Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Haim, Rozenberg"'
Autor:
Oksana Degtjarik, Dmitrij Golovenko, Yael Diskin-Posner, Lars Abrahmsén, Haim Rozenberg, Zippora Shakked
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The tumor suppressor p53 is mutated in more than half of human cancers and the compound methylene quinuclidinone (MQ) was shown to reactivate p53 mutants by binding covalently to cysteine residues. Here, the authors present crystal structures of wild
Externí odkaz:
https://doaj.org/article/61ab66026ad342f6901e1b078e2ffc95
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize lo
Externí odkaz:
https://doaj.org/article/d98248e72e7a43afad2cce3d9fb3924e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
Externí odkaz:
https://doaj.org/article/d5126a2928d24e2daeb886140544fdec
Autor:
Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highligh
Externí odkaz:
https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d88
Autor:
Moran Shalev-Benami, Yan Zhang, Donna Matzov, Yehuda Halfon, Arie Zackay, Haim Rozenberg, Ella Zimmerman, Anat Bashan, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 288-294 (2016)
Leishmania is a single-cell eukaryotic parasite of the Trypanosomatidae family, whose members cause an array of tropical diseases. The often fatal outcome of infections, lack of effective vaccines, limited selection of therapeutic drugs, and emerging
Externí odkaz:
https://doaj.org/article/6b7985b7448545f39a7420e4af650987
Autor:
Giuseppe Cimicata, Analia V. Ezernitchi, Moti Baum, Y. Halfon, Elinor Breiner-Goldstein, Anat Bashan, Ella Zimmerman, Jennifer J. Schmidt, Donna Matzov, Lea Valinsky, Assaf Rokney, Haim Rozenberg, Andrew N. Lowell, Yojiro Anzai, Z. Eyal, David H. Sherman, Ada Yonath
Publikováno v:
'Nucleic Acids Research ', vol: 49, pages: 9560-9573 (2021)
Nucleic Acids Research
Nucleic Acids Research
Macrolides have been effective clinical antibiotics for over 70 years. They inhibit protein biosynthesis in bacterial pathogens by narrowing the nascent protein exit tunnel in the ribosome. The macrolide class of natural products consist of a macrola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
Nature Communications
Nature Communications
Autor:
Tamar Auerbach-Nevo, David Baram, Anat Bashan, Matthew Belousoff, Elinor Breiner, Chen Davidovich, Giuseppe Cimicata, Zohar Eyal, Yehuda Halfon, Miri Krupkin, Donna Matzov, Markus Metz, Mruwat Rufayda, Moshe Peretz, Ophir Pick, Erez Pyetan, Haim Rozenberg, Moran Shalev-Benami, Itai Wekselman, Raz Zarivach, Ella Zimmerman, Nofar Assis, Joel Bloch, Hadar Israeli, Rinat Kalaora, Lisha Lim, Ofir Sade-Falk, Tal Shapira, Leena Taha-Salaime, Hua Tang, Ada Yonath
Publikováno v:
Antibiotics, Vol 5, Iss 3, p 24 (2016)
Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation. Owing to the global rapid increase in the appearance
Externí odkaz:
https://doaj.org/article/38f282b678d544b195b47abf37f54af3
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Allostery is a pervasive principle to regulate protein function. Growing evidence suggests that also DNA is capable of transmitting allosteric signals. Yet, whether and how DNA-mediated allostery plays a regulatory role in gene expression remained un
SummaryAllostery is a pervasive principle to regulate protein function. Here, we show that DNA also transmits allosteric signals over long distances to boost the binding cooperativity of transcription factors. Phenotype switching inBacillus subtilisr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bbde1232aac565c4d56d28abde4f184
https://doi.org/10.1101/2020.07.04.187450
https://doi.org/10.1101/2020.07.04.187450