IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

Autor: Korneliusz Golebski, Xavier R. Ros, Maho Nagasawa, Sophie van Tol, Balthasar A. Heesters, Hajar Aglmous, Chantal M. A. Kradolfer, Medya M. Shikhagaie, Sven Seys, P. W. Hellings, Cornelis M. van Drunen, Wytske J. Fokkens, Hergen Spits, Suzanne M. Bal

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Innate lymphoid cells (ILCs) play critical immunological roles including immune surveillance at mucosal sites. Here the authors show that during nasal inflammation pathogen-induced cytokine production guides the differentiation of ILCs.

Externí odkaz: https://doaj.org/article/6ea86cb26d194858951641d2dc4ea3bd

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

Autor: Sven Seys, Maho Nagasawa, Suzanne M. Bal, Wytske Fokkens, Hajar Aglmous, Medya Shikhagaie, Xavier Romero Ros, Chantal M. A. Kradolfer, Balthasar A. Heesters, Korneliusz Golebski, P W Hellings, Cornelis M. van Drunen, Hergen Spits, Sophie van Tol

Publikováno v: Nature communications, 10(1):2162. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications

Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing and remodeling, features that are dysfunctional in patients with cystic fibrosis (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7acfd806a425fb9006dfaa24ffe78a
https://pure.amc.nl/en/publications/il1-il23-and-tgf-drive-plasticity-of-human-ilc2s-towards-il17producing-ilcs-in-nasal-inflammation(eff44bb0-b989-4d9f-8fb7-6abd65dad153).html