Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Hajeung Park"'
Autor:
Yuka Otsuka, Eunjung Kim, Austin Krueger, Justin Shumate, Chao Wang, Bilel Bdiri, Sultan Ullah, HaJeung Park, Louis Scampavia, Thomas D. Bannister, Donghoon Chung, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 29, Iss 6, Pp 100180- (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for nearly 7 million deaths worldwide since its outbreak in late 2019. Even with the rapid development and production of vaccines and intensive research, there is still a hug
Externí odkaz:
https://doaj.org/article/bb6f58ce5e684354a6938ab8ae270651
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The vacuolar sorting receptors (VSRs) are specific to plants and are responsible for sorting and transporting particular proteins from the trans-Golgi network to the vacuole. This process is critically important for various cellular function
Externí odkaz:
https://doaj.org/article/c41dcb10c9eb47dcb2cd38d4e1a1b445
Autor:
Mai H. Tran, Hajeung Park, Christopher L. Nobles, Pabalu Karunadharma, Li Pan, Guocai Zhong, Haimin Wang, Wenhui He, Tianling Ou, Gogce Crynen, Kelly Sheptack, Ian Stiskin, Huihui Mou, Michael Farzan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 40-53 (2021)
CRISPR effector proteins introduce double-stranded breaks into the mammalian genome, facilitating gene editing by non-homologous end-joining or homology-directed repair. Unlike the more commonly studied Cas9, the CRISPR effector protein Cas12a/Cpf1 r
Externí odkaz:
https://doaj.org/article/528d54708b9d465fa463c4fbb4f6a469
Autor:
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/b1fd8e202dc64662880de54a651a8517
Autor:
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Publikováno v:
eLife, Vol 8 (2019)
Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeuti
Externí odkaz:
https://doaj.org/article/7598ee1869b74d83a7b3c7b8c0a9b36c
Autor:
Chao Wang, Juan Diez, Hajeung Park, Christoph Becker-Pauly, Gregg B. Fields, Timothy P. Spicer, Louis D. Scampavia, Dmitriy Minond, Thomas D. Bannister
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 197 (2021)
Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin α, or its close relati
Externí odkaz:
https://doaj.org/article/d8cceaa6cbc14f5f907dec89399d1671
Autor:
Simira Carothers, Rogers Nyamwihura, Jasmine Collins, Huaisheng Zhang, HaJeung Park, William N. Setzer, Ifedayo Victor Ogungbe
Publikováno v:
Molecules, Vol 23, Iss 2, p 355 (2018)
The Latin American plant Tabernaemontana longipes was studied in this work as a potential source of antiparasitic agents. The chloroform extract of T. longipes leaves was separated into several fractions, and tested for antitrypanosomal activity. One
Externí odkaz:
https://doaj.org/article/8d2e591851e545abae4ed9a2170597e4
Autor:
Karim Mersal, Mohammed S. Abdel-Maksoud, Eslam M.H. Ali, Usama M. Ammar, Seyed-Omar Zaraei, Md Mamunul Haque, Tanuza Das, Noha F. Hassan, Eunice EunKyeong Kim, Jun-Seok Lee, HaJeung Park, Kwan Hyi Lee, Mohammed I. El-Gamal, Hee-Kwon Kim, Chang-Hyun Oh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37a89818c3729603d1479bb6c2b1be5a
https://doi.org/10.2139/ssrn.4454234
https://doi.org/10.2139/ssrn.4454234
Autor:
Ji-Hak Jeong, Shangwei Zhong, Fuzhuo Li, Changhao Huang, Xueyan Chen, Qingqing Liu, Shoujiao Peng, HaJeung Park, You Mie Lee, Jasreman Dhillon, Jun-Li Luo
Publikováno v:
Journal of Experimental Medicine. 220
Androgen deprivation therapy (ADT) is a systemic therapy for advanced prostate cancer (PCa); although most patients initially respond to ADT, almost all cancers eventually develop castration-resistant PCa (CRPC). Currently, most research focuses on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf664cba3a7e48442541661e8f9cb01
https://doi.org/10.1084/jem.20211546
https://doi.org/10.1084/jem.20211546
Publikováno v:
ACS Med Chem Lett
[Image: see text] An indazole/aza-indazole scaffold was developed as a novel chemotype for JNK3 inhibition. Extensive structure activity relationship (SAR) studies utilizing various in vitro and in vivo assays led to potent and highly selective JNK3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1ed6f7cc06fbaceb5c1c9f8d5888f0
https://doi.org/10.1021/acsmedchemlett.1c00334
https://doi.org/10.1021/acsmedchemlett.1c00334