Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Haiqing Xiong"'
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Single-cell multiomics (sc-multiomics) is a burgeoning field that simultaneously integrates multiple layers of molecular information, enabling the characterization of dynamic cell states and activities in development and disease as well as treatment
Externí odkaz:
https://doaj.org/article/83ca3cb2fcb04bb0bb8f5a669a44c3dd
Autor:
Jiejie Zhang, Chen C. Li, Xin Li, Yaxi Liu, Qianhao Wang, Guangyu Zhang, Haiqing Xiong, Aibin He, Shanshan Ai
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106509- (2023)
Summary: Cell type-specific expression of the developmental gene is conferred by distinct enhancer elements. Current knowledge about mechanisms in Nkx2-5 transcriptional regulation and its specific roles in multistage heart morphogenesis is limited.
Externí odkaz:
https://doaj.org/article/ffa7f41e72ac4b4598ea7f541140ad40
Autor:
Rui Li, Xianyou Xia, Xing Wang, Xiaoyu Sun, Zhongye Dai, Dawei Huo, Huimin Zheng, Haiqing Xiong, Aibin He, Xudong Wu
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000749 (2020)
Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) 9 has been widely used far beyond genome editing. Fusions of deactivated Cas9 (dCas9) to transcription effectors enable interrogation of the epigenome and contr
Externí odkaz:
https://doaj.org/article/7e815987665245238c896b06c9fe0f08
Autor:
Haiqing Xiong1 xionghaiqing@ihcams.ac.cn, Qianhao Wang2, Li, Chen C.2, He, Aibin2,3 ahe@pku.edu.cn
Publikováno v:
Science Advances. 1/5/2024, Vol. 10 Issue 1, p1-15. 15p.
Sculpting the epigenome with a combination of histone modifications and transcription factor (TF) occupancy determines gene transcription and cell fate specification. Here we first develop uCoTarget, utilizing a split-pool barcoding strategy for real
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4a25c939ee173f8a30dccb36fddd5e0
https://doi.org/10.1101/2023.04.04.535478
https://doi.org/10.1101/2023.04.04.535478
Publikováno v:
The Analyst. 147:5300-5305
Based on the ClO−-triggered chlorination reaction and the subsequent pKa decrease, a two-photon ratiometric ClO− fluorescent probe was designed.
Publikováno v:
The Analyst. 147(23)
Based on the selective ClO
Publikováno v:
Nature Methods. 18:652-660
Deciphering mechanisms in cell-fate decisions requires single-cell holistic reconstructions of multidimensional epigenomic states in transcriptional regulation. Here we develop CoTECH, a combinatorial barcoding method allowing high-throughput single-
Autor:
Benhua Wang, Zhaoguang Yang, Haiqing Xiong, Xiangzhi Song, Hongyan Zhang, Haipu Li, Jingpei Wang, Long He, Yun Zhang
Publikováno v:
Analytical Chemistry. 92:11029-11034
By introducing the tetrahydroquinoxaline group as the electron donor to enhance intramolecular charge transfer effect, we deliberately designed a coumarin derivative, TQC-HClO, to serve as a two-photon ratiometric fluorescent probe for imaging hypoch
Autor:
Benhua Wang, Xiangzhi Song, Jingpei Wang, Wei Wang, Xingjiang Liu, Jinliang Han, Haiqing Xiong
Publikováno v:
Analytical Chemistry. 92:5134-5142
As two important reactive oxygen species, hydrogen peroxide (H2O2) and hypochlorous acid (HClO) play vital roles in many physiological and pathological processes. However, the relationship between these two species is seldom investigated, in part, be