Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Haizi Zheng"'
Autor:
Yaping Liu, Sarah C. Reed, Christopher Lo, Atish D. Choudhury, Heather A. Parsons, Daniel G. Stover, Gavin Ha, Gregory Gydush, Justin Rhoades, Denisse Rotem, Samuel Freeman, David W. Katz, Ravi Bandaru, Haizi Zheng, Hailu Fu, Viktor A. Adalsteinsson, Manolis Kellis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Analysis of DNA methylation in cell-free DNA reveals clinically relevant biomarkers but requires specialized protocols such as whole-genome bisulfite sequencing. Meanwhile, millions of cell-free DNA samples are being profiled by whole-genome
Externí odkaz:
https://doaj.org/article/2651db1b0e8b4f7bb0bfb12f96123920
Autor:
Hailu Fu, Haizi Zheng, Xiaoting Chen, Matthew T. Weirauch, Louis J. Muglia, Li Wang, Yaping Liu
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Cis-regulatory elements are coordinated to regulate the expression of their targeted genes. However, the joint measurement of cis-regulatory elements’ activities and their interactions in spatial proximity is limited by the current sequenc
Externí odkaz:
https://doaj.org/article/52b3c226b97f4a43a7f7a6d0e0f0cf5f
Autor:
Xionghui Zhou, Haizi Zheng, Hailu Fu, Kelsey L. Dillehay McKillip, Susan M. Pinney, Yaping Liu
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract The fine-scale cell-free DNA fragmentation patterns in early-stage cancers are poorly understood. We developed a de novo approach to characterize the cell-free DNA fragmentation hotspots from plasma whole-genome sequencing. Hotspots are enri
Externí odkaz:
https://doaj.org/article/9ca69ea715234f7eacc84e879ec4296c
Autor:
Yaping Liu, Reed, Sarah C., Christopher Lo, Choudhury, Atish D., Parsons, Heather A., Stover, Daniel G., Ha, Gavin, Gydush, Gregory, Rhoades, Justin, Rotem, Denisse, Freeman, Samuel, Katz, David W., Bandaru, Ravi, Haizi Zheng, Hailu Fu, Adalsteinsson, Viktor A., Kellis, Manolis
Publikováno v:
Nature Communications; 3/30/2024, Vol. 15 Issue 1, p1-9, 9p, 1 Diagram, 3 Graphs
Autor:
Zaili Luo, Mingyang Xia, Wei Shi, Chuntao Zhao, Jiajia Wang, Dazhuan Xin, Xinran Dong, Yu Xiong, Feng Zhang, Kalen Berry, Sean Ogurek, Xuezhao Liu, Rohit Rao, Rui Xing, Lai Man Natalie Wu, Siying Cui, Lingli Xu, Yifeng Lin, Wenkun Ma, Shuaiwei Tian, Qi Xie, Li Zhang, Mei Xin, Xiaotao Wang, Feng Yue, Haizi Zheng, Yaping Liu, Charles B. Stevenson, Peter de Blank, John P. Perentesis, Richard J. Gilbertson, Hao Li, Jie Ma, Wenhao Zhou, Michael D. Taylor, Q. Richard Lu
Publikováno v:
Nature. 612(7941)
Medulloblastoma (MB) is the most common malignant childhood brain tumor1,2, yet the origin of the most aggressive subgroup-3 form remains elusive, impeding development of effective targeted treatments. Previous analyses of mouse cerebella3,4or human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdd6db2b3d80de588bcb34d5acc7d19
https://pubmed.ncbi.nlm.nih.gov/36450980
https://pubmed.ncbi.nlm.nih.gov/36450980
Autor:
Hailu Fu, Haizi Zheng, Xiaoting Chen, Matthew T. Weirauch, Louis J. Muglia, Li Wang, Yaping Liu
Cis-regulatory elements coordinate the regulation of their targeted genes’ expression. However, the joint measurement of cis-regulatory elements’ activities and their interactions in spatial proximity is limited by the current sequencing approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22254f57a33134943b0b93b834c3c742
https://doi.org/10.1101/2022.03.29.486102
https://doi.org/10.1101/2022.03.29.486102
Autor:
Xionghui Zhou, Haizi Zheng, Hailu Fu, Kelsey L. Dillehay McKillip, Susan M. Pinney, Yaping Liu
Publikováno v:
Genome medicine. 14(1)
The fine-scale cell-free DNA fragmentation patterns in early-stage cancers are poorly understood. We developed a de novo approach to characterize the cell-free DNA fragmentation hotspots from plasma whole-genome sequencing. Hotspots are enriched in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d361d5bfd28dfbe5a82180743e7afc
https://pubmed.ncbi.nlm.nih.gov/36482487
https://pubmed.ncbi.nlm.nih.gov/36482487
Publikováno v:
Cancer Research. 82:5797-5797
Cis-regulatory elements (CREs) play instrumental roles in the regulation of mammalian gene expression. Sets of transcriptional factors bring together multiple CREs, which can be up to megabases away, to initiate and maintain the gene expression. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59681039ea1cdb0318afb69b0b657c5a
https://doi.org/10.1158/1538-7445.am2022-5797
https://doi.org/10.1158/1538-7445.am2022-5797
Publikováno v:
Bioinformatics
SummaryCirculating cell-free DNA (cfDNA) is a promising biomarker for the diagnosis and prognosis of many diseases, including cancer. The genome-wide non-random fragmentation patterns of cfDNA are associated with the nucleosomal protection, epigeneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef21ad3ce9af1e119e7af0f396f169bb
https://doi.org/10.1101/2020.08.18.255885
https://doi.org/10.1101/2020.08.18.255885
Autor:
Xionghui Zhou, Haizi Zheng, Hailu Fu, Kelsey L. Dillehay McKillip, Susan M. Pinney, Yaping Liu
The global variation of cell-free DNA fragmentation patterns is a promising biomarker for cancer diagnosis. However, the characterization of its hotspots and aberrations in early-stage cancer at the fine-scale is still poorly understood. Here, we dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5a1271d34c80df543694d2d3ff2f82
https://doi.org/10.1101/2020.07.16.201350
https://doi.org/10.1101/2020.07.16.201350