Zobrazeno 1 - 10 of 141 pro vyhledávání: '"Hajime, Kojima"'
1
Akademický článek
Development of an Eye Irritation Test Method Using an In-House Fabrication of a Reconstructed Human Cornea-like Epithelium Model for Eye Hazard Identification
Autor: Naoki Yamamoto, Noriko Hiramatsu, Yoshinao Kato, Atsushi Sato, Hajime Kojima
Publikováno v: Bioengineering, Vol 11, Iss 4, p 302 (2024)
In a previous study, a novel human corneal-like epithelium model utilizing an immortalized human corneal epithelial cell line (iHCE-NY1) was developed as an alternative to animal models to identify chemicals not classified under the United Nations Gl
Externí odkaz: https://doaj.org/article/e5a972caf294425aa16aeed733e17d1b
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2
Elektronická kniha
Alternatives to Animal Testing : Proceedings of Asian Congress 2016
Autor: Hajime Kojima, Troy Seidle, Horst Spielmann
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the
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3
Akademický článek
A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients
Autor: Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Mio Yagi, Keiko Yamamoto, Mariko Sugiyama, Yoshiaki Ikarashi, Hitoshi Sakaguchi, Masahiko Yamaguchi, Morihiko Hirota, Sakiko Aizawa, Shota Nakagawa, Shigenobu Hagino, Masato Hatao
Publikováno v: Current Research in Toxicology, Vol 4, Iss , Pp 100100- (2023)
Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evi
Externí odkaz: https://doaj.org/article/87dee5b26ae9496ab51c2bcc9ad2ae5d
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4
Akademický článek
Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity
Autor: Aldert H. Piersma, Nancy C. Baker, George P. Daston, Burkhard Flick, Michio Fujiwara, Thomas B. Knudsen, Horst Spielmann, Noriyuki Suzuki, Katya Tsaioun, Hajime Kojima
Publikováno v: Current Research in Toxicology, Vol 3, Iss , Pp 100074- (2022)
This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide diversity
Externí odkaz: https://doaj.org/article/0e3fcdf035aa43749c37ad3ba069d7ff
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6
Akademický článek
Comparison of self-report and objective measures of male sexual dysfunction in a Japanese primary care setting: a cross-sectional, self-administered mixed methods survey
Autor: Hajime Kojima, Michael D Fetters, Yuki Takeuchi, Ryohei Otsuka
Publikováno v: Family Medicine and Community Health, Vol 9, Iss 1 (2021)
Objectives Erectile dysfunction (ED) is a common problem among middle-aged males and men often do not talk about sexual problems with their primary care physicians (PCPs). We hypothesised that many Japanese men who meet the criteria for ED would not
Externí odkaz: https://doaj.org/article/73a9faf0882a4c34b2603d1048391710
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7
Assessment of commercial polymers with and without reactive groups using amino acid derivative reactivity assay based on both molar concentration approach and gravimetric approach
Autor: Masaharu Fujita, Natsumi Nakashima, Sayaka Wanibuchi, Yusuke Yamamoto, Hajime Kojima, Atsushi Ono, Toshihiko Kasahara
Publikováno v: Journal of Applied Toxicology. 43:446-457
The amino acid derivative reactivity assay (ADRA), an alternative method for testing skin sensitization, has been established based on the molar concentration approach. However, the additional development of gravimetric concentration and fluorescence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6705c08fa0b75f7177bfa55b2ffae3
https://doi.org/10.1002/jat.4395
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8
Applicability of amino acid derivative reactivity assay (4 mM) for the prediction of skin sensitization by combining multiple alternative methods to evaluate key events
Autor: Mika Imamura, Yusuke Yamamoto, Masaharu Fujita, Sayaka Wanibuchi, Natsumi Nakashima, Hajime Kojima, Atsushi Ono, Toshihiko Kasahara
Publikováno v: Journal of Applied Toxicology. 42:1159-1167
The amino acid derivative reactivity assay (ADRA) is an alternative method for evaluating key event 1 (KE-1) in the skin sensitization mechanism included in OECD TG442C (OECD, 2021). Recently, we found that ADRA with a 4-mM test chemical solution had
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee4f93348e0edb8590d7c989a1e4b3f
https://doi.org/10.1002/jat.4283
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10
International trend regarding immunotoxicity evaluation with New Approach Methods (NAMs)
Autor: Hajime, Kojima, Takao, Ashikaga
Publikováno v: Folia Pharmacologica Japonica. 157:340-344
We have ongoing projects that are developing New Approach Methods (NAMs) for systematic toxicology. One NAM is to develop the immunotoxicity evaluation with non-animal test methods for the Organisation for Economic Co-operation and Development (OECD)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722e9949ff7d88e38c07732b1cf4ffab
https://doi.org/10.1254/fpj.22036
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