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Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B gene

Autor: Ogawara, K, Kuldo, JM, Oosterhuis, K, Kroesen, BJ, Rots, MG, Trautwein, C, Kimura, T, Haisma, HJ, Molema, G

Publikováno v: Arthritis Research and Therapy, 8(1):32. BioMed Central Ltd.

In order to selectively block nuclear factor kappa B (NF-kappa B)-dependent signal transduction in angiogenic endothelial cells, we constructed an alpha v beta 3 integrin specific adenovirus encoding dominant negative I kappa B (dnI kappa B) as a the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::1fb24cc660378ae179811082b9cd3a10
https://research.rug.nl/en/publications/77dcdbe0-1d0b-487e-96c3-f53690fb59bc

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A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity

Autor: Kirby, TO, Rivera, A, Rein, D, Ulasov, [No Value], Breidenbach, M, Kataram, M, Contreras, JL, Krumdieck, C, Yamamoto, M, Rots, MG, Haisma, HJ, Alvarez, RD, Mahasreshti, PJ, Curiel, DT

Publikováno v: Clin.Cancer Res., 10(24), 8697-8703. AMER ASSOC CANCER RESEARCH

Purpose: Current animal tumor models are inadequate for the evaluation of toxicity and efficacy of conditionally replicative adenoviruses. A novel model system is needed that will provide insight into the anticipated therapeutic index of conditionall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::c5a52b312b327a03f1a908dbc4a68c1b
https://research.rug.nl/en/publications/b61a0854-fffb-4d98-b08e-8dba147b877c

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State of the art in gene therapy

Autor: Haisma, HJ, Rots, MG, Sibinga, CTS, DeLeij, LFM

Publikováno v: CELLULAR ENGINEERING AND CELLULAR THERAPIES, 171-187
STARTPAGE=171;ENDPAGE=187;TITLE=CELLULAR ENGINEERING AND CELLULAR THERAPIES

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e4ff1a165d6dcb1b011d0f25b830b456
https://research.rug.nl/en/publications/579c68a2-4491-4110-906f-123f55ed6ee1

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Epidermal growth factor receptor targeting of replication competent adenovirus enhances cytotoxicity in bladder cancer

Autor: van der Poel, HG, Molenaar, B, van Beusechem, VW, Haisma, HJ, Rodriguez, R, Curiel, DT, Gerritsen, WR

Publikováno v: Journal of Urology, 168(1), 266-272. LIPPINCOTT WILLIAMS & WILKINS

Purpose: We evaluated the delivery and oncolytic potential of targeted replication competent adenoviruses in bladder cancer lines. Materials and Methods: Seven established human bladder cancer tumor lines (5637, SW800, TCCsup, J82, Scaber, T24 and 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::67cd03a701272a48b855d51e4e8dd602
https://research.rug.nl/en/publications/a0a95b79-33a3-4694-bde6-90ade6aeca80

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A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug

Autor: Boven, E, Oosterhoff, D, van der Meulen-Muileman, IH, Huls, GA, Gerritsen, WR, Haisma, HJ, Pinedo, HM

Publikováno v: British Jounal of Cancer, 86(5), 811-818. Nature Publishing Group

Monoclonal antibodies against tumour-associated antigens could be useful to deliver enzymes selectively to the site of a tumour for activation of a non-toxic prodrug. A completely human fusion protein may be advantageous for repeated administration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::904b86d429f55ed0d165ef9aaf138882
https://research.rug.nl/en/publications/55e537de-7577-4e25-9a2c-bafda0114468

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Cloning and characterization of human liver cytosolic beta-glycosidase

Autor: De Graaf, M, Van Veen, IC, Van Der Meulen-Muileman, IH, Gerritsen, WR, Pinedo, HM, Haisma, HJ

Publikováno v: Biochemical Journal, 356, 907-910. PORTLAND PRESS LTD

Cytosolic beta -glucosidase (EC 3.2.1.21) from mammalian liver is a member of the family 1 glycoside hydrolases and is known for its ability to hydrolyse a range of beta -D-glycosides. including beta -D-glucoside acid beta -D-galactoside. We therefor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cff6fa029fef045884e6eb22b2cf5ab0
https://research.rug.nl/en/publications/58d9997b-44d3-4f96-b663-ad4ec6c8871b

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Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts

Autor: Houba, PHJ, Boven, E, van der Meulen-Muileman, IH, Leenders, RGG, Scheeren, JW, Pinedo, HM, Haisma, HJ

Publikováno v: Biochemical Pharmacology, 57(6), 673-680. PERGAMON-ELSEVIER SCIENCE LTD

N-[4-daunorubicin-N-carbonyl (oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) is a glucuronide prodrug of daunorubicin (DNR) which induced a better tumor growth delay than DNR when studied at equitoxic doses in three human ovarian cancer xeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2c5f2fa49a976a663323af5fed372aa2
https://research.rug.nl/en/publications/d8a0a738-c166-4221-a1ac-7b391eab5156

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Construction and characterization of a fusion protein of single-chain anti-CD20 antibody and human beta-glucuronidase for antibody-directed enzyme prodrug therapy

Autor: Haisma, HJ, Sernee, MF, Hooijberg, E, Brakenhoff, RH, van den Meulen-Mulleman, IH, Pinedo, HM, Boven, E

Publikováno v: Blood, 92(1), 184-190. AMER SOC HEMATOLOGY

The CD20 antigen is an attractive target for specific treatment of B-cell lymphoma. Antibody-directed enzyme prodrug therapy (ADEPT) aims at the specific activation of a nontoxic prodrug at the tumor site by an enzyme targeted by a tumor-specific ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dc70bfa08336e9b388091346dba2ab12
https://research.rug.nl/en/publications/6af8ca63-d1c0-4e7c-9db4-bde6642550d1

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