Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hailey Wyatt"'
Autor:
Sarah B Goldberg, Kurt A Schalper, Harriet M Kluger, Lucia B Jilaveanu, Adebowale J Adeniran, Benjamin Y Lu, Adam Aguirre-Ducler, Nicole Gianino, Hailey Wyatt, Matthew Ribeiro, Veronica L Chiang, Joseph N Contessa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/c944367d1c9b437186ea68e2217f1c32
Autor:
Adil Rasheed, Taylor Dennison, Hailey Wyatt, My-anh Nguyen, Sabrina Robichaud, Michele Geoffrion, Adir Baxi, Richard Lee, Mireille I Ouimet, Katey J Rayner
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
The mixed lineage kinase domain-like protein (MLKL) was first discovered in 2012 as the executioner of necroptosis. In line with this, we showed that MLKL knockdown ( Mlkl KD) by administration of antisense oligonucleotides to atherosclerotic-prone A
Autor:
My-Anh Nguyen, Huy-Dung Hoang, Adil Rasheed, Anne-Claire Duchez, Hailey Wyatt, Mary Lynn Cottee, Tyson E. Graber, Leah Susser, Sabrina Robichaud, İbrahim Berber, Michele Geoffrion, Mireille Ouimet, Hilal Kazan, Lars Maegdefessel, Erin E. Mulvihill, Tommy Alain, Katey J. Rayner
Background: A significant burden of atherosclerotic disease is driven by inflammation. Recently, microRNAs (miRNAs) have emerged as important factors driving and protecting from atherosclerosis. miR-223 regulates cholesterol metabolism and inflammati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7dbec55f9278451a5e607006be6e9a
http://hdl.handle.net/20.500.12566/1440
http://hdl.handle.net/20.500.12566/1440
Autor:
Liang Guo, Zachary Lister, Renu Virmani, Katey J. Rayner, Francis J. Alenghat, Ana Mompeon, Calvin Pan, Dianne Vreeken, Hailey Wyatt, Emma Gordon, Adil Rasheed, Nicola Otte, Joshua W. Kandiah, Ulf Hedin, Patricia Essebier, Denuja Karunakaran, My-Anh Nguyen, Frank D. Kolodgie, Ljubica Perisic Matic, Jason E. Fish, Richard G. Lee, Peter Liu, Henry S. Cheng, Aldons J. Lusis, Richard G. Jung, Michele Geoffrion, Janine M. van Gils
Publikováno v:
Circulation, 143(2), 163-177. Lippincott, Williams & Wilkins
Background: Chronic activation of the innate immune system drives inflammation and contributes directly to atherosclerosis. We previously showed that macrophages in the atherogenic plaque undergo RIPK3 (receptor-interacting serine/threonine-protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::face3ebf856d243a810ed095bf400cd2
http://hdl.handle.net/1887/3195267
http://hdl.handle.net/1887/3195267
Autor:
Richa Gupta, Joseph N. Contessa, Adebowale J. Adeniran, Hailey Wyatt, Kurt A. Schalper, Benjamin Y. Lu, Nicole Gianino, Adam Aguirre-Ducler, Sarah B. Goldberg, Lucia B. Jilaveanu, Veronica Chiang, Matthew Ribeiro, Harriet M. Kluger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Despite unique genetic alterations within brain metastases (BrMs) and an immunologically distinct surrounding microenvironment, the composition and functional properties of tumor-infiltrating lymphocytes within BrM remain largely unexplored. In parti
Autor:
Adil Rasheed, Hailey Wyatt, Taylor Dennison, My-anh Nguyen, Sabrina Robichaud, Michele Geoffrion, Adir Baxi, Richard Lee, Mireille I Ouimet, Katey J Rayner
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
During atherosclerosis, macrophages within the aorta undergo necroptosis, a mode of pro-inflammatory cell death that is triggered by the phosphorylation of RIPK1 & RIPK3 and leads to the activation of the mixed lineage kinase domain-like protein (MLK
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells
Autor:
Yu Shyr, Yong Kong, Shuangge Ma, Hailey Wyatt, Kaylyn Clairmont, Victoria Quintana, Shilin Zhao, Kurt A. Schalper, Zachary D. Nagel, Rithy Meas, Patricia LoRusso, Sebastian Oeck, Isabel Alvarado-Cruz, Angelo Porciuncula, Ying Zhu, Daniel J. Laverty, Michael Krauthammer, Mariam M. Mahmoud, Joann B. Sweasy, Mohammed Khan
Publikováno v:
Biochem Pharmacol
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors (PARPi) have been suggested to act by either catalytic inhibition or by PARP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be385c651532db58837877fc5a7fae6
https://www.ncbi.nlm.nih.gov/pubmed/33285109
https://www.ncbi.nlm.nih.gov/pubmed/33285109
Autor:
Richa Gupta, Matthew Ribeiro, Elin Rowen, Scott N. Gettinger, Geyu Zhou, Yuval Kluger, Kira F. Pavlik, Sarah B. Goldberg, Thuy Tran, Harriet M. Kluger, Wei Wei, Lucia B. Jilaveanu, Amit Mahajan, Annette Komlo, Frederick H. Wilson, Heather Gerrish, Hailey Wyatt, James B. Yu, Veronica Chiang, Roy S. Herbst, Rogerio Lilenbaum, Anne C. Chiang, Sacit Bulent Omay, Kurt A. Schalper
Publikováno v:
Lancet Oncol
Summary Background We did a phase 2 trial of pembrolizumab in patients with non-small-cell lung cancer (NSCLC) or melanoma with untreated brain metastases to determine the activity of PD-1 blockade in the CNS. Interim results were previously publishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1088e36781675f5dda7cda656054334d
https://europepmc.org/articles/PMC7380514/
https://europepmc.org/articles/PMC7380514/
Autor:
Mary Lynn Cottee, Taylor Dennison, Richard G. Lee, Thomas A. Lagace, Antonietta Pietrangelo, Hailey Wyatt, Sabrina Robichaud, My-Anh Nguyen, Adil Rasheed, Michele Geoffrion, Mireille Ouimet, Katey J. Rayner
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 40(5)
Objectives: During the advancement of atherosclerosis, plaque cellularity is governed by the influx of monocyte-derived macrophages and their turnover via apoptotic and nonapoptotic forms of cell death. Previous reports have demonstrated that program
Autor:
Rithy Meas, Daniel J. Laverty, Kaylyn Clairmont, Victoria Quintana, Isabel Alvarado-Cruz, Patricia LoRusso, Sebastian Oeck, Hailey Wyatt, Kurt A. Schalper, Mariam M. Mahmoud, Angelo Porciuncula, Ying Zhu, Joann B. Sweasy, Mohammed Khan, Yu Shyr, Yong Kong, Zachary D. Nagel, Shuangge Ma, Shilin Zhao, Michael Krauthammer
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors have been suggested to act by either catalytic inhibition or by PARP localiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b249682be3db497cd9f36a1bfda2780
https://doi.org/10.1101/2020.03.08.982785
https://doi.org/10.1101/2020.03.08.982785