Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Hailian Xiao"'
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Sruti Rayaprolu, Sara Bitarafan, Juliet V. Santiago, Ranjita Betarbet, Sydney Sunna, Lihong Cheng, Hailian Xiao, Ruth S. Nelson, Prateek Kumar, Pritha Bagchi, Duc M. Duong, Annie M. Goettemoeller, Viktor János Oláh, Matt Rowan, Allan I. Levey, Levi B. Wood, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Current isolation-based approaches for cell type-specific proteomics pose several challenges. Here, the authors present an approach for in vivo cell type-specific protein labeling to characterize proteomic differences between neurons and astrocytes i
Externí odkaz:
https://doaj.org/article/0366b13af39b4d438b5baee2a2a9c33d
Autor:
Sruti Rayaprolu, Tianwen Gao, Hailian Xiao, Supriya Ramesha, Laura D. Weinstock, Jheel Shah, Duc M. Duong, Eric B. Dammer, James A. Webster, James J. Lah, Levi B. Wood, Ranjita Betarbet, Allan I. Levey, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-22 (2020)
Abstract Background Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by low cellular yield and
Externí odkaz:
https://doaj.org/article/d7c72d1d44654f4abfd3eb413217f735
Autor:
Anthony W.S. Chan, In Ki Cho, Chun-Xia Li, Xiaodong Zhang, Sudeep Patel, Rebecca Rusnak, Jessica Raper, Jocelyne Bachevalier, Sean P. Moran, Tim Chi, Katherine H. Cannon, Carissa E. Hunter, Ryan C. Martin, Hailian Xiao, Shang-Hsun Yang, Sanjeev Gumber, James G. Herndon, Rebecca F. Rosen, William T. Hu, James J. Lah, Allan I. Levey, Yoland Smith, Lary C. Walker
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100044- (2022)
With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene into rhesus
Externí odkaz:
https://doaj.org/article/e37b891206f5479e91e23e9f894ea295
Autor:
Tianwen Gao, Syed Ali Raza, Supriya Ramesha, Ngozi V. Nwabueze, Amelia J. Tomkins, Lihong Cheng, Hailian Xiao, Manuel Yepes, Srikant Rangaraju
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke. Selective inhibition of pro-inflammatory responses can be achieved by Kv
Externí odkaz:
https://doaj.org/article/1e7c74655e0240a7b3d0ea507bb54c77
Publikováno v:
IEEE Access, Vol 7, Pp 17760-17771 (2019)
The resource-oriented Petri net (ROPN) modeling method is applied in this paper to model a class of automated manufacturing systems (AMS) named disjunctive and strict single-type AMSs (DS-AMS), where multiple units of a single resource type are requi
Externí odkaz:
https://doaj.org/article/2f6326393da049fda30796343010d6c7
Autor:
Souvarish Sarkar, Eric B. Dammer, Emir Malovic, Abby L. Olsen, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Danielle L. Oliver, Duc Duong, Valerie Joers, Nicholas Seyfried, Meixiang Huang, Thomas Kukar, Malú G. Tansey, Anumantha G. Kanthasamy, Srikant Rangaraju
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and immune-mediated neurotoxicity, but the molecular mechanisms of αSynAgg-induced immune activation are
Externí odkaz:
https://doaj.org/article/88a10c77d6fa4f4a901fe44bb0db0cdd
Autor:
Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Ranjita Betarbet, Duc M. Duong, James A. Webster, Chadwick M. Hales, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2018)
Abstract Background Microglia are innate immune cells of the brain that perform phagocytic and inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated microglia have provided novel insights into their molecular and fu
Externí odkaz:
https://doaj.org/article/97f332832b444815b171526194a5220f
Autor:
Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Priyadharshini Rathakrishnan, Hailian Xiao, Tianwen Gao, Duc M. Duong, Michael W. Pennington, James J. Lah, Nicholas T. Seyfried, Allan I. Levey
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-25 (2018)
Abstract Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer’s disease (AD). An understanding of heterogeneity within DAM and t
Externí odkaz:
https://doaj.org/article/9b23d42179b04772af58b32c842c4a9a
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005073 (2015)
Biological diversity on Earth depends on the multiplication of species or speciation, which is the evolution of reproductive isolation such as hybrid sterility between two new species. An unsolved puzzle is the exact mechanism(s) that causes two geno
Externí odkaz:
https://doaj.org/article/6413e7ea2279403197f5b19f6d095ad9