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A Novel Multi-Dimensional Analysis of Rodent Gait Reveals the Compensation Strategies Used during Spontaneous Recovery from Spinal Cord and Traumatic Brain Injury

Autor: Nathan D. Neckel, Mark P. Burns, Haining Dai

Publikováno v: J Neurotrauma

As rodent locomotion becomes a more popular behavioral assay, proper rodent gait analysis becomes more and more important. Gait measures, such as stride length, cycle time, and duty factor, are not independent of one another, making statistical compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f46c7964e4aad6a8bbdd44fa96b3218
https://doi.org/10.1089/neu.2018.5959

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Opiate-Free Pain Therapy Using Carbamazepine-Loaded Microparticles Provides Up to 2 Weeks of Pain Relief in a Neuropathic Pain Model

Autor: Amer Khalil, Dana M. Tilley, Francis M. Reynolds, Katrin Holzhaus, Neel Mehta, Chris Doherty, Greici Mercedes, Haining Dai, Amitabh Gulati

Publikováno v: Pain Practice. 18:1024-1035

INTRODUCTION Opioids remain a mainstay in the treatment of acute and chronic pain, despite numerous and potentially dangerous side effects. There is a great unmet medical need for alternative treatments for patients suffering from pain that do not re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08d400e6ca30d0ba8f2291ecab0fa46
https://doi.org/10.1111/papr.12705

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Skilled reach training enhances robotic gait training to restore overground locomotion following spinal cord injury in rats

Autor: Nathan D. Neckel, Olga Rodriguez, Yichien Lee, Christopher Albanese, Haining Dai, John Hanckel

Publikováno v: Behav Brain Res

Rehabilitative training has been shown to improve motor function following spinal cord injury (SCI). Unfortunately, these gains are primarily task specific; where reach training only improves reaching, step training only improves stepping and stand t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90b751b539e71659a25a9a4d334e912
https://doi.org/10.1016/j.bbr.2021.113490

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Viscous field training induces after effects but hinders recovery of overground locomotion following spinal cord injury in rats

Autor: Haining Dai, Nathan D. Neckel

Publikováno v: Behav Brain Res

Robotic-assisted gait training was able to improve the unassisted overground locomotion of rats following a cervical spinal cord injury. Specifically, four weeks of daily step training in the Robomedica Rodent Robotic Motor Performance System, where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3629ceffab0c0871d33f319a61b66a
https://doi.org/10.1016/j.bbr.2021.113415

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Addition of forelimb training reduces gains from robotic gait training in a rat model of spinal cord injury

Autor: Olga Rodriguez, Nathan D. Neckel, Haining Dai

Publikováno v: ICORR

To restore locomotor function following spinal cord injury the disrupted descending supraspinal drive needs to be re-connected to regions caudal to the injury. Robotic gait training aims to facilitate recovery by stimulating the proprioceptive networ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ba8e067aba048a856987e24762cbb2
https://pubmed.ncbi.nlm.nih.gov/28813843

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Labeling of dendritic spines with the carbocyanine dye DiI for confocal microscopic imaging in lightly fixed cortical slices

Autor: Byung Gon Kim, Marietta McAtee, Haining Dai, Stefano Vicini, Barbara S. Bregman

Publikováno v: Journal of Neuroscience Methods. 162:237-243

Visualization of dendritic spines is an important tool for researches on structural synaptic plasticity. Fluorescent labeling of the dendrites and spines followed by confocal microscopy permits imaging a large population of dendritic spines with a hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc56e26889f71b4fc180c271ef72403f
https://doi.org/10.1016/j.jneumeth.2007.01.016

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Remodeling of synaptic structures in the motor cortex following spinal cord injury

Autor: Marietta McAtee, Stefano Vicini, Byung Gon Kim, Barbara S. Bregman, Haining Dai

Publikováno v: Experimental Neurology. 198:401-415

After spinal cord injury (SCI), structural reorganization occurs at multiple levels of the motor system including the motor cortex, and this remodeling may underlie recovery of motor function. The present study determined whether SCI leads to a remod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf77756cc8f473579cb38b3b217b405
https://doi.org/10.1016/j.expneurol.2005.12.010

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Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury

Autor: Barbara S. Bregman, Ken Ishii, Masaya Nakamura, Hideyuki Okano, Haining Dai, Tom Finn, Yoshiaki Toyama

Publikováno v: Journal of Neuroscience Research. 84:1669-1681

Transplantation of neural stem cells (NSC) into lesioned spinal cord offers the potential to increase regeneration by replacing lost neurons or oligodendrocytes. The majority of transplanted NSC, however, typically differentiate into astrocytes that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5a4d5b89204342523a0c3a933af540
https://doi.org/10.1002/jnr.21079

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MICAL flavoprotein monooxygenases: Expression during neural development and following spinal cord injuries in the rat

Autor: Barbara S. Bregman, Jonathan R. Terman, Byung Gon Kim, Haining Dai, R. Jeroen Pasterkamp, Phillip G. Popovich, Alex L. Kolodkin, Karl J. Wahlin

Publikováno v: Molecular and Cellular Neuroscience. 31:52-69

MICALs comprise of a family of phylogenetically conserved, multidomain cytosolic flavoprotein monooxygenases. Drosophila (D-)MICAL binds the neuronal Sema1a receptor PlexA, and D-MICAL-PlexA interactions are required in vivo for Sema1a-induced axon r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece4761bbbd06ec4be0dcb8a7df729f8
https://doi.org/10.1016/j.mcn.2005.09.001

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