Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort

Autor: Qian Zhang, Paul Bastard, Haiguo Wu, Adrian Gervais, Seiamak Bahram, Sylvain Mayeur, Sharvari Gujja, Anne Thomas, Alexandre Lederle, Julie Helms, Christiane Moog, Xavier Mariette, Alain Viari, Tristan Stemmelen, Christine Carapito, Olivier Hermine, Richard Li, Daniel A. Lidar, Cécile Macquin, Jean Sibilia, Géraldine Laumond, Shweta Kailasan, Leslie Muller, Sabrina Bibi-Triki, Sylvie Schmidt, Aurélie Hirschler, Raony Guimaraes, Michael Simons, Anne Molitor, Francis Schneider, Damien Sanlaville, Thiên-Nga Chamaraux-Tran, Samira Fafi-Kremer, Pierre-Louis Tharaux, Thomas Chittenden, Angélique Pichot, A. Hanauer, Raphael Carapito, Mirjana Radosavljevic, Véronique Rolli, Bernard Goichot, Yvon Ruch, Olivier Collange, Ouria Tahar, Julien Pottecher, Khaldoun Kuteifan, Razieh Mohseninia, Perrine Spinnhirny, Alice Bernard, Bernard Drenou, Jean-Laurent Casanova, Elisa Pin, Jeffrey R. Gulcher, Paul-Michel Mertes, M. Javad Aman, Peter Nilsson, Jose Malagon-Lopez, François Danion, Yves Hansmann, Ferhat Meziani, Maleka Schenck, Nicodème Paul, Annabel Larnicol, Julia Frappier

Publikováno v: Science Translational Medicine
Science Translational Medicine, 2021, pp.1-59. ⟨10.1126/scitranslmed.abj7521⟩
Science Translational Medicine, American Association for the Advancement of Science, 2021, ⟨10.1126/scitranslmed.abj7521⟩

International audience; The etiopathogenesis of critical COVID-19 remains unknown. Indeed given major confounding factors (age and comorbidities), true drivers of this condition have remained elusive. Here, we employ an unprecedented multi-omics anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4c8db00ee20c68bec583014ad8e8e4
https://hal.science/hal-03436053

The pine Pschi4 promoter directs wound-induced transcription

Autor: Charles H. Michler, John M. Davis, Liborio LaRussa, Haiguo Wu

Publikováno v: Plant Science. 142:199-207

Mechanical wounding stimulates the accumulation of Pschi4 transcripts (encoding a putative extracellular chitinase) in pine trees. To gain insight into the transcriptional regulatory region(s) in this gymnosperm defense gene, the 5′-flanking region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da1a98e6e59c159568444e989621c354
https://doi.org/10.1016/s0168-9452(99)00009-6

Targeted high throughput sequencing of a cancer-related exome subset by specific sequence capture with a fully automated microarray platform

Autor: Peer F. Stähler, Stephan Bau, Nadine Schracke, Haiguo Wu, Yang Cheng, Markus Beier, Cord F. Stähler, Daniel Summerer

Sequence capture methods for targeted next generation sequencing promise to massively reduce cost of genomics projects compared to untargeted sequencing. However, evaluated capture methods specifically dedicated to biologically relevant genomic regio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3d315e0a93d8f28f9f1cbc69a9be44

Pathogen challenge, salicylic acid, and jasmonic acid regulate expression of chitinase gene homologs in pine

Autor: Jon Reed, Janice E. K. Cooke, John M. Davis, Charles H. Michler, Haiguo Wu, K. Scott Luce

Publikováno v: Molecular plant-microbe interactions : MPMI. 15(4)

To better understand the molecular regulation of defense responses in members of the genus Pinus, we tested the expression of various chitinase homologs in response to pathogen-associated signals. PSCHI4, a putative extracellular class II chitinase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d9dfc8d304f7bf45c15b9bd3bf3d58
https://pubmed.ncbi.nlm.nih.gov/12026177

Abstract 969: Amplifications, gene fusions, and therapeutic targets in triple negative and refractory ER+ and HER2+ breast cancers

Autor: Tara Holley, Zhongwu Lai, Kevin Webster, Wibhav Tembe, Michael T. Barrett, Deborah Morosini, Lihua Yu, Elizabeth Lenkiewicz, Lisa Evers, Haiguo Wu

Publikováno v: Cancer Research. 72:969-969

Breast cancer is known to be heterogeneous and choices of targeted therapy are still limited for refractory estrogen receptor positive (ER+), refractory HER2+, and triple negative (TNBC) breast cancer. In order to identify novel drug targets that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3946fd41d0e77687a30eb989fc79b656
https://doi.org/10.1158/1538-7445.am2012-969