Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Haim, Werner"'
Autor:
Lina Somri-Gannam, Shilhav Meisel-Sharon, Shay Hantisteanu, Tomer Bar-Noy, Emiliya Sigal, Gabriel Groisman, Mordechai Hallak, Haim Werner, Ilan Bruchim
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionThe insulin-like growth factor (IGF) system plays a key role in regulating growth and invasiveness in epithelial ovarian cancer (EOC) and is considered a promising therapeutic target. EOC is an immunosuppressive disease, although there ar
Externí odkaz:
https://doaj.org/article/64fd6a5e15684482801a516d4d590d82
Autor:
Haim Werner, Zvi Laron
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The growth hormone (GH)-insulin-like growth factor-1 (IGF1) signaling pathway emerged in recent years as a key determinant of aging and longevity. Disruption of this network in different animal species, including flies, nematodes and mouse, was consi
Externí odkaz:
https://doaj.org/article/87ae8de496ce4aa290e5650019afed85
Autor:
Haim Werner, Leonard Girnita
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b44ae36bdf784015993d8d28b0b61458
Autor:
Haim Werner, Derek LeRoith
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The identification of a series of attributes or hallmarks that are shared by virtually all cancer cells constitutes a true milestone in cancer research. The conceptualization of a catalogue of common genetic, molecular, biochemical and cellular event
Externí odkaz:
https://doaj.org/article/79da0c877e514577bed0a3f6a9871644
Autor:
Haim Werner
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The breast and ovarian cancer susceptibility gene (BRCA1) is a tumor suppressor whose mutation has been associated with the development of breast, ovarian and, probably, other malignancies at young ages. The BRCA1 gene product participates in multipl
Externí odkaz:
https://doaj.org/article/dff637902918428c9d182b4bbc8370f4
Publikováno v:
Cells, Vol 11, Iss 20, p 3260 (2022)
The growth hormone (GH)–insulin-like growth factor-1 (IGF1) signaling pathway plays a major role in orchestrating cellular interactions, metabolism, growth and aging. Studies from worms to mice showed that downregulated activity of the GH/IGF1 path
Externí odkaz:
https://doaj.org/article/26c96e13378b490baa8aab386580619a
Autor:
Laris Achlaug, Lina Somri-Gannam, Shilhav Meisel-Sharon, Rive Sarfstein, Manisha Dixit, Shoshana Yakar, Mordechai Hallak, Zvi Laron, Haim Werner, Ilan Bruchim
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
The insulin-like growth factors (IGF) are important players in the development of gynecological malignancies, including epithelial ovarian cancer (EOC). The identification of biomarkers that can help in the diagnosis and scoring of EOC patients is of
Externí odkaz:
https://doaj.org/article/1afbe2b029f3461694ba8b14108ce8cf
Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action
Autor:
Rive Sarfstein, Karthik Nagaraj, Shivang Parikh, Carmit Levy, Zvi Laron, Dafna Benayahu, Haim Werner
Publikováno v:
Cells, Vol 11, Iss 10, p 1627 (2022)
Normal growth and development in mammals are tightly controlled by numerous genetic factors and metabolic conditions. The growth hormone (GH)-insulin-like growth factor-1 (IGF1) hormonal axis is a key player in the regulation of these processes. Dysr
Externí odkaz:
https://doaj.org/article/849f6f5318a646e0bf37f3ee2029a558
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Insulin and insulin-like growth factor-1 (IGF1), acting respectively via the insulin (INSR) and IGF1 (IGF1R) receptors, play key developmental and metabolic roles throughout life. In addition, both signaling pathways fulfill important roles in cancer
Externí odkaz:
https://doaj.org/article/2649fdf8246445f0b41a26908d4eff1c
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract The insulin-like growth factor-1 receptor (IGF1R) has been identified as a potent anti-apoptotic, pro-survival tyrosine kinase-containing receptor. Overexpression of the IGF1R gene constitutes a typical feature of most human cancers. Consist
Externí odkaz:
https://doaj.org/article/4ee528b3e1b445cab57f8db1b406dd52