Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Haiqi, Chen"'
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTBackground: Although multiple myeloma is still incurable, an abundance of novel treatments have become available for relapsed and or refractory multiple myeloma (RRMM). Direct head-to-head comparisons between the novel treatments are lacking.
Externí odkaz:
https://doaj.org/article/6775c56274aa4253b278a2df044eb262
Autor:
Shreya Rajachandran, Xin Zhang, Qiqi Cao, Andre L. Caldeira-Brant, Xiangfan Zhang, Youngmin Song, Melanie Evans, Orhan Bukulmez, Edward J. Grow, Makoto Nagano, Kyle E. Orwig, Haiqi Chen
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112737- (2023)
Summary: Spermatogonial stem cells (SSCs) in the testis support the lifelong production of sperm. SSCs reside within specialized microenvironments called “niches,” which are essential for SSC self-renewal and differentiation. However, our underst
Externí odkaz:
https://doaj.org/article/f3375dcdc9284a48b949b1ec48933b23
Autor:
Jamie L. Marshall, Teia Noel, Qingbo S. Wang, Haiqi Chen, Evan Murray, Ayshwarya Subramanian, Katherine A. Vernon, Silvana Bazua-Valenti, Katie Liguori, Keith Keller, Robert R. Stickels, Breanna McBean, Rowan M. Heneghan, Astrid Weins, Evan Z. Macosko, Fei Chen, Anna Greka
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104097- (2022)
Summary: High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored. We appl
Externí odkaz:
https://doaj.org/article/d6f6c8d314e2467b847da7b75df23eaa
Autor:
Zhaoyang Huang, Rong Luo, Liu Yang, Haiqi Chen, Xinyao Zhang, Jiawen Han, Hongxia Wang, Zhongyang Zhou, Zhao Wang, Lan Shao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The overproduction of osteoclasts, leading to bone destruction in patients with rheumatoid arthritis (RA), is well established. However, little is known about the metabolic dysfunction of osteoclast precursors (OCPs) in RA. Herein, we show that incre
Externí odkaz:
https://doaj.org/article/e38223f3590f4c9694f57f91f52cff2b
Autor:
Haiqi Chen, Evan Murray, Anubhav Sinha, Anisha Laumas, Jilong Li, Daniel Lesman, Xichen Nie, Jim Hotaling, Jingtao Guo, Bradley R. Cairns, Evan Z. Macosko, C. Yan Cheng, Fei Chen
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109915- (2021)
Summary: Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs governing mammalian spermatogenesis but fails to delineate their dynamics in the native context of seminiferous tubules, the spatially confined functional
Externí odkaz:
https://doaj.org/article/a14b6b9f7c6f49fcbea7513571e4a8d5
Autor:
Lan Shao, Bin Huang, Xinyao Zhang, Zongren Wang, Xueling Zhang, Wuguo Li, Qiao Su, Zhaoyang Huang, Haiqi Chen, Chengqiang Mo, Wei Ou, Junxing Chen, Guangyin Zhao, Lingwu Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background The efficacy of docetaxel-based chemotherapy is limited by the development of drug resistance. Recent studies demonstrated the efficacy of anti-programmed death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) immunotherapies in metastatic
Externí odkaz:
https://doaj.org/article/b6463c76b193417e8977fbfa84820fea
Autor:
Sarah M. Mangiameli, Haiqi Chen, Andrew S. Earl, Julie A. Dobkin, Daniel Lesman, Jason D. Buenrostro, Fei Chen
Publikováno v:
Nature Methods. 20:686-694
Autor:
Christopher L. Robinson, Angie C. N. Chong, Alison W. Ashbrook, Ginnie Jeng, Julia Jin, Haiqi Chen, Elizabeth I. Tang, Laura A. Martin, Rosa S. Kim, Reyn M. Kenyon, Eileen Do, Joseph M. Luna, Mohsan Saeed, Lori Zeltser, Harold Ralph, Vanessa L. Dudley, Marc Goldstein, Charles M. Rice, C. Yan Cheng, Marco Seandel, Shuibing Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with d
Externí odkaz:
https://doaj.org/article/de04bd349fab404aa0fe17716eae5931
Autor:
Dylan M. Cable, Evan Murray, Vignesh Shanmugam, Simon Zhang, Luli S. Zou, Michael Diao, Haiqi Chen, Evan Z. Macosko, Rafael A. Irizarry, Fei Chen
Publikováno v:
Nature Methods. 19:1076-1087
A central problem in spatial transcriptomics is detecting differentially expressed (DE) genes within cell types across tissue context. Challenges to learning DE include changing cell type composition across space and measurement pixels detecting tran
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to
Externí odkaz:
https://doaj.org/article/2c87f32c908144ffae74b5ab504711f7