Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease

Autor: Rabal, Obdulia, Sánchez-Arias, Juan A., Cuadrado-Tejedor, Mar, de Miguel, Irene, Pérez-González, Marta, García-Barroso, Carolina, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Sáez, Elena, Espelosin, Maria, Ursua, Susana, Haizhong, Tan, Wei, Wu, Musheng, Xu, Garcia-Osta, Ana, Oyarzabal, Julen

Publikováno v: In European Journal of Medicinal Chemistry 25 April 2018 150:506-524

Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead

Autor: Haizhong Tan, M. Belzunce, Josune Orbe, Juan A. Sánchez-Arias, Wei Wu, Ana Ugarte, Musheng Xu, Jose A. Rodriguez, Agustina Salicio, Hongyu Ma, José A. Páramo, Obdulia Rabal, Julen Oyarzabal

Publikováno v: Journal of Medicinal Chemistry. 58:2465-2488

Growing evidence suggests that matrix metalloproteinases (MMP) are involved in thrombus dissolution; then, considering that new therapeutic strategies are required for controlling hemorrhage, we hypothesized that MMP inhibition may reduce bleeding by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92beafb59762595de1ce8494431b507f
https://doi.org/10.1021/jm501940y

Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives

Autor: Haizhong Tan, Zheng-Ming Li, Jian-Guo Wang, Luke W. Guddat, Yi Ma, Yong-Hong Li

Publikováno v: Journal of agricultural and food chemistry. 59(18)

Acetohydroxyacid synthase (AHAS) catalyzes the first common step in the biosynthesis of the branched-chain amino acids. As a result of its metabolic importance in plants, it is a target for many commercial herbicides. Virtual screening analysis inspi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bbf425974a57d25f7ee3e5c99c00f8
https://pubmed.ncbi.nlm.nih.gov/21838297

Chemical Synthesis, in Vitro Acetohydroxyacid Synthase (AHAS) Inhibition, Herbicidal Activity, and Computational Studies of Isatin Derivatives.

Autor: Jianguo Wang, Haizhong Tan, Yonghong Li, Yi Ma, Zhengming Li, Guddat, Luke W.

Publikováno v: Journal of Agricultural & Food Chemistry; 9/28/2011, Vol. 59 Issue 18, p9892-9900, 9p

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

Autor: Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M; Anatomy Department, School of Medicine, University of Navarra , Irunlarrea 1, E-31008 Pamplona, Spain., de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T; WuXi Apptec (Tianjin) Co. Ltd., TEDA, No. 111 HuangHai Road, Fourth Avenue, Tianjin 300456, PR China., Wei W; WuXi Apptec (Tianjin) Co. Ltd., TEDA, No. 111 HuangHai Road, Fourth Avenue, Tianjin 300456, PR China., Musheng X; WuXi Apptec (Tianjin) Co. Ltd., TEDA, No. 111 HuangHai Road, Fourth Avenue, Tianjin 300456, PR China., Garcia-Osta A, Oyarzabal J

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Oct 13; Vol. 59 (19), pp. 8967-9004. Date of Electronic Publication: 2016 Sep 27.