Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Hajime, Hirase"'
Autor:
Wanqin Tan, Yoko Ikoma, Yusuke Takahashi, Ayumu Konno, Hirokazu Hirai, Hajime Hirase, Ko Matsui
Publikováno v:
Neuroscience Research, Vol 205, Iss , Pp 1-15 (2024)
The potential role of astrocytes in lateral habenula (LHb) in modulating anxiety was explored in this study. The habenula are a pair of small nuclei located above the thalamus, known for their involvement in punishment avoidance and anxiety. Herein,
Externí odkaz:
https://doaj.org/article/1f4ed2c2340348d682e3d2be3d27d7bb
Autor:
Antonios Asiminas, Ryszard S. Gomolka, Stefanie Gregoriades, Hajime Hirase, Maiken Nedergaard, Felix R.M. Beinlich
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103334- (2024)
Summary: Bioluminescence imaging (BLI) relies on the biochemical reaction between substrate and enzyme that triggers light emission upon convergence. Here, we present a protocol to study molecular oxygen dynamics in the in vivo mouse brain using the
Externí odkaz:
https://doaj.org/article/ecea92df0fb14292a408a014a94fc923
Autor:
Yusuke Nasu, Abhi Aggarwal, Giang N. T. Le, Camilla Trang Vo, Yuki Kambe, Xinxing Wang, Felix R. M. Beinlich, Ashley Bomin Lee, Tina R. Ram, Fangying Wang, Kelsea A. Gorzo, Yuki Kamijo, Marc Boisvert, Suguru Nishinami, Genki Kawamura, Takeaki Ozawa, Hirofumi Toda, Grant R. Gordon, Shaoyu Ge, Hajime Hirase, Maiken Nedergaard, Marie-Eve Paquet, Mikhail Drobizhev, Kaspar Podgorski, Robert E. Campbell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in mammals. However, investigations of the inter- and intra-cellular dynamics of l-lactate are currently hampered by the limited selection and performance of l-
Externí odkaz:
https://doaj.org/article/92c1078698bf4a70b5ef20a844149591
Autor:
Verena Untiet, Felix R. M. Beinlich, Peter Kusk, Ning Kang, Antonio Ladrón-de-Guevara, Wei Song, Celia Kjaerby, Mie Andersen, Natalie Hauglund, Zuzanna Bojarowska, Björn Sigurdsson, Saiyue Deng, Hajime Hirase, Nicolas C. Petersen, Alexei Verkhratsky, Maiken Nedergaard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Astrocytes act as a dynamic Cl− reservoir regulating Cl− homeostasis in the CNS. Astrocytic Cl− is high and stable during sleep, it is lower during wakefulness and fluctuates in response to sensory input and motor activity. Efflux of Cl− from
Externí odkaz:
https://doaj.org/article/38d2da81b87c466da2c47d8b24e79713
Autor:
Sheng-Yi Wu, Yurong Wen, Nelson B C Serre, Cathrine Charlotte Heiede Laursen, Andrea Grostøl Dietz, Brian R Taylor, Mikhail Drobizhev, Rosana S Molina, Abhi Aggarwal, Vladimir Rancic, Michael Becker, Klaus Ballanyi, Kaspar Podgorski, Hajime Hirase, Maiken Nedergaard, Matyáš Fendrych, M Joanne Lemieux, Daniel F Eberl, Alan R Kay, Robert E Campbell, Yi Shen
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001772 (2022)
Potassium ion (K+) plays a critical role as an essential electrolyte in all biological systems. Genetically-encoded fluorescent K+ biosensors are promising tools to further improve our understanding of K+-dependent processes under normal and patholog
Externí odkaz:
https://doaj.org/article/3acdec6eadb747dba6da2bd4ef33714b
Autor:
Hiromu Monai, Shinnosuke Koketsu, Yoshiaki Shinohara, Takatoshi Ueki, Peter Kusk, Natalie L. Hauglund, Andrew J. Samson, Maiken Nedergaard, Hajime Hirase
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cortical spreading depolarization (CSD) is a propagating wave of tissue depolarization characterized by a large increase of extracellular potassium concentration and prolonged subsequent electrical silencing of neurons. Waves of CSD arise sp
Externí odkaz:
https://doaj.org/article/c8a2b7c39e79416a9df5bd64aefd4976
Autor:
Hisako Sugimoto, Takuro Horii, Jun-Na Hirota, Yoshitake Sano, Yo Shinoda, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Hajime Hirase, Izuho Hatada, Teiichi Furuichi, Tetsushi Sadakata
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract The HapMap Project is a major international research effort to construct a resource to facilitate the discovery of relationships between human genetic variations and health and disease. The Ser19Stop single nucleotide polymorphism (SNP) of h
Externí odkaz:
https://doaj.org/article/a3dea4b032d6409185ddd1ede8e42850
Autor:
Yuki Oe, Xiaowen Wang, Tommaso Patriarchi, Ayumu Konno, Katsuya Ozawa, Kazuko Yahagi, Hirokazu Hirai, Takashi Tsuboi, Tetsuya Kitaguchi, Lin Tian, Thomas J. McHugh, Hajime Hirase
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Astrocytic GPCRs activate Ca2+ and cAMP signaling pathways, however, the in vivo dynamics of the two second messengers have not been fully been characterized. The authors demonstrate distinct noradrenaline-induced astrocytic Ca2+ and cAMP dynamics du
Externí odkaz:
https://doaj.org/article/de4152a6e93445c59df4faa68661c234
Autor:
Olivier Dubanet, Arnaldo Ferreira Gomes Da Silva, Andreas Frick, Hajime Hirase, Anna Beyeler, Xavier Leinekugel
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109381- (2021)
Summary: The hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, including epileptogenesis, is appealing but controversial because of the technical difficulty of probing endogenous GABAergic synaptic function in vi
Externí odkaz:
https://doaj.org/article/88e97c6d0ef1404b99912b8da57c2a88
Autor:
Hiromu Monai, Shinnosuke Koketsu, Yoshiaki Shinohara, Takatoshi Ueki, Peter Kusk, Natalie L. Hauglund, Andrew J. Samson, Maiken Nedergaard, Hajime Hirase
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/cda9f77eacd14f9f8ab9c09f64d278c1