Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Haimanti Dorai"'
Autor:
Haimanti Dorai, Kevin D. Smith, Neil Templeton, Steven E. Lang, Michael J. Betenbaugh, Jamey D. Young, Allison G. McAtee-Pereira
Publikováno v:
Metabolic Engineering. 43:218-225
Industrial bioprocesses place high demands on the energy metabolism of host cells to meet biosynthetic requirements for maximal protein expression. Identifying metabolic phenotypes that promote high expression is therefore a major goal of the biotech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8321ada73fbbff1891cc46dc787b2031
https://doi.org/10.1016/j.ymben.2017.01.008
https://doi.org/10.1016/j.ymben.2017.01.008
Autor:
Haimanti Dorai, Subinay Ganguly
Publikováno v:
Current Opinion in Biotechnology. 30:198-204
Therapeutic glycoproteins, for example, antibodies (Abs) and Fc fusion proteins when produced in mammalian cells, such as Chinese hamster ovary (CHO) cells generally exhibit heterogeneity. Both the oligosaccharide moiety and the protein moiety contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441c6557d0c70100826125d0c952f851
https://doi.org/10.1016/j.copbio.2014.07.007
https://doi.org/10.1016/j.copbio.2014.07.007
Autor:
Gordon Powers, John R. Mabus, Amanda L. Kauffman, Jill Giles-Komar, Suzanne E. Thompson, Connie Kliwinski, Philip Cooper, Zhengyin Yan, Haimanti Dorai, Edwin Ragwan, Tam Susan H, Pamela J. Hornby, Benjamin C. Harman
Publikováno v:
Pharmaceutical Research
Purpose To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs). Methods Relative regional expression of F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f95563014050779978fe39a5d022c1a
http://europepmc.org/articles/PMC3953555
http://europepmc.org/articles/PMC3953555
Autor:
Neil, Templeton, Kevin D, Smith, Allison G, McAtee-Pereira, Haimanti, Dorai, Michael J, Betenbaugh, Steven E, Lang, Jamey D, Young
Publikováno v:
Metabolic engineering. 43
Industrial bioprocesses place high demands on the energy metabolism of host cells to meet biosynthetic requirements for maximal protein expression. Identifying metabolic phenotypes that promote high expression is therefore a major goal of the biotech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da8b47033ebbb6d65b154276fb21894c
https://pubmed.ncbi.nlm.nih.gov/28122259
https://pubmed.ncbi.nlm.nih.gov/28122259
Autor:
Susanne Corisdeo, Pam Hawley-Nelson, Subinay Ganguly, Matt Chomo, Dawn Ellis, Michael J. Betenbaugh, Gordon Moore, Cherylann Kinney, Haimanti Dorai
Publikováno v:
Biotechnology and Bioengineering. 109:1016-1030
One of the most important criteria for the successful manufacture of a therapeutic protein (e.g., an antibody) is to develop a mammalian cell line that maintains stability of production. Problems with process yield, lack of effective use of costly re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1638b8b63b4128d3929a7453bdb1a946
https://doi.org/10.1002/bit.24367
https://doi.org/10.1002/bit.24367
Autor:
Marguerite Campbell, Yun Seung Keung, Minhong Zhuang, Dawn Ellis, Chengbin Lin, Michael J. Betenbaugh, Haimanti Dorai
Publikováno v:
Biotechnology Progress. 26:1367-1381
A set of anti-apoptotic genes were over-expressed, either singly or in combination, in an effort to develop robust Chinese Hamster Ovary host cell lines suitable for manufacturing biotherapeutics. High-throughput screening of caspase 3/7 activity ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7fbad7306eb9018ce7d4a57cdde595
https://doi.org/10.1002/btpr.426
https://doi.org/10.1002/btpr.426
Autor:
Yun Seung Kyung, Dawn Ellis, Michael J. Betenbaugh, David Jan, Gordon Moore, Cherylann Kinney, Chengbin Lin, Haimanti Dorai
Publikováno v:
Biotechnology and Bioengineering. 103:592-608
In an effort to develop robust Chinese Hamster Ovary host cell lines, a variety of anti-apoptotic genes were over-expressed, either singly or in combination, followed by screening of transfectants for improved cell growth, extended longevity, reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b015142d0af872bfc91902cbb9a706
https://doi.org/10.1002/bit.22269
https://doi.org/10.1002/bit.22269
Autor:
Subinay Ganguly, Qing Mike Tang, Allen Magill, Jennifer F. Nemeth, Haimanti Dorai, Kristen Picha, Karyn T. O'Neil, T. Shantha Raju, Gordon Moore, Erwin Cammaart, Yonghui Wang, Michael J. Lewis
Publikováno v:
Biotechnology and Bioengineering. 103:162-176
In an attempt to develop a high producing mammalian cell line expressing CNTO736, a Glucagon like peptide-1-antibody fusion protein (also known as a Glucagon like peptide-1 MIMETIBODY), we have noted that the N-terminal GLP-1 portion of the MIMETIBOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ad66a9e920e51ff8de3dc39f424104
https://doi.org/10.1002/bit.22217
https://doi.org/10.1002/bit.22217
Autor:
John R. Mabus, Robert Perkinson, Edwin Ragwan, Gordon Powers, Pamela J. Hornby, Connie Kliwinski, Philip R. Cooper, Jill Giles-Komar, Haimanti Dorai
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Frontiers in Pharmacology
Frontiers in Pharmacology
The neonatal Fc receptor (FcRn) in intestinal epithelium is the primary mechanism for transfer of maternal immunoglobulin G (IgG) from suckled milk to serum; but the factors contributing to the rapid uptake of IgG are poorly understood. These studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08eda08a737c492558bfca8c9ea3ef6
Autor:
Marguerite Campbell, Elaine A. Qian, Haimanti Dorai, Steven E. Lang, Abasha Lewis, Kevin D. Smith, Michael J. Betenbaugh, Jamey D. Young, Neil Templeton
Publikováno v:
Metabolic engineering. 25
Anti-apoptosis engineering is an established technique to prolong the viability of mammalian cell cultures used for industrial production of recombinant proteins. However, the effect of overexpressing anti-apoptotic proteins on central carbon metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcd352aed5583fc2cd084664ea9d250
https://pubmed.ncbi.nlm.nih.gov/25014175
https://pubmed.ncbi.nlm.nih.gov/25014175