Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hailey Olafson"'
Autor:
Chialin Cheng, Surya A. Reis, Emily T. Adams, Daniel M. Fass, Steven P. Angus, Timothy J. Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T. Wang, Debasis Patnaik, Roberta L. Beauchamp, Danielle A. Feldman, M. Catarina Silva, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Bruce L. Miller, Sally Temple, Kenneth S. Kosik, Bradford C. Dickerson, Stephen J. Haggarty
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons u
Externí odkaz:
https://doaj.org/article/dbd7b9c359124c2ab41cec4cd38e2e30
Autor:
Hailey Olafson, Amrutha Pattamatta, Jared I Richardson, J. Andrew Berglund, Tao Zu, Marina M. Scotti, Lauren A. Laboissonniere, Laura P.W. Ranum, Lien Nguyen, Eric T. Wang
Publikováno v:
Hum Mol Genet
C9orf72 ALS/FTD patients show remarkable clinical heterogeneity, but the complex biology of the repeat expansion mutation has limited our understanding of the disease. BAC transgenic mice were used to better understand the molecular mechanisms and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e3e6be06d716eb32b912ed1db42ecd
https://doi.org/10.1093/hmg/ddaa279
https://doi.org/10.1093/hmg/ddaa279
Autor:
Jeffrey D. Rothstein, Jonathan L. Chen, Montina Van Meter, Tania F. Gendron, Alyssa N. Coyne, Yong Jie Zhang, Eric T. Wang, Yue Li, Ilyas Yildirim, Rita Fuerst, Jessica A. Bush, Leonard Petrucelli, Samantha M. Meyer, Hailey Olafson, Jessica L. Childs-Disney, Kye Won Wang, Yuquan Tong, Kendra K. McKee, Raphael I. Benhamou, Tanya Khan, Andrei Ursu, Matthew D. Disney, Sarah Wagner-Griffin, Haruo Aikawa
Publikováno v:
Sci Transl Med
The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD) is an expanded G(4)C(2) RNA repeat [r(G(4)C(2))(exp)] in chromosome 9 open reading frame 72 (C9orf72), which elicits pathology through several mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7323437f11575a5a155e154c7f4b4
https://europepmc.org/articles/PMC9533739/
https://europepmc.org/articles/PMC9533739/
Autor:
Daniel M. Fass, Roberta L. Beauchamp, Steven P. Angus, Chialin Cheng, Kenneth S. Kosik, Timothy J. Stuhlmiller, Bradford C. Dickerson, Bruce L. Miller, Debasis Patnaik, Danielle A. Feldman, Jared I Richardson, Stephen J. Haggarty, Hailey Olafson, Surya A. Reis, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Eric T. Wang, Sally Temple, Emily T Adams, M. Catarina Silva
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons ultimately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648e69bd4afba94c17b3f3502a46e0b7
http://europepmc.org/articles/PMC8382845
http://europepmc.org/articles/PMC8382845
Autor:
John W. Day, Sam Sedehizadeh, Thomas A. Cooper, Charles A. Thornton, Christopher B. Burge, Daniel J. Treacy, Thomas T. Wang, David E. Housman, Katy Eichinger, Amanda J. Ward, J. Andrew Berglund, Adam J. Struck, Kirti Bhatt, Joseph Estabrook, Eric T. Wang, David Brook, Hailey Olafson, Tony Westbrook
Publikováno v:
Human Molecular Genetics. 28:1312-1321
Myotonic dystrophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsatellite repeats. Characterized by symptoms in muscle, heart and central nervous system, among others, it is one of the most variable disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002c8569f10b446b2b55a88088f2be95
https://doi.org/10.1093/hmg/ddy432
https://doi.org/10.1093/hmg/ddy432
Autor:
Alicia J. Angelbello, Jonathan L. Chen, Suzanne G. Rzuczek, Walter N. Moss, Michael D. Cameron, Kendra K. McKee, Hailey Olafson, Eric T. Wang, Matthew D. Disney
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Development of small-molecule lead medicines that potently and specifically modulate RNA function is challenging. We designed a small molecule that cleaves r(CUG)exp, the RNA repeat expansion that causes myotonic dystrophy type 1. In cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b1f4cd36c4323ddfd10b8edaab0c41
https://pubmed.ncbi.nlm.nih.gov/30926669
https://pubmed.ncbi.nlm.nih.gov/30926669