Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Haihua Chu"'
Autor:
S. Haihua Chu, Jonathan R. Chabon, Chloe N. Matovina, Janna C. Minehart, Bo-Ruei Chen, Jian Zhang, Vipul Kumar, Yijun Xiong, Elsa Callen, Putzer J. Hung, Zhaohui Feng, Richard P. Koche, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, Barry P. Sleckman, Scott A. Armstrong
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically b
Externí odkaz:
https://doaj.org/article/7b6e87225d7445a5aff36d4d395224c3
Autor:
Kimberly Stegmaier, Thomas Oellerich, John C. Byrd, Scott A. Armstrong, Federica Piccioni, James S. Blachly, Alison R. Walker, Arati V. Rao, Sebastian Mohr, Björn Häupl, Amy Goodale, Amanda Robichaud, Yana Pikman, S. Haihua Chu, Linda Ross, Elizabeth S. Frank, Gabriela Alexe, Jana M. Ellegast, Anjali Cremer
IC50, pYome results in MV4-11 and MOLM14, ORF-Screen Data in MV4-11 and MOLM14 and merged hits, SNV indels and copy number alteration of MV4-11 naive and resistant cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f446a75136175200fe6b9243820699d
https://doi.org/10.1158/2159-8290.22535731
https://doi.org/10.1158/2159-8290.22535731
Autor:
Scott A. Armstrong, Ross L. Levine, Anthony Letai, Hugh Y. Rienhoff, Scott W. Lowe, Timour Baslan, Johannes Zuber, Helen S. Tian, Madison Rex, Mitali Kini, Vidushi Durani, Nicole L. DelGaudio, Keith B. Cordner, Lihua Zou, Chun-Wei Chen, Chun-Hao Huang, Monica Cusan, Christopher A. Famulare, Filiz Sen, Martin S. Tallman, Eytan M. Stein, Jacob L. Glass, Richard P. Koche, Salma Parvin, Aaron D. Goldberg, S. Haihua Chu, Sheng F. Cai
shRNA screen hits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef0859770e92c8c152395bdc4620b8d
https://doi.org/10.1158/2159-8290.22536416.v1
https://doi.org/10.1158/2159-8290.22536416.v1
Autor:
Kimberly Stegmaier, Thomas Oellerich, John C. Byrd, Scott A. Armstrong, Federica Piccioni, James S. Blachly, Alison R. Walker, Arati V. Rao, Sebastian Mohr, Björn Häupl, Amy Goodale, Amanda Robichaud, Yana Pikman, S. Haihua Chu, Linda Ross, Elizabeth S. Frank, Gabriela Alexe, Jana M. Ellegast, Anjali Cremer
Spleen tyrosine kinase (SYK) is a nonmutated therapeutic target in acute myeloid leukemia (AML). Attempts to exploit SYK therapeutically in AML have shown promising results in combination with chemotherapy, likely reflecting induced mechanisms of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed0bced4c3c65f69e00b240c092325f0
https://doi.org/10.1158/2159-8290.c.6547933.v1
https://doi.org/10.1158/2159-8290.c.6547933.v1
Autor:
Scott A. Armstrong, Ross L. Levine, Anthony Letai, Hugh Y. Rienhoff, Scott W. Lowe, Timour Baslan, Johannes Zuber, Helen S. Tian, Madison Rex, Mitali Kini, Vidushi Durani, Nicole L. DelGaudio, Keith B. Cordner, Lihua Zou, Chun-Wei Chen, Chun-Hao Huang, Monica Cusan, Christopher A. Famulare, Filiz Sen, Martin S. Tallman, Eytan M. Stein, Jacob L. Glass, Richard P. Koche, Salma Parvin, Aaron D. Goldberg, S. Haihua Chu, Sheng F. Cai
Bliss synergy scores for in vitro venetoclax/IMG-7289 combination treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c67d11667513f9cb4d92e31f8616ee
https://doi.org/10.1158/2159-8290.22536413
https://doi.org/10.1158/2159-8290.22536413
Autor:
Scott A. Armstrong, Ross L. Levine, Anthony Letai, Hugh Y. Rienhoff, Scott W. Lowe, Timour Baslan, Johannes Zuber, Helen S. Tian, Madison Rex, Mitali Kini, Vidushi Durani, Nicole L. DelGaudio, Keith B. Cordner, Lihua Zou, Chun-Wei Chen, Chun-Hao Huang, Monica Cusan, Christopher A. Famulare, Filiz Sen, Martin S. Tallman, Eytan M. Stein, Jacob L. Glass, Richard P. Koche, Salma Parvin, Aaron D. Goldberg, S. Haihua Chu, Sheng F. Cai
The cell of origin of oncogenic transformation is a determinant of therapeutic sensitivity, but the mechanisms governing cell-of-origin–driven differences in therapeutic response have not been delineated. Leukemias initiating in hematopoietic stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c5021d4d800470cc3b706b15675c4c7
https://doi.org/10.1158/2159-8290.c.6548138.v1
https://doi.org/10.1158/2159-8290.c.6548138.v1
Autor:
Kimberly Stegmaier, Thomas Oellerich, John C. Byrd, Scott A. Armstrong, Federica Piccioni, James S. Blachly, Alison R. Walker, Arati V. Rao, Sebastian Mohr, Björn Häupl, Amy Goodale, Amanda Robichaud, Yana Pikman, S. Haihua Chu, Linda Ross, Elizabeth S. Frank, Gabriela Alexe, Jana M. Ellegast, Anjali Cremer
Computational analysis methods for RNAseq, WES, synergy analyse, Masspec information used for phosphoproteomic studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0031104ac2b4ad7ca6be0b8eff55fa7f
https://doi.org/10.1158/2159-8290.22535734.v1
https://doi.org/10.1158/2159-8290.22535734.v1
Autor:
Scott A. Armstrong, Ross L. Levine, Anthony Letai, Hugh Y. Rienhoff, Scott W. Lowe, Timour Baslan, Johannes Zuber, Helen S. Tian, Madison Rex, Mitali Kini, Vidushi Durani, Nicole L. DelGaudio, Keith B. Cordner, Lihua Zou, Chun-Wei Chen, Chun-Hao Huang, Monica Cusan, Christopher A. Famulare, Filiz Sen, Martin S. Tallman, Eytan M. Stein, Jacob L. Glass, Richard P. Koche, Salma Parvin, Aaron D. Goldberg, S. Haihua Chu, Sheng F. Cai
Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576108361133b2788982c2e7fea52dd6
https://doi.org/10.1158/2159-8290.22536419.v1
https://doi.org/10.1158/2159-8290.22536419.v1
Autor:
Kimberly Stegmaier, Thomas Oellerich, John C. Byrd, Scott A. Armstrong, Federica Piccioni, James S. Blachly, Alison R. Walker, Arati V. Rao, Sebastian Mohr, Björn Häupl, Amy Goodale, Amanda Robichaud, Yana Pikman, S. Haihua Chu, Linda Ross, Elizabeth S. Frank, Gabriela Alexe, Jana M. Ellegast, Anjali Cremer
Fig. S1: Characterization of effects of Entospletinib in AML in vitro and in vivo, Fig. S2: Genome-scale lentiviral ORFeome library screen identifies drivers of entospletinib resistance in AML.; Fig. S3: Viability analysis with increasing concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d05f501ea89488b1f31caab8d2352e
https://doi.org/10.1158/2159-8290.22535737
https://doi.org/10.1158/2159-8290.22535737
Autor:
Alexander Liquori, Ian Slaymaker, Daisy Lam, Giuseppe Ciaramella, Dieter Lam, Adam J. Hartigan, David A. Born, Jeremy Decker, Fei Ann Ran, S. Haihua Chu, Lo-I Cheng, Holly A. Rees, Jeffrey Marshall, Michael S. Packer, Bob Gantzer, Nicole M. Gaudelli, Jenny Olins, Luis A. Barrera, Yi Yu
Publikováno v:
The CRISPR Journal. 4:169-177
Base editors are fusions of a deaminase and CRISPR-Cas ribonucleoprotein that allow programmable installment of transition mutations without double-strand DNA break intermediates. The breadth of potential base editing targets is frequently limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2a2df0d40b5dcfb8fde74d08414d7f2
https://doi.org/10.1089/crispr.2020.0144
https://doi.org/10.1089/crispr.2020.0144