Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Haim Ovadia"'
Intracranial Assessment of Androgen Receptor Antagonists in Mice Bearing Human Glioblastoma Implants
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 332 (2023)
The median survival time of patients with an aggressive brain tumor, glioblastoma, is still poor due to ineffective treatment. The discovery of androgen receptor (AR) expression in 56% of cases offers a potential breakthrough. AR antagonists, includi
Externí odkaz:
https://doaj.org/article/8eb844b5766e4c4caa8cf2e3de043e64
Autor:
Chaim Gilon, Michal Klazas, Adi Lahiani, Adi Schumacher-Klinger, Shira Merzbach, Johnny N. Naoum, Haim Ovadia, Limor Rubin, Susan Cornell-Kennon, Erik M. Schaefer, Jehoshua Katzhendler, Cezary Marcinkiewicz, Amnon Hoffman, Philip Lazarovici
Publikováno v:
JACS Au, Vol 1, Iss 12, Pp 2361-2376 (2021)
Externí odkaz:
https://doaj.org/article/d3a290a521dd414dba56442f22ad6166
Publikováno v:
Vision, Vol 5, Iss 2, p 29 (2021)
Nitric oxide (NO) is acknowledged as a vital intercellular messenger in multiple systems in the body. Medicine has focused on its functions and therapeutic applications for decades, especially in cardiovascular and nervous systems, and its role in im
Externí odkaz:
https://doaj.org/article/cf7623f8a12c47c2987523c3886d2a22
Autor:
Keren Turjeman, Yaelle Bavli, Pablo Kizelsztein, Yaelle Schilt, Nahum Allon, Tamar Blumenfeld Katzir, Efrat Sasson, Uri Raviv, Haim Ovadia, Yechezkel Barenholz
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130442 (2015)
The present study shows the advantages of liposome-based nano-drugs as a novel strategy of delivering active pharmaceutical ingredients for treatment of neurodegenerative diseases that involve neuroinflammation. We used the most common animal model f
Externí odkaz:
https://doaj.org/article/f5e90184f4de4ffb9c74297707768ce1
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 2, Pp 282-285 (2005)
Results from several laboratories indicate that apoptosis via the P53 pathway is involved in prion disease pathogenesis. Prion diseases, among them scrapie and BSE, are a group of fatal neurodegenerative disorders associated with the conversion of Pr
Externí odkaz:
https://doaj.org/article/58742badb69d40b68ce5053c66f5b7e4
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113854 (2014)
Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival. Therefore, it is conceivable to consider MGMT as a potential thera
Externí odkaz:
https://doaj.org/article/139ed05d78dd4c6c8582d0ce57669df4
Autor:
Judith H Waknine-Grinberg, Simcha Even-Chen, Jasmine Avichzer, Keren Turjeman, Annael Bentura-Marciano, Richard K Haynes, Lola Weiss, Nahum Allon, Haim Ovadia, Jacob Golenser, Yechezkel Barenholz
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72722 (2013)
Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in malaria-endemic areas. We report high therapeutic efficacy of a novel formulation of liposome-encap
Externí odkaz:
https://doaj.org/article/e38470b5a7494f86b8547a0492e26c36
Publikováno v:
Vision, Vol 5, Iss 29, p 29 (2021)
Vision
Vision
Nitric oxide (NO) is acknowledged as a vital intercellular messenger in multiple systems in the body. Medicine has focused on its functions and therapeutic applications for decades, especially in cardiovascular and nervous systems, and its role in im
Autor:
Bracha Zelikovitch, Hanna Charbit, Stav Rabani, Tamar Canello, Anat Mordechai, Haim Ovadia, Yakov Fellig, Tal Shahar, Iris Lavon, Alexander Lossos, Nomi Zalcman
Publikováno v:
Oncotarget
The median survival time of patients with glioblastoma is still poor (14.6 month), partly due to a lack of effective treatment. We have observed that androgen receptor (AR) is amplified in glioblastomas at the DNA, RNA and protein levels. The AR gene
Autor:
Eli Okon, Mary K. Cowman, Shulamit B. Wallach-Dayan, Jorge Alemany, David Naor, Darja Kanduc, Xiayun Huang, Lora Eshkar-Sebban, Keren Or Amar, Libat Bar Lev, Maayan Hemed-Shaked, Sharona Elgavish, Jordi Armengol, Michal Melamed, Shaul Beyth, Jin Ryoun Kim, Haim Ovadia, Eli Kedar, Shmuel Cohen, Edward Chau
Publikováno v:
Journal of Autoimmunity. 124:102713
Despite the existence of potent anti-inflammatory biological drugs e.g., anti-TNF and anti IL-6 receptor antibodies, for treating chronic inflammatory and autoimmune diseases, these are costly and not specific. Cheaper oral available drugs remain an