Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Haiyang Zhong"'
Autor:
Haiyang Zhong, Zhengshuo Zhang, Mengdan Chen, Yue Chen, Can Yang, Yunsheng Xue, Pei Xu, Hongli Liu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10477 (2024)
c-Src is involved in multiple signaling pathways and serves as a critical target in various cancers. Growing evidence suggests that prolonging a drug’s residence time (RT) can enhance its efficacy and selectivity. Thus, the development of c-Src ant
Externí odkaz:
https://doaj.org/article/7fe95273914f43249e9ac8657c860a94
Publikováno v:
Photonics, Vol 11, Iss 1, p 20 (2023)
A partially coherent off-axis double vortex beam (PCOADVB) composed of two off-axis vortices is theoretically presented. The analytical equations of a PCOADVB in oceanic turbulence are presented, and the intensity profiles and the number of coherence
Externí odkaz:
https://doaj.org/article/6ca430e34bcb43b0a00e5cd339b42f07
Autor:
Chao Shen, Xueping Hu, Junbo Gao, Xujun Zhang, Haiyang Zhong, Zhe Wang, Lei Xu, Yu Kang, Dongsheng Cao, Tingjun Hou
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-18 (2021)
Abstract Structure-based drug design depends on the detailed knowledge of the three-dimensional (3D) structures of protein–ligand binding complexes, but accurate prediction of ligand-binding poses is still a major challenge for molecular docking du
Externí odkaz:
https://doaj.org/article/205641c22c1c450e88347fe89febb7c7
Publikováno v:
Photonics, Vol 10, Iss 5, p 551 (2023)
The descriptions of a radially phased-locked Hermite–Gaussian correlated beam array are introduced, the equation of this beam array in oceanic turbulence is derived, and the intensity profiles of this beam array are shown and analyzed. The results
Externí odkaz:
https://doaj.org/article/6db42f4e8a6847f4b81ef9f78b4b8675
Autor:
Fengling Wang, Wenling Ye, Shuang Wang, Yongxing He, Haiyang Zhong, Yuwei Wang, Yongchang Zhu, Jianting Han, Zhitong Bing, Shaoping Ji, Huanxiang Liu, Xiaojun Yao
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 3, Pp 281-293 (2021)
Blockade of the PD-1/PD-L1 immunologic checkpoint using monoclonal antibodies has provided breakthrough therapies against cancer in the recent years. Nevertheless, intrinsic disadvantages of therapeutic antibodies may limit their applications. Thus,
Externí odkaz:
https://doaj.org/article/8ccac2f9f518430f951d7e8eabfbcca6
Autor:
Fengling Wang, Wenling Ye, Yongxing He, Haiyang Zhong, Yongchang Zhu, Jianting Han, Xiaoqing Gong, Yanan Tian, Yuwei Wang, Shuang Wang, Shaoping Ji, Huanxiang Liu, Xiaojun Yao
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3971 (2023)
Targeting of the PD-1/PD-L1 immunologic checkpoint is believed to have provided a real breakthrough in the field of cancer therapy in recent years. Due to the intrinsic limitations of antibodies, the discovery of small-molecule inhibitors blocking PD
Externí odkaz:
https://doaj.org/article/36e5db608e47448b8a13aa74b66eba05
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2399 (2022)
The formation of neurofibrillary tangles (NFT) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein Tau is a hallmark of tauopathies, including Alzheimer’s Disease. It has been reported that acetyl
Externí odkaz:
https://doaj.org/article/405adf32f1f24cf0b9bcd39f168ff33b
Publikováno v:
Photonics, Vol 8, Iss 1, p 5 (2020)
The theoretical descriptions for a radial phase-locked multi-Gaussian Schell-model vortex (RPLMGSMV) beam array is first given. The normalized intensity and coherence distributions of a RPLMGSMV beam array propagating in free space and atmospheric tu
Externí odkaz:
https://doaj.org/article/f27a91759c544a2db3bd59ed537d8ac0
Publikováno v:
Applied Sciences, Vol 10, Iss 2, p 450 (2020)
In this paper, rectangular multi-Gaussian Schell-model (MGSM) array beams, which consists N×D beams in rectangular symmetry, are first introduced. The analytical expressions of MGSM array beams propagating through free space and non-Kolmogorov turbu
Externí odkaz:
https://doaj.org/article/e65edc4f00984b4d94980661e2db25b8
Publikováno v:
Current Medicinal Chemistry. 30
Tau dysfunction has a close association with many neurodegenerative diseases, which are collectively referred to as tauopathies. Neurofibrillary tangles (NFTs) formed by misfolding and aggregation of tau are the main pathological process of tauopathy