Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hailey R. Lee"'
Autor:
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is inc
Externí odkaz:
https://doaj.org/article/e438254920ee4e73ba0fa35c8e36bf84
Autor:
Thuc M. Le, Hailey R. Lee, Evan R. Abt, Khalid Rashid, Amanda L. Creech, Keke Liang, Jing Cui, Arthur Cho, Liu Wei, Amanda Labora, Charlotte Chan, Eric Sanchez, Kriti Kriti, Daniel Karin, Luyi Li, Nanping Wu, Christine Mona, Giuseppe Carlucci, Willy Hugo, Ting-Ting Wu, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 64, iss 1
J Nucl Med
J Nucl Med
Stimulator of interferon genes (STING) is a mediator of immune recognition of cytosolic DNA, which plays important roles in cancer, cytotoxic therapies, and infections with certain pathogens. Although pharmacologic STING activation stimulates potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfa01717ada663eac3090e4fe01b4a7
https://escholarship.org/uc/item/9w54v9cm
https://escholarship.org/uc/item/9w54v9cm
Autor:
Kathleen M. Yee, Richard W. Shuai, Bin Liu, Christian A. Huynh, Chao Niu, Hailey R. Lee, Min S. Lee, Jirui Wen, Jian Zou, Jiang Wu, Ke Shuai
Neutrophils are rapidly recruited from the peripheral blood to the inflammatory site to initiate inflammatory response against pathogenic infections. The process to recruit neutrophils must be properly regulated since the abnormal accumulation of neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e12ba3b1dc65cdea906ddc52ff7d85
https://doi.org/10.1101/2021.09.07.459280
https://doi.org/10.1101/2021.09.07.459280
Autor:
Evan R. Abt, Khalid Rashid, Thuc M. Le, Hailey R. Lee, Amanda L. Creech, Ting-Ting Wu, Thomas Mehrling, Shanta Bantia, Caius G. Radu
Publikováno v:
Cancer Research. 82:3034-3034
Purine nucleoside phosphorylase (PNP) functions as a central regulator of nucleotide metabolism by catalyzing the degradation of purine nucleosides guanosine and deoxyguanosine. PNP inactivation has been paradoxically associated with both immunodefic
Autor:
Hailey R. Lee, Evan R. Abt, Khalid Rashid, Amanda L. Creech, Keke Liang, Liu Wei, Arthur Cho, Willy Hugo, Timothy R. Donahue, Johannes Czernin, Caius G. Radu, Thuc M. Le
Publikováno v:
Cancer Research. 82:2483-2483
Stimulator of interferon genes (STING) coordinates innate and adaptive immune responses by mediating type I interferon and NF-κB signaling and is therefore a promising cancer immunotherapy target. While first generation STING agonists have advanced
Autor:
Jie Deng, Scott C. Chin, Mito Tariveranmoshabad, Danielle S. Graham, Hailey R. Lee, Marisol Quintero, Dorthe Schaue, Anusha Kalbasi
Publikováno v:
Cancer Research. 82:3446-3446
Background: Undifferentiated pleomorphic sarcoma (UPS) is a common aggressive sarcoma subtype for which existing therapies are ineffective. Immune checkpoint blockade (ICB) is effective in a minority of patients whose tumors harbor a pre-existing lym
Autor:
Timothy R. Donahue, Caius G. Radu, Thuc Le, Nanping Wu, Evan R. Abt, Khalid Rashid, Vincent Lok, Robert Damoiseaux, David W. Dawson, Woosuk Kim, Joseph R. Capri, Amanda M. Dann, Soumya Poddar, Luyi Li, Ethan W. Rosser, Ting-Ting Wu, Keke Liang, Johannes Czernin, Hailey R. Lee, Jing Cui, Amanda L. Creech
Publikováno v:
SSRN Electronic Journal.
An inflammatory, cytokine-rich tumor microenvironment is a defining feature of pancreatic ductal adenocarcinoma (PDAC). Among proinflammatory cytokines, type I interferons (IFNs) are particularly important as they regulate the expression of hundreds