Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Hajime, Seki"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4956-4959
Botulinum neurotoxins (BoNT) are among the most toxic known substances and currently there are no effective treatments for intraneuronal BoNT intoxication. Chicoric acid (ChA) was previously reported as a BoNT/A inhibitor that binds to the enzyme’s
Publikováno v:
Journal of the American Chemical Society. 138:5568-5575
Botulium neurotoxins (BoNTs) are among the most lethal toxins known to man. They are comprised of seven serotypes with BoNT/A being the most deadly; yet, there is no approved therapeutic for their intoxication or one that has even advanced to clinica
Autor:
Hajime Seki, Gunda I. Georg
Publikováno v:
Synlett. 25:2536-2557
This account summarizes our recent investigations into the chemistry of 2,3-dihydropyridin-4(1H)-ones and 3-aminocyclohex-2-enones (enaminones). These enaminones are exceptionally versatile chemical scaffolds that serve as valuable intermediates in t
Autor:
Gunda I. Georg, Hajime Seki
Publikováno v:
European Journal of Organic Chemistry. 2014:3777-3783
An enantiospecific synthesis of a nuphar alkaloid was achieved in nine steps from N-Boc-(L)-proline. The alkaloid is a minor component of castoreum, which is secreted from the dried scent glands of a beaver. During the course of our study, the stereo
Autor:
Sabine Pellett, B. Blanco, Kim D. Janda, Eric A. Johnson, G. Neil Stowe, Peter Šilhár, Matthew Lardy, Hajime Seki
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1208-1217
Botulinum neurotoxin A (BoNT/A) is the most potent toxin known. Unfortunately, it is also a potential bioweapon in terrorism, which is without an approved therapeutic treatment once cellular intoxication takes place. Previously, we reported how hydro
E105 ASSESSMENT OF OPTIMAL ENERGY DEVICE APPLICATION FOR RESIDENCE TOWN(Distributed Energy System-1)
Publikováno v:
The Proceedings of the International Conference on Power Engineering (ICOPE). :1-257
Publikováno v:
The Proceedings of Conference of Kansai Branch. :5-24
Publikováno v:
同志社大学理工学研究報告 = The Science and Engineering Review of Doshisha University. 49(1):19-25
本研究では仮想マイクログリッドのCO2排出量、運用コストおよびエネルギ供給率を把握することを目的としている。このシステムは蓄電池や自営線の代わりに系統電源で買電および売電
Autor:
Kim D. Janda, Song Xue, Sabine Pellett, Marek Remeš, Hajime Seki, Eric A. Johnson, Mark S. Hixon
Publikováno v:
Chemical communications (Cambridge, England). 51(28)
Dyngo-4a™ has been found to be an endocytic inhibitor of BoNT/A neurotoxicity through dynamin inhibition. Herein, we demonstrate this molecule to have a previously unrecognized dual activity against BoNT/A, dynamin–protease inhibition. To establi
Autor:
Gunda I. Georg, Hajime Seki
Publikováno v:
ChemInform. 46
Total synthesis of the nuphar alkaloid (I) from N-Boc-L-proline is achieved in nine steps and it shows affinity for the oxytocin receptor.