Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Haim Y Cohen"'
Autor:
Eitan Okun, Daniel Marton, Daniel Cohen, Kathleen Griffioen, Yariv Kanfi, Tomer Illouz, Ravit Madar, Haim Y Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179681 (2017)
Sirtuins are pleiotropic NAD+ dependent histone deacetylases involved in metabolism, DNA damage repair, inflammation and stress resistance. SIRT6, a member of the sirtuin family, regulates the process of normal aging and increases the lifespan of mal
Externí odkaz:
https://doaj.org/article/3c7b7589c3b94e4a91fe35252162a281
Autor:
Victoria Peshti, Alexey Obolensky, Liat Nahum, Yariv Kanfi, Moran Rathaus, Maytal Avraham, Simon Tinman, Fredrick W Alt, Eyal Banin, Haim Y Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176371 (2017)
The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus, the effect of SIRT6 deficie
Externí odkaz:
https://doaj.org/article/5828971d35ea408f88520d5c4681d65c
Autor:
Moshe Shay Ben-Haim, Yishay Pinto, Sharon Moshitch-Moshkovitz, Vera Hershkovitz, Nitzan Kol, Tammy Diamant-Levi, Michal Schnaider Beeri, Ninette Amariglio, Haim Y. Cohen, Gideon Rechavi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
m6A and m6Am are two prevalent mRNA modifications which are target for removal by the fat mass and obesity gene FTO. Here the authors capture the differential profile of these two modifications in the liver of obese mice and identify dynamic translat
Externí odkaz:
https://doaj.org/article/76e80a062cd54894a7a5299c2888fb86
Autor:
Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular home
Externí odkaz:
https://doaj.org/article/6ccf7a040ef74caca19da73a1a727ed2
Autor:
Asaf A. Gertler, Michal Richman, Menachem Motiei, Hugo E. Gottlieb, Gil Yeroslavsky, Haim Y. Cohen, Shai Rahimipour, Rachela Popovtzer
Publikováno v:
ACS Applied Nano Materials. 4:14126-14135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d753316e682dce892fa0720ad83b4d4
https://doi.org/10.1021/acsanm.1c03487
https://doi.org/10.1021/acsanm.1c03487
Autor:
Uri Amit, David Kain, Allon Wagner, Avinash Sahu, Yael Nevo‐Caspi, Nir Gonen, Natali Molotski, Tal Konfino, Natalie Landa, Nili Naftali‐Shani, Galia Blum, Emmanuelle Merquiol, Danielle Karo‐Atar, Yariv Kanfi, Gidi Paret, Ariel Munitz, Haim Y. Cohen, Eytan Ruppin, Sridhar Hannenhalli, Jonathan Leor
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundThe immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins‐4 and ‐13 are anti‐inflammatory type‐2 cytokines, signaling via the common interleukin‐13 receptor α1 chain and the type‐2 in
Externí odkaz:
https://doaj.org/article/87f0732ac3874443bb7acc9387bf1fb7
Autor:
Sivan Elhanati, Yariv Kanfi, Alexander Varvak, Asael Roichman, Ilana Carmel-Gross, Shaul Barth, Gilad Gibor, Haim Y. Cohen
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 905-912 (2013)
The NAD+-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and lifespan. Mice overexpressing SIRT6 (MOSES) have lower low-density lipoprotein cholesterol levels and are protected against the physiological damage of obesity. Here
Externí odkaz:
https://doaj.org/article/40ec652d95a4433f8056d09c69c5ae2b
Autor:
Orr Levy, Yang-Yu Liu, Peter J. Castaldi, Haim Y. Cohen, Amir Bashan, Guy Amit, Sol Efroni, Dana Vaknin, Tom Snir
Publikováno v:
Nature Metabolism. 2:1305-1315
A long-standing model holds that stochastic aberrations of transcriptional regulation play a key role in the process of ageing. While transcriptional dysregulation is observed in many cell types in the form of increased cell-to-cell variability, its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f15c2f2de12d0e7270818176c38ed05
https://doi.org/10.1038/s42255-020-00304-4
https://doi.org/10.1038/s42255-020-00304-4
Autor:
Ifat Abramovich, Doron Gerber, Matthew D. Hirschey, Olga Ilkayeva, Yael Shahar, Asaf A. Gertler, Asael Roichman, Yair Glick, Noga Touitou, Haim Y. Cohen, Orly Yaron, Matan Y. Avivi, Liat Nahum, Robert A. Harris, Frank K. Huynh, Reuven Gil, Yariv Kanfi, Eyal Gottlieb, Shoshana Naiman, Batia Lerrer, Tirza Doniger
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4127-4143.e8 (2019)
Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0fdd89fedfd6c7785ea89d63a1ca0
http://www.sciencedirect.com/science/article/pii/S221112471931558X
http://www.sciencedirect.com/science/article/pii/S221112471931558X
Autor:
Haim Y. Cohen, A. Di Francesco, Orly Yaron, Alexey E. Lyashkov, Yael Shahar, I. Lebenthal-Loinger, Batya Lerrer, Asael Roichman, Miguel A. Aon, Matan Y. Avivi, Sivan Elhanati, Pablo J. Fernandez-Marcos, Yariv Kanfi, Ceereena Ubaida-Mohien, A. Shuchami, Ifat Abramovich, Manuel Serrano, Z. Petrover, R. de Cabo, Eyal Gottlieb, M. Shurgi, Y. Wiesner, A. Rubinstein
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms that largely remain unknown. Here, we show that SIRT6 overexpression leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6def2446946f4ce3fd3c05338acece95
https://doi.org/10.1038/s41467-021-23545-7
https://doi.org/10.1038/s41467-021-23545-7