article/6d84a6fd725646d891b31d23a059b29f
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Basophils are the rarest granulocytes and have long been overlooked in immunological research due to their rarity and similarities with tissue-resident mast cells. In the last two decades, non-redundant functions of basophils have been clarified or i
Externí odkaz:
https://doaj.org/article/93e1c8e870244031abef0ad1d91211f9
Autor:
Juan-Manuel Leyva-Castillo, Mrinmoy Das, Jennifer Kane, Maria Strakosha, Sonal Singh, Daniel Sen Hoi Wong, Alexander R. Horswill, Hajime Karasuyama, Frank Brombacher, Lloyd S. Miller, Raif S. Geha
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Superficial cutaneous Staphylococcus aureus (S. aureus) infection in humans can lead to soft tissue infection, an important cause of morbidity and mortality. IL-17A production by skin TCRγδ+ cells in response to IL-1 and IL-23 produced by epithelia
Externí odkaz:
https://doaj.org/article/f92c5bebf6394434bab77102e9cc1d06
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Ticks are blood-sucking arthropods of great importance in the medical and veterinary fields worldwide. They are considered second only to mosquitos as vectors of pathogenic microorganisms that can cause serious infectious disorders, such as Lyme borr
Externí odkaz:
https://doaj.org/article/27fb88f9417b40dfbfe56d727ec81886
Autor:
Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M. Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
In a lupus environment, basophils accumulate in secondary lymphoid organs where they affect pathogenesis by stimulating autoantibody production. Here the authors show this accumulation is driven by PGD2-induced CXCR4 surface expression and traffickin
Externí odkaz:
https://doaj.org/article/80954cdc9d4244429cf721f1490b4ce5