Development of a Pediatric AML Patient Derived Xenograft Program

Autor: Alexandra McLean Stevens, Maci Terrell, Raushan Rashid, Jaime Omar Munoz, Alan K Gonzalez, Hailey H Oviedo, Tamilini Ilangovan, Michelle C Alozie, Michael Krueger, Kevin E. Fisher, Michele S. Redell

Publikováno v: Blood. 140:11807-11808

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b02203846916faf8dd64f93aeeb1eb5
https://doi.org/10.1182/blood-2022-170348

Combining Atovaquone with Intensive Conventional Chemotherapy for Pediatric Acute Myeloid Leukemia (AML) Is Feasible and Well Tolerated

Autor: Eunji Jo, Alicia E. Mangubat-Medina, Allison Weisnicht, Cara A Rabik, Susan G. Hilsenbeck, Todd M. Cooper, Hana Paek, Michelle C Alozie, Alexandra M. Stevens, Zachary T. Ball, Michele S. Redell, Minhua Li, Hailey H Oviedo, Alan K Gonzalez, Claire E. Bocchini, Haopei Wang, Maci Terrell, Raushan Rashid, Noah J Keogh, Eric S. Schafer

Publikováno v: Blood. 138:2312-2312

Background Relapse free survival of pediatric AML remains only 60%. Current standard myelosuppressive therapy has been maximized, so novel therapies with minimal toxicities are needed to improve outcomes. Previously, we found atovaquone (AQ), an FDA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0334ccefb5db8ce34b0c410aadef4e6
https://doi.org/10.1182/blood-2021-146057

Addressing a Pre-Clinical Pipeline Gap: Development of the Pediatric Acute Myeloid Leukemia Patient-Derived Xenograft Program at Texas Children's Hospital at Baylor College of Medicine.

Autor: Stevens AM; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Terrell M; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Rashid R; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Fisher KE; Department of Pathology & Immunology, Baylor College of Medicine, Genomic Medicine Division, Texas Children's Hospital, Houston, TX 77030, USA., Marcogliese AN; Department of Pathology & Immunology, Baylor College of Medicine, Laboratory Medicine Division, Texas Children's Hospital, Houston, TX 77030, USA., Gaikwad A; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Rao P; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Vrana C; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Krueger M; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Loken M; Hematologics, Seattle, WA 98121, USA., Menssen AJ; Hematologics, Seattle, WA 98121, USA., Cook JA; Hematologics, Seattle, WA 98121, USA., Keogh N; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Alozie M; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Oviedo H; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Gonzalez AK; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Ilangovan T; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Kim J; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Sandhu S; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA., Redell MS; Section of Hematology/Oncology, Department of Pediatrics, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, 1102 Bates St, Suite 750, Houston, TX 77030, USA.

Publikováno v: Biomedicines [Biomedicines] 2024 Feb 08; Vol. 12 (2). Date of Electronic Publication: 2024 Feb 08.