Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Hainan Lang"'
Autor:
Jennifer Y. Cho, Jeffrey A. Rumschlag, Evgeny Tsvetkov, Divya S. Proper, Hainan Lang, Stefano Berto, Ahlem Assali, Christopher W. Cowan
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 2, Pp 100289- (2024)
Background: Heterozygous mutations or deletions of MEF2C cause a neurodevelopmental disorder termed MEF2C haploinsufficiency syndrome (MCHS), characterized by autism spectrum disorder and neurological symptoms. In mice, global Mef2c heterozygosity ha
Externí odkaz:
https://doaj.org/article/5800355a599b4900a683921f4bd020f8
Autor:
LaShardai N. Brown, Jeremy L. Barth, Shabih Jafri, Jeffrey A. Rumschlag, Tyreek R. Jenkins, Carl Atkinson, Hainan Lang
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Sensorineural hearing loss is associated with dysfunction of cochlear cells. Although immune cells play a critical role in maintaining the inner ear microenvironment, the precise immune-related molecular mechanisms underlying the pathophysiology of h
Externí odkaz:
https://doaj.org/article/c4424cefe6774df4a7e409979519b270
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Age-related hearing loss is a chronic degenerative disorder affecting one in two individuals above the age of 75. Current population projections predict a steady climb in the number of older individuals making the search for interventions to prevent
Externí odkaz:
https://doaj.org/article/7056d896c396435ebad7e5c8c696cdce
Autor:
Kenyaria V. Noble, Michelle L. Reyzer, Jeremy L. Barth, Hayes McDonald, Michael Tuck, Kevin L. Schey, Edward L. Krug, Hainan Lang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Exposure to noise or ototoxic agents can result in degeneration of cells in the sensory epithelium and auditory nerve, as well as non-sensory cells of the cochlear lateral wall. However, the molecular mechanisms underlying this pathology remain uncle
Externí odkaz:
https://doaj.org/article/9eb865eabfad4e778317c0d8e780712c
Autor:
LaShardai N. Brown, Yazhi Xing, Kenyaria V. Noble, Jeremy L. Barth, Clarisse H. Panganiban, Nancy M. Smythe, Mary C. Bridges, Juhong Zhu, Hainan Lang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Hearing relies on the transmission of auditory information from sensory hair cells (HCs) to the brain through the auditory nerve. This relay of information requires HCs to be innervated by spiral ganglion neurons (SGNs) in an exclusive manner and SGN
Externí odkaz:
https://doaj.org/article/6d71ac377bc044cf9e7e0e1d3c61f618
Autor:
Xinping Hao, Yazhi Xing, Michael W Moore, Jianning Zhang, Demin Han, Bradley A Schulte, Judy R Dubno, Hainan Lang
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97389 (2014)
Age-related hearing loss (presbycusis) is a common human disorder, affecting one in three Americans aged 60 and over. Previous studies have shown that presbyacusis is associated with a loss of non-sensory cells in the cochlear lateral wall. Sox10 is
Externí odkaz:
https://doaj.org/article/2837955fca014ddaabd0c7d62c0d38d7
Autor:
Yazhi Xing, Devadoss J Samuvel, Shawn M Stevens, Judy R Dubno, Bradley A Schulte, Hainan Lang
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34500 (2012)
Age-related hearing loss (presbyacusis) is the most common type of hearing impairment. One of the most consistent pathological changes seen in presbyacusis is the loss of spiral ganglion neurons (SGNs). Defining the cellular and molecular basis of SG
Externí odkaz:
https://doaj.org/article/e2372c69078b46d6a4fdec74de2216c2
Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans
Autor:
Jeffrey A. Rumschlag, Carolyn M. McClaskey, James W. Dias, Lilyana B. Kerouac, Kenyaria V. Noble, Clarisse Panganiban, Hainan Lang, Kelly C. Harris
Publikováno v:
Neurobiol Aging
Aging is associated with auditory nerve (AN) functional deficits and decreased inhibition in the central auditory system, amplifying central responses in a process referred to here as central gain. Although central gain increases response amplitudes,
Autor:
Brown, LaShardai N., Barth, Jeremy L., Jafri, Shabih, Rumschlag, Jeffrey A., Jenkins, Tyreek R., Atkinson, Carl, Hainan Lang
Publikováno v:
Frontiers in Neurology; 2023, p1-16, 16p
Autor:
Clarisse H. Panganiban, Jeremy L. Barth, Junying Tan, Kenyaria V. Noble, Carolyn M. McClaskey, Blake A. Howard, Shabih H. Jafri, James W. Dias, Kelly C. Harris, Hainan Lang
Publikováno v:
Glia
The auditory nerve (AN) of the inner ear is the primary conveyor of acoustic information from sensory hair cells to the brainstem. Approximately 95% of peripheral AN fibers are myelinated by glial cells. The integrity of myelin and the glial-associat