Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Haim Barr"'
Autor:
Danielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander Plotnikov, Haim Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth, Efrat Shema
Publikováno v:
eLife, Vol 13 (2024)
Diffuse midline gliomas (DMGs) are aggressive and fatal pediatric tumors of the central nervous system that are highly resistant to treatments. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, resh
Externí odkaz:
https://doaj.org/article/d63328b5980f4190895f7d76cb98e2cf
Autor:
Minhua Su, Tom Fleisher, Inna Grosheva, Melanie Bokstad Horev, Malgorzata Olszewska, Camilla Ciolli Mattioli, Haim Barr, Alexander Plotnikov, Silvia Carvalho, Yoni Moskovich, Mark D. Minden, Noa Chapal-Ilani, Alexander Wainstein, Eirini P. Papapetrou, Nili Dezorella, Tao Cheng, Nathali Kaushansky, Benjamin Geiger, Liran I. Shlush
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109443- (2024)
Summary: Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking. In the current study, we used an in vitro high-throughput drug screen among four differ
Externí odkaz:
https://doaj.org/article/0f0b14d6b7ce4b4cbbdae7d1354a29e0
Autor:
Nathaniel L. Gould, Gila R. Scherer, Silvia Carvalho, Khriesto Shurrush, Haneen Kayyal, Efrat Edry, Alina Elkobi, Orit David, Maria Foqara, Darshit Thakar, Tommaso Pavesi, Vijendra Sharma, Matthew Walker, Matthew Maitland, Orly Dym, Shira Albeck, Yoav Peleg, Nicolas Germain, Ilana Babaev, Haleli Sharir, Maya Lalzar, Boris Shklyar, Neta Hazut, Mohammad Khamaisy, Maxime Lévesque, Gilles Lajoie, Massimo Avoli, Gabriel Amitai, Bruce Lefker, Chakrapani Subramanyam, Brian Shilton, Haim Barr, Kobi Rosenblum
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer’s disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, i
Externí odkaz:
https://doaj.org/article/ac5cf5dd51f14d3ba8d30c4735cde0de
Autor:
Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar, Rellie Gez, Dan Loewenthal, Khriesto A. Shurrush, Galit Cohen, Leonardo J. Solmesky, Haim Barr, Alan J. Russell
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxifi
Externí odkaz:
https://doaj.org/article/ac7bf1ed74314e84bce92d5d5c901cca
Autor:
Sigal Tavor, Tali Shalit, Noa Chapal Ilani, Yoni Moskovitz, Nir Livnat, Yoram Groner, Haim Barr, Mark D. Minden, Alexander Plotnikov, Michael W. Deininger, Nathali Kaushansky, Liran I. Shlush
Publikováno v:
Haematologica, Vol 105, Iss 12 (2020)
Novel targeted therapies demonstrate improved survival in specific subgroups (defined by genetic variants) of acute myeloid leukemia (AML) patients, validating the paradigm of molecularly targeted therapy. However, identifying correlations between AM
Externí odkaz:
https://doaj.org/article/bbb351a6ca2341a399bd41c89409281d
Autor:
Gal Chaim Nuta, Yuval Gilad, Nadav Goldberg, Sara Meril, Marcela Bahlsen, Silvia Carvalho, Noga Kozer, Haim Barr, Yael Fridmann Sirkis, Kamil Hercík, Petra Břehová, Radim Nencka, Shani Bialik, Miriam Eisenstein, Adi Kimchi
Publikováno v:
Autophagy. :1-14
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
Autor:
Rambabu N. Reddi, Adi Rogel, Ronen Gabizon, Dattatraya Gautam Rawale, Battu Harish, Shir Marom, Barr Tivon, Yamit Shorer Arbel, Neta Gurwicz, Roni Oren, Keren David, Jingjing Liu, Shirly Duberstein, Maxim Itkin, Sergey Malitsky, Haim Barr, Ben-Zion Katz, Yair Herishanu, Idit Shachar, Ziv Shulman, Nir London
Publikováno v:
Journal of the American Chemical Society. 145:3346-3360
Autor:
Paul Gehrtz, Shir Marom, Mike Bührmann, Julia Hardick, Silke Kleinbölting, Amit Shraga, Christian Dubiella, Ronen Gabizon, Jan N. Wiese, Matthias P. Müller, Galit Cohen, Ilana Babaev, Khriesto Shurrush, Liat Avram, Efrat Resnick, Haim Barr, Daniel Rauh, Nir London
Publikováno v:
Journal of Medicinal Chemistry. 65:10341-10356
Autor:
William McCorkindale, Ivan Ahel, Haim Barr, Galen J. Correy, James S. Fraser, Nir London, Marion Schuller, Khriesto Shurrush, Alpha A. Lee
The process of finding molecules that bind to a target protein is a challenging first step in drug discovery. Crystallographic fragment screening is a strategy based on elucidating binding modes of small polar compounds and then building potency by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ecc3e36ddd45cb02ed3024598697ac6
https://doi.org/10.1101/2022.11.21.517375
https://doi.org/10.1101/2022.11.21.517375
Autor:
Ronen Gabizon, Rambabu N. Reddi, Nir London, Adi Rogel, Ziv Shulman, Neta Gurwicz, Efrat Resnick, Daniel Zaidman, Kim Goldenberg, Alexander Plotnikov, Haim Barr, Boddu Venkateswara Rao
Publikováno v:
Journal of the American Chemical Society
Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of elec